A5040399381- Nitric Oxide and Endothelin Effects
- Saffron Plant Research Studies
- Renin-Angiotensin System Studies
- Phytochemical and Pharmacological Studies
- Cardiovascular Disease and Adiposity
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Disease Prevention
- Eicosanoids and Hypertension Pharmacology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroscience of respiration and sleep
- Apelin-related biomedical research
- Adipose Tissue and Metabolism
- Phytochemicals and Antioxidant Activities
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Metabolism, Diabetes, and Cancer
- Hedgehog Signaling Pathway Studies
- Problem Solving Skills Development
- Cancer-related Molecular Pathways
- Flavonoids in Medical Research
- Biological Activity of Diterpenoids and Biflavonoids
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Medical Education and Admissions
University of Castilla-La Mancha
2013-2024
Duran i Reynals Hospital
2016
Institut Català d'Oncologia
2016
Consejería de Educación de la Junta de Castilla y León
2005
Ministerio de Ciencia y Tecnología
2005
Universitat de València
2000-2004
Crocus sativus L. extracts (saffron) are rich in carotenoids. Preclinical studies have shown that dietary intake of carotenoids has antitumor effects suggesting their potential preventive and/or therapeutic roles. We recently reported saffron (SE) and crocin (CR) exhibit anticancer activity by promoting cell cycle arrest prostate cancer (PCa) cells. It also been demonstrated crocetin esters produced after SE gastrointestinal digestion CR hydrolysis. The aim the present report was to...
Metabolic syndrome is a cluster of metabolic and cardiovascular symptoms: insulin resistance (IR), obesity, dyslipemia. Hypertension vascular disorders are central to this syndrome. After brief historical review, we discuss the role sympathetic tone. Subsequently, examine link between endothelial dysfunction IR. NO involved in insulin-elicited capillary vasodilatation. The insulin-signaling pathways causing release different classical. There vasodilatory pathway with activation synthase...
Over recent years, many authors discussed the effects of different natural compounds on glioblastoma (GBM). Due to its capacity impair survival and progression cancer types, saffron extract (SE), named crocetin (CCT), is particularly noteworthy. In this work, we elucidated antitumor properties in glioma vivo vitro models for first time. The results showed that four tumor cell lines observed study (U251, U87, U138, U373), which were treated with increasing doses crocetin, antiproliferative...
<b><i>Background:</i></b> Hypertension is associated with endothelial dysfunction characterized by decreased vasorelaxation. Crocetin, a bioactive compound of saffron, exhibits favorable cardiovascular properties. We analyze the vasomodulatory effects crocetin in hypertension. <b><i>Methods:</i></b> Myographical experiments were performed to compare relaxation induced acetylcholine (ACH) on aortic rings from normotensive (Wistar) and...
Background: Endothelial dysfunction, characterized by an enhancement in vasoconstriction, is clearly associated with hypertension. Saffron (Crocus sativus L.) bioactive compounds have been recognized to hypotensive properties. Recently, we reported that crocetin exhibits potent vasodilator effects on isolated aortic rings from hypertensive rats. In this work, aimed analyze the anticontractile ability of or esters pool (crocins) saffron. Thus, studied saffron carotenoids endothelium-dependent...
The obese spontaneously hypertensive rat (SHROB) is a model of metabolic syndrome in which, to our knowledge, vascular function has never been studied. actions insulin sensitizers (glitazones) on have not analyzed either. Our purpose was characterize microvascular and macrovascular responses the SHROB study effects glitazones these responses. reactivity mesenteric resistance arteries (MRAs) aorta from SHROBs control rats cumulative concentrations phenylephrine, ACh, sodium nitroprusside...
Objective To assess the nitric oxide (NO) system in cardiovascular and renal systems of old Wistar–Kyoto (WKY) rats spontaneously hypertensive (SHR) compared with young same strains. Design methods The NO pathway was assessed: (i) analytical studies measuring concentration nitrate plasma activity synthases left ventricle, cortex medulla; (ii) functional studies, which we measured blood pressure effects blockade intravenous NG-nitro-L-arginine methyl ester (L-NAME, 0.1 mg/kg) anaesthetized...
Currently, olive leaves are considered waste, although their high phenolic content makes them a source of antioxidants that could be used directly. The aim this work was to study the behavior compounds contained in leaf from mill production chain during gastrointestinal digestion.
Saffron, as a food colorant, has been displaced by low-cost synthetic dyes. These have unhealthy properties; thus, their replacement with natural colorants is an emerging trend. Obesity worldwide health problem due to its associated comorbidities. Crocetin esters (crocins) are responsible for the red saffron color. (CCT) exhibits healthful properties. We aimed broaden existing knowledge on properties of CCT isolated from saffron, facilitate consideration healthy colorant in future. evaluated...