A5041260468- Endometriosis Research and Treatment
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cardiovascular Effects of Exercise
- Uterine Myomas and Treatments
- Endometrial and Cervical Cancer Treatments
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Sports injuries and prevention
- Cancer-related molecular mechanisms research
- Reproductive System and Pregnancy
- Ion channel regulation and function
- Cardiovascular Disease and Adiposity
- Liver Disease Diagnosis and Treatment
- Ion Transport and Channel Regulation
- Glycogen Storage Diseases and Myoclonus
- Osteoarthritis Treatment and Mechanisms
- Cardiac Arrhythmias and Treatments
- Antimicrobial Peptides and Activities
- Saffron Plant Research Studies
- Phytochemical and Pharmacological Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Angiogenesis and VEGF in Cancer
- Dye analysis and toxicity
- Prenatal Substance Exposure Effects
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021-2024
Instituto de Investigación Sanitaria La Fe
2013-2024
Instituto de Salud Carlos III
2024
Centre for Biomedical Network Research on Rare Diseases
2021-2023
Leitat Technological Center
2006-2022
Hospital Universitari i Politècnic La Fe
2011-2020
Construcciones y Auxiliar de Ferrocarriles (Spain)
2020
British Heart Foundation
2020
King's College London
2020
Instituto Politécnico Nacional
2011-2015
Could an aberrant microRNA (miRNA) expression profile be responsible for the changes in angiogenic and fibrinolytic states observed endometriotic lesions?This study revealed characteristic miRNA profiles associated with endometriosis endometrial tissue lesions from same patient their correlation most important factors. WHAT IS ALREADY KNOWN?: An role dysregulated pathogenesis of is well documented. However, to best our knowledge, there are no reports relationship between factors miRNAs when...
BACKGROUNDEndometriosis is a common, multifactorial disease in which angiogenesis may be involved the growth of endometrium outside uterus. microRNAs (miRNAs) are 21–22 nucleotide non-coding RNAs that regulate gene expression and play fundamental roles biological processes. The objective this study was to analyze several miRNAs related angiogenic factors, vascular endothelial factor-A (VEGF-A) thrombospondin-1 (TSP-1), endometriotic lesions (ovarian endometrioma, peritoneal lesion...
The microRNAs (miRNAs) are potential biomarkers for complex pathologies due to their involvement in the regulation of several pathways. Alzheimer Disease (AD) requires new minimally invasive samples that allow an early diagnosis. aim this work is study miRNAS as AD and role pathology development. In study, participants (n = 46) were classified into mild cognitive impairment (MCI-AD, n 19), preclinical 8) healthy elderly controls according CSF levels (amyloid β42, total tau, phosphorylated...
Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer? A dysregulated expression miRNAs an increase levels were observed cancer comparison with control. The different could modulate angiogenic antiangiogenic factors, which may play important pathogenesis cancer. Dysregulated miRNA has been previously evaluated adenocarcinoma. To best our knowledge, there are...
STUDY QUESTIONCould peritoneal fluid (PF) from patients with endometriosis alter the microRNA (miRNA) expression profile in endometrial and endometriotic cells patients?
Non-alcoholic fatty liver disease (NAFLD) appears to be a new risk factor for the development of coronary artery (CAD). Members class non-coding RNAs, termed microRNAs (miRNAs), have been identified as post-transcriptional regulators cholesterol homoeostasis and can contribute NAFLD. The aims this study were (i) assess relationship between NAFLD sudden cardiac death (SCD) from severe CAD in forensic autopsies (ii) quantify several hepatic miRNAs previously associated with lipid metabolism...
Arrhythmogenic cardiomyopathy (ACM) is a primary myocardial disease that typically manifests with cardiac arrhythmias, progressive heart failure, and sudden death (SCD). ACM mainly caused by mutations in genes encoding desmosome proteins. Desmosomes are cell-cell adhesion structures hubs for mechanosensing mechanotransduction. The objective was to identify the dysregulated molecular biological pathways human absence of overt failure.Transcriptomes right ventricular endomyocardial biopsy...
Andersen-Tawil syndrome type 1 is a rare heritable disease caused by mutations in the gene coding strong inwardly rectifying K
Genetic disease has recently emerged as a cause of cardiac conduction disorders (CCDs), but the diagnostic yield genetic testing and contribution different genes to CCD is still unsettled. This study sought determine in young adults with unknown etiology requiring pacemaker implantation. We also studied prevalence rare protein-altering variants across individual functional gene groups. performed whole exome sequencing 150 patients who had permanent implanted at age ≤60 years 14 Spanish...
BACKGROUNDEndometriosis, defined as the presence of endometrium outside uterus, is one most frequent benign gynaecological diseases. It has been suggested that both endometrial and peritoneal factors, related to angiogenesis proteolysis, can be implicated in this disease. The aim study was evaluate influence fluid on expression angiogenic proteolytic factors cultures cells from women with without endometriosis.
Endometriosis, defined as the presence of endometrium outside uterus, is one most frequent gynecological diseases. It has been suggested that modifications both endometrial and peritoneal factors could be implicated in this disease. Endometriosis a multifactorial disease which angiogenesis proteolysis are dysregulated. MicroRNAs (miRNAs) small non-coding RNAs regulate protein expression may main regulators angiogenesis. Our hypothesis fluid from women with endometriosis modify several miRNAs...
There is evidence for the effects of platelet inhibition on innate immune activation. Circulating microRNAs (miRNAs) have been implicated as markers and leukocyte In present study, we assessed P2Y12 inhibitors miRNAs during endotoxemia. Healthy volunteers were randomly assigned to receive oral ticagrelor (n = 10), clopidogrel 8) or no drug one week, followed by an intravenous bolus 2 ng/kg endotoxin. Serum was collected at baseline, after week antiplatelet treatment 6 24 h endotoxin...
Abstract The purpose of this study was to investigate several inflammatory mediators and cartilage degradation molecules as possible biomarkers joint lesion in the anterior cruciate ligament transection (ACLT) model osteoarthritis rats. We also assessed whether treatment with anti‐inflammatory agent tin protoporphyrin IX (SnPP) reduces progression disease. Our results indicate that serum levels interleukin (IL)‐6 PGE 2 are significantly increased ACLT rats 10 weeks after surgery, whereas...
Saffron, as a food colorant, has been displaced by low-cost synthetic dyes. These have unhealthy properties; thus, their replacement with natural colorants is an emerging trend. Obesity worldwide health problem due to its associated comorbidities. Crocetin esters (crocins) are responsible for the red saffron color. (CCT) exhibits healthful properties. We aimed broaden existing knowledge on properties of CCT isolated from saffron, facilitate consideration healthy colorant in future. evaluated...