A5005104382- Multiple Sclerosis Research Studies
- Polyomavirus and related diseases
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Neurogenesis and neuroplasticity mechanisms
- Studies on Chitinases and Chitosanases
- Skin and Cellular Biology Research
- Ion channel regulation and function
- Amino Acid Enzymes and Metabolism
- RNA regulation and disease
- Pediatric Hepatobiliary Diseases and Treatments
- Complement system in diseases
- Liver Disease and Transplantation
- Extracellular vesicles in disease
- Gallbladder and Bile Duct Disorders
- Ion Transport and Channel Regulation
- Monoclonal and Polyclonal Antibodies Research
- Peripheral Neuropathies and Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- SARS-CoV-2 and COVID-19 Research
- Systemic Sclerosis and Related Diseases
- Amyotrophic Lateral Sclerosis Research
- Prion Diseases and Protein Misfolding
Universitat de València
2023
Instituto de Investigación Sanitaria La Fe
2021-2023
Hospital Universitari i Politècnic La Fe
2022
Hospital Universitario Doctor Peset
2021
Background: Neurofilament light chain protein (NFL) and chitinase3-like1 (CHI3L1) have gained importance recently as prognostic biomarkers in multiple sclerosis (MS). Objectives: We aimed to investigate NFL CHI3L1 cerebrospinal fluid (CSF) profiles the informative potential of individual combined measures. Methods: CSF levels were measured a cross-sectional cohort 157 MS patients (99 relapsing-remitting (RRMS), 35 secondary progressive (SPMS), 23 primary (PPMS)). Clinical relapse and/or...
<h3>Objective</h3> Neurofilament light protein (NfL) and chitinase 3–like 1 (CHI3L1) are biomarkers for acute neuroaxonal damage local inflammation, respectively. Thus, we set out to evaluate how these were associated with clinical features of demyelinating diseases in parallel the expression brain autopsies from patients similar disease stages, assuming their comparability. <h3>Methods</h3> NfL CHI3L1 CSF serum assessed retrospectively a cross-sectional cohort controls (n = 17) diagnosed MS...
mRNA coronavirus disease 2019 (COVID-19) vaccination has been widely used to arrest the spread of severe acute respiratory syndrome 2 (SARS-CoV-2) pandemic. Rarely, autoimmune events such as relapses in patients with multiple sclerosis (MS) have reported after vaccination. However, possible effects a patient already experiencing symptoms relapse represent an unusual scenario that not described.This is retrospective case series four from three major tertiary referral centers received COVID-19...
Cerebrospinal kappa free light chain (KFLC)-index is a marker of intrathecal immunoglobulin synthesis that aids in the diagnosis multiple sclerosis (MS). However, little evidence exists on its prognostic role. Our aim to analyze relationship between KFLC-index and other MS biomarkers explore This monocentric observational study cohort 52 people with relapsing (pwRMS) performed prospectively acquired clinical data retrospective evaluation biomarkers. We measured KFLC-index, synthesis,...
Serum neurofilament light chain (sNfL) is a biomarker of neuroaxonal destruction that correlates with acute inflammation (AI) in multiple sclerosis (MS). However, the treatment era, progression without AI main driver long-term disability. sNfL may provide added value detecting ongoing axonal damage and neurological worsening patients AI. We conducted prospective three-year study on first MS relapse to evaluate basal cut-off predicting early increased disability unrelated relapses.
Background : The assessment of serum neurofilament light chain (sNfL) is increasingly significant in the field neurology. In multiple sclerosis (MS), it proves valuable as a marker for monitoring disease activity and treatment response. Objective To compare Simoa Lumipulse platforms measuring sNfL to establish age‐specific reference ranges within substantial cohort individuals diagnosed with MS. Methods: Two hundred sixty‐one measurements from 229 MS patients were analyzed Lumipulse....