A5015882829- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyomavirus and related diseases
- Metabolism and Genetic Disorders
- Retinal Development and Disorders
- Neurogenesis and neuroplasticity mechanisms
- Pharmacological Effects and Toxicity Studies
- Liver Disease and Transplantation
- Studies on Chitinases and Chitosanases
- RNA Research and Splicing
- Neurological Disorders and Treatments
- Diet and metabolism studies
- RNA regulation and disease
- Systemic Sclerosis and Related Diseases
- Dementia and Cognitive Impairment Research
- Birth, Development, and Health
- Monoclonal and Polyclonal Antibodies Research
- Extracellular vesicles in disease
- Advanced Electron Microscopy Techniques and Applications
- Prion Diseases and Protein Misfolding
- Rheumatoid Arthritis Research and Therapies
- Alzheimer's disease research and treatments
Hospital Universitari i Politècnic La Fe
2018-2025
Instituto de Investigación Sanitaria La Fe
2017-2023
Hospital Universitario Doctor Peset
2021
Hospital Clínico Universitario de Valencia
2020
Hospital Universitario Puerta de Hierro Majadahonda
2020
Roche (Spain)
2020
Universitat de València
2016
Inflammation contributes to cognitive impairment in patients with hepatic encephalopathy (HE). However, the process by which peripheral inflammation results remains unclear. In animal models, neuroinflammation and altered neurotransmission mediate impairment. Taking into account these data, we hypothesized that rats HE: 1) is a main contributor neuroinflammation; 2) hippocampus impairs spatial learning altering AMPA and/or NMDA receptors membrane expression; 3) reducing infliximab...
Background: Neurofilament light chain protein (NFL) and chitinase3-like1 (CHI3L1) have gained importance recently as prognostic biomarkers in multiple sclerosis (MS). Objectives: We aimed to investigate NFL CHI3L1 cerebrospinal fluid (CSF) profiles the informative potential of individual combined measures. Methods: CSF levels were measured a cross-sectional cohort 157 MS patients (99 relapsing-remitting (RRMS), 35 secondary progressive (SPMS), 23 primary (PPMS)). Clinical relapse and/or...
Abstract Background Patients with liver cirrhosis may develop hepatic encephalopathy. Rats chronic hyperammonemia exhibit neurological alterations mediated by peripheral inflammation and neuroinflammation. Motor incoordination is due to increased TNF-a levels activation of its receptor TNFR1 in the cerebellum. The aims were assess (a) whether responsible for induction hyperammonemic rats, (b) cell type(s) which increased, (c) this increase associated nuclear NF-κB activation, (d) time course...
<h3>Objective</h3> Neurofilament light protein (NfL) and chitinase 3–like 1 (CHI3L1) are biomarkers for acute neuroaxonal damage local inflammation, respectively. Thus, we set out to evaluate how these were associated with clinical features of demyelinating diseases in parallel the expression brain autopsies from patients similar disease stages, assuming their comparability. <h3>Methods</h3> NfL CHI3L1 CSF serum assessed retrospectively a cross-sectional cohort controls (n = 17) diagnosed MS...
Abstract Background The validation of a combination plasma biomarkers and demographic variables is required to establish reliable cut‐offs for Alzheimer's disease diagnosis (AD). Methods Plasma (Aβ42/Aβ40, p‐Tau181, t‐Tau, NfL, GFAP), ApoE genotype, were obtained from retrospective clinical cohort cognitive disorders ( n = 478). These patients diagnosed as AD 254) or non‐AD 224) according cerebrospinal fluid (CSF) Aβ42/Aβ40 levels. An analysis using Ridge logistic regression model was...
To assess the role of CSF chitinase 3-like-1 (CHI3L1), 3-like-2 (CHI3L2), and neurofilament light chain (NfL) in predicting course primary progressive MS (PPMS).We analyzed CHI3L1, CHI3L2, NfL levels 25 patients with PPMS disease duration ≤10 years no disease-modifying therapy for ≥6 months from prospective Understanding Primary Progressive Multiple Sclerosis cohort study. samples taken at diagnosis were using commercial ELISAs following manufacturer's instructions. Data on Expanded...
Cerebrospinal kappa free light chain (KFLC)-index is a marker of intrathecal immunoglobulin synthesis that aids in the diagnosis multiple sclerosis (MS). However, little evidence exists on its prognostic role. Our aim to analyze relationship between KFLC-index and other MS biomarkers explore This monocentric observational study cohort 52 people with relapsing (pwRMS) performed prospectively acquired clinical data retrospective evaluation biomarkers. We measured KFLC-index, synthesis,...
The clinical diagnosis of patients with autoantibodies directed to conformational myelin oligodendrocyte glycoprotein, (MOG)-IgG, can be challenging because atypical presentation. MOG-IgG seropositivity has been reported in several demyelinating diseases, including relapsing opticospinal syndromes (in the neuromyelitis optica spectrum disorders [NMOSD] and less frequently, multiple sclerosis [MS]), but it rarely associated progressive course disease. To contribute characterization...
Alzheimer's disease (AD) is the most prevalent dementia, but it shows similar initial symptoms to other neurocognitive diseases (Lewy body (LBD) and frontotemporal dementia (FTD)). Thus, identification of reliable AD plasma biomarkers required. The aim this work evaluate use a few develop an early specific screening method. Plasma p-Tau181, neurofilament light (NfL), glial fibrillary acid protein (GFAP) were determined by Single Molecule Assay (SIMOA® Quanterix, Billerica, MA, USA) in...
In situ RT-PCR detects and amplifies mRNA while obtaining spatial information of gene expression. When the intended use is an ultrastructural analysis morphology, procedure may be technically challenging quality tissue dramatically altered. We describe a low-damaging protocol in combined to conventional electron microscopy that preserves fine morphology. This allowed us defining novel population tanycytes third ventricle adult mice.
Background : The assessment of serum neurofilament light chain (sNfL) is increasingly significant in the field neurology. In multiple sclerosis (MS), it proves valuable as a marker for monitoring disease activity and treatment response. Objective To compare Simoa Lumipulse platforms measuring sNfL to establish age‐specific reference ranges within substantial cohort individuals diagnosed with MS. Methods: Two hundred sixty‐one measurements from 229 MS patients were analyzed Lumipulse....
Objective To determine baseline cerebrospinal fluid and magnetic resonance imaging (MRI) variables at the onset of a clinically isolated syndrome (CIS) suggestive multiple sclerosis (MS) that predict evolution to secondary progressive MS (SPMS). Methods 276 CIS patients with minimum follow-up 10 years were studied. Baseline presence oligoclonal IgG IgM bands (OCGB OCMB respectively); number brain T2 lesions (B-T2L), gadolinium enhancement (brain-GEL), cervical spinal cord (cSC-T2L);...