A5042949861- Skin Protection and Aging
- Alzheimer's disease research and treatments
- melanin and skin pigmentation
- Dementia and Cognitive Impairment Research
- Dyeing and Modifying Textile Fibers
- Olfactory and Sensory Function Studies
- Biochemical Analysis and Sensing Techniques
- Metabolomics and Mass Spectrometry Studies
- Dye analysis and toxicity
- S100 Proteins and Annexins
- Dialysis and Renal Disease Management
- Cholesterol and Lipid Metabolism
- Indoor Air Quality and Microbial Exposure
- Aging, Health, and Disability
- Renal cell carcinoma treatment
- Biological Research and Disease Studies
- Intensive Care Unit Cognitive Disorders
- Carcinogens and Genotoxicity Assessment
- Circular RNAs in diseases
- Contact Dermatitis and Allergies
- Pesticide Residue Analysis and Safety
- Stress Responses and Cortisol
- Heme Oxygenase-1 and Carbon Monoxide
- Analytical chemistry methods development
- Insect and Pesticide Research
Instituto de Investigación Sanitaria La Fe
2022-2025
Universitat de València
2005-2024
Universitat Politècnica de València
2012
The microRNAs (miRNAs) are potential biomarkers for complex pathologies due to their involvement in the regulation of several pathways. Alzheimer Disease (AD) requires new minimally invasive samples that allow an early diagnosis. aim this work is study miRNAS as AD and role pathology development. In study, participants (n = 46) were classified into mild cognitive impairment (MCI-AD, n 19), preclinical 8) healthy elderly controls according CSF levels (amyloid β42, total tau, phosphorylated...
Alzheimer’s disease (AD) is the primary type of dementia, followed by frontotemporal lobar degeneration (FTLD). They share some clinical characteristics, mainly at early stages. So, identification early, specific, and minimally invasive biomarkers required. In this study, plasma (Amyloid β42, p-Tau181, t-Tau, neurofilament light (NfL), TAR DNA-binding protein 43 (TDP-43)) were determined single molecule array technology (SIMOA®) in control subjects (n = 22), mild cognitive impairment due to...
Abstract Lipids are the major component of brain with important structural and functional properties. Lipid disruption could play a relevant role in Alzheimer’s disease (AD). Some lipidomic studies showed significant differences compared to controls, but few have focused on different areas related AD. Furthermore, AD is more prevalent females, there lack focusing this sex. This work aims perform study selected (cerebellum, amygdala, hippocampus, entire cortex) from wild-type (WT, n = 10)...
Chronic kidney disease (CKD) affects approximately 12% of the global population posing a significant health threat. Inflammation plays crucial role in uremic phenotype CKD contributing to elevated cardiovascular and overall mortality affected individuals. This study aimed explore novel metabolic pathways non-dialysis dependent stage 5 patients using semitargeted metabolomics. In prospective observational design involving 50 patients, blood samples collected before initial hemodialysis...
Abstract Background The validation of a combination plasma biomarkers and demographic variables is required to establish reliable cut‐offs for Alzheimer's disease diagnosis (AD). Methods Plasma (Aβ42/Aβ40, p‐Tau181, t‐Tau, NfL, GFAP), ApoE genotype, were obtained from retrospective clinical cohort cognitive disorders ( n = 478). These patients diagnosed as AD 254) or non‐AD 224) according cerebrospinal fluid (CSF) Aβ42/Aβ40 levels. An analysis using Ridge logistic regression model was...
Ascorbic acid (AA), also known as vitamin C, is a very popular skin-whitening agent used in cosmetics. However, the use of AA (and its sodium or magnesium salts) cosmetic products limited owing to labile oxidative properties. In order avoid early degradation, different derivatives have been designed, such ascorbyl phosphate (APH; and palmitate (AP), more recently glucoside (AG). Bearing mind that all these chemicals must be determined control efficacy products, this paper focuses on...
Alzheimer disease (AD) is a heterogeneous and complex in which different pathophysiological mechanisms are involved. This heterogenicity can be reflected atrophy patterns or clinical manifestations. Regarding biochemical pathways involved early AD, lipid metabolism plays an important role; therefore, levels have been evaluated as potential AD diagnosis biomarkers, their could related to Therefore, the aim of this work study profiles from patients evaluate significance. For purpose,...
3.9 million individuals rely on kidney replacement therapy worldwide. They experience height-ened susceptibility to cardiovascular diseases and mortality, alongside an increased risk of in-fections malignancies, with inflammation being key explaining this intensified risk. This study utilized semi-targeted metabolomics explore novel metabolic pathways related in-flammation in populations. We collected pre post-session blood samples patients who had already undergone one year chronic...
Alzheimer's disease (AD) is the most prevalent dementia, showing higher incidence in women. Besides, lipids play an essential role brain, and they could be dysregulated neurodegeneration. Specifically, impaired plasma lipid levels predict early AD diagnosis. This work aims to identify main altered female mouse model evaluate their relationship with brain lipidome. Also, possible involvement of estrous cycle metabolism has been evaluated.
Alzheimer's disease (AD) is the most prevalent dementia, but it shows similar initial symptoms to other neurocognitive diseases (Lewy body (LBD) and frontotemporal dementia (FTD)). Thus, identification of reliable AD plasma biomarkers required. The aim this work evaluate use a few develop an early specific screening method. Plasma p-Tau181, neurofilament light (NfL), glial fibrillary acid protein (GFAP) were determined by Single Molecule Assay (SIMOA® Quanterix, Billerica, MA, USA) in...
Alzheimer disease (AD) is the main cause of dementia, and its complexity not yet completely understood. Proteomic profiles can provide useful information to explore pathways involved heterogeneity among AD patients. A proteomic analysis was performed in cerebrospinal fluid (CSF) samples from mild cognitive impairment due (MCI-AD) control individuals; both groups were classified by amyloid β42/amyloid β40 levels CSF (data available BioStudies database (S-BSST1456)). The based on PLS...
Intoduction: The heterogenicity in Alzheimer's Disease (AD) progression hinders individual prognosis. present work is an observational 2-year longitudinal study patients with mild cognitive impairment due to AD (n= 52, positive CSF biomarkers). aim of this predict which are at risk fast progression. For this, 3 neuropsychological tests based on different domains (clinical dementia, cognition, delayed memory) and the sum them were used. Method: performed diagnosis time (T1) two years after...