Spontaneous and reflex movements may be found in patients with brain death (BD). The authors prospectively evaluated their frequency using a standardized protocol. Among 38 who fulfilled criteria for BD, the 15 (39%) spontaneous or movements. most common movement was finger jerks. Undulating toe flexion sign, triple response, Lazarus pronation-extension reflex, facial myokymia also were seen. These more than reported do not preclude diagnosis of BD.

Background: The primary aim of this study was to assess drug treatment adherence in patients with bipolar disorder and identify factors associated adherence. secondary analyze the impact suboptimal on clinical functional outcomes. Methods: A cross-sectional conducted a sample outpatients receiving an oral antipsychotic drug. Medication assessed combining 10-item Drug Attitude Inventory, Morisky Green Adherence Questionnaire, Compliance Rating Scale. Logistic regression used determine...

To evaluate the prevalence and impact of negative symptoms on healthcare resources utilization costs in patients with schizophrenia.A retrospective study was conducted using electronic medical records from health provider BSA (Badalona, Spain). All adult outpatients a diagnosis schizophrenia were followed for 12 months. Two groups defined by presence or absence based PANSS Negative Symptoms Factor (N1-N4, N6, G7 G16). Healthcare (direct cost) non-healthcare (work productivity losses)...

Background: Therapeutic inertia (TI) in multiple sclerosis (MS) is defined as the lack of treatment escalation when there evidence disease activity. Limited information available on physician-related factors influencing TI MS. The aim study was to evaluate whether physicians' risk preferences are associated with management MS by applying concepts from behavioral economics. Methods: A neurologists managing patients conducted Spain. Participants answered questions regarding 20 case-scenarios...

In multiple sclerosis (MS), half of affected people are unemployed within 10 years diagnosis. The aim this study was to assess the economic impact MS in adult subjects with relapsing-remitting (RRMS) and primary progressive (PPMS).A multicenter, non-interventional, cross-sectional conducted. Expanded Disability Status Scale (EDSS) 23-item Multiple Sclerosis Work Difficulties Questionnaire (MSWDQ-23) were used disability work performance, respectively. Only indirect costs considered using...

Background: Cognitive impairment has an impact upon the function and quality of life patients with multiple sclerosis (MS). High-serum neurofilament light-chain (sNfL) levels predict disease progression are also associated impaired cognitive performance. This study aimed to assess attitudes neurologists toward sNfL testing as regards making therapeutic decisions in clinically radiologically stable experiencing decline. Methods: A web-based observational was conducted among caring for MS. The...

Background: Metabolic syndrome (MetS) is one of the primary reasons for increased mortality in patients with schizophrenia. The mechanisms involved its pathogenesis are not well understood. Objective: To estimate prevalence MetS adult outpatients schizophrenia according to presence or absence negative symptoms. Materials and methods: A retrospective cohort study using electronic medical records was conducted. Positive Negative Syndrome Scale negative-symptom factor (N1–N4, N6, G7, G16) used...

The management of multiple sclerosis (MS) is rapidly changing by the introduction new and more effective disease-modifying agents. importance risk stratification was confirmed results on disease progression predicted different score systems. Despite these advances, we know very little about medical decisions under uncertainty in MS. goal this study to i) identify whether overconfidence, tolerance risk/uncertainty, herding influence decisions, ii) evaluate frequency therapeutic inertia...

The impact of comorbidity on multiple sclerosis (MS) is a new area interest. Limited data the risk factors metabolic syndrome (MetS) currently available. aim this study was to estimate presence comorbid conditions and MetS in sample adult patients with MS. A retrospective, cohort conducted using electronic medical records from 19 primary care centres Catalonia Asturias, Spain. number chronic diseases (diagnoses), Charlson Comorbidity Index individual Case-mix were used assess general...

Fatigue in multiple sclerosis is a key symptom associated with work-related problems and poor quality of life outcomes. The five-item Modified Impact Scale brief self-assessment tool for measuring the impact fatigue on cognitive, physical psychosocial function. A non-interventional, cross-sectional study was conducted to assess dimensionality item characteristics sclerosis. total 302 subjects were studied. Mokken analysis found strong one-dimensional scale (overall scalability index H =...

Multiple sclerosis (MS) is a chronic disease with high socioeconomic impact. The aim of this study was to assess healthcare resources utilization and costs in sample patients MS. A retrospective, cohort conducted using electronic medical records from 19 primary care centres Asturias Catalonia, Spain. Adult diagnosed MS were distributed into two groups according the Expanded Disability Status Scale (EDSS) score: 0–3.5 (no-moderate disability) 4–9.5 (severe disability). Healthcare (direct...

Objective To assess patients’ preferences for a range of disease-modifying therapy (DMT) attributes in multiple sclerosis (MS). Design A cross-sectional observational study. Setting The data reported were from 17 MS units throughout Spain. Participants Adult patients with relapsing-remitting MS. Main outcome conjoint analysis was applied to preferences. total 221 completed survey 10 hypothetical DMT profiles developed using an orthogonal design and rating 1 (most acceptable) (least...

Shared decision-making is a cornerstone of patient-centred care. The 9-item Decision-Making Questionnaire (SDM-Q-9) brief self-assessment tool for measuring patients' perceived level involvement in related to their own treatment and Information the psychometric properties SDM-Q-9 multiple sclerosis (MS) patients limited. objective this study was assess performance items composing its dimensional structure with relapsing-remitting MS. A non-interventional, cross-sectional adult MS conducted...

To assess the role of CSF chitinase 3-like-1 (CHI3L1), 3-like-2 (CHI3L2), and neurofilament light chain (NfL) in predicting course primary progressive MS (PPMS).We analyzed CHI3L1, CHI3L2, NfL levels 25 patients with PPMS disease duration ≤10 years no disease-modifying therapy for ≥6 months from prospective Understanding Primary Progressive Multiple Sclerosis cohort study. samples taken at diagnosis were using commercial ELISAs following manufacturer's instructions. Data on Expanded...

The simultaneous occurrence of intracerebral hemorrhages in different arterial territories is an uncommon clinical event. Its predisposing factors and pathophysiological mechanisms are not clearly defined.To analyze the frequency, risk factors, features, neuroimaging findings, outcome multiple (SIHs).We studied all patients with acute stroke admitted to our hospital from July 18, 1997, through December 1999. Multiple SIHs were defined as presence 2 or more affecting identical computed...

Assessment of pupillary diameter is useful for lesion location, a necessary step in diagnosing neurologic disorders.1,2 Recognition changes can serve as an early warning acute brain injury, and may, with prompt treatment, prevent further injury. However, not all are relevant, because size various physiologic or pharmacologic conditions.1 A few studies have evaluated the reliability nurses to assess pupils,3,4 but none physicians. Because, practice, physicians usually use their own...

Abstract Objective. Adherence to prescribed antipsychotic medication is a major factor in achieving optimal long-term clinical outcomes. The aim of this study was evaluate the impact telephone-based strategy provided by nurse on adherence treatment among patients with schizophrenia. Methods. A total 928 clinically stable outpatients schizophrenia were randomized receive monthly telephone call or routine care. Telephone calls performed at weeks 4, 8, and 12, consisting standardized interview...

Abstract Background The aim of the study was to determine most common pharmacological strategies used in management major depressive disorder (MDD) after an inadequate response first-line antidepressant treatment clinical practice. Methods Multicenter, non-interventional adult outpatients with a DSM-IV-TR diagnosis MDD and medication. Multiple logistic regression analyses were performed identify independent factors associated adoption specific second-line strategy. Results A total 273...

The primary aim of this study was to assess the range attitudes towards antipsychotic treatment at hospital discharge in patients with schizophrenia and bipolar disorder. secondary analyze relationship between patients' sociodemographic clinical parameters.A cross-sectional a sample admitted due acute exacerbation or manic episode conducted. Attitude pharmacological assessed 10-item Drug Inventory (DAI-10). Logistic regression used determine significant variables associated attitude...

There is growing interest in understanding and addressing factors that govern the decision-making process multiple sclerosis (MS) care. Therapeutic inertia (TI) failure to escalate therapy when goals are unmet. Limited data available on prevalence of TI affecting therapeutic decisions management patients with MS worldwide.To compare across 4 countries (Canada, Argentina, Chile, Spain) identify contributing TI.Prospective cohort study conducted between July 10, 2017, May 4, 2018. Participants...