A5024634587- Nitric Oxide and Endothelin Effects
- Eicosanoids and Hypertension Pharmacology
- Renin-Angiotensin System Studies
- Biosimilars and Bioanalytical Methods
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Economics and Policy
- Heart Rate Variability and Autonomic Control
- Saffron Plant Research Studies
- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Neuroscience of respiration and sleep
- Antibiotic Use and Resistance
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Phytochemical and Pharmacological Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacovigilance and Adverse Drug Reactions
- Pharmaceutical Practices and Patient Outcomes
- Diabetes Management and Research
- Systemic Lupus Erythematosus Research
- Pharmaceutical studies and practices
- Neuroscience and Neuropharmacology Research
- Computational Drug Discovery Methods
University of Castilla-La Mancha
2013-2024
Ministero della Salute
2023
Universidad Bíblica Latinoamericana
2023
University of Milan
2023
Ministry of Health of the Russian Federation
2023
ASL Roma
2023
Universidad de Costa Rica
2023
Regione Lombardia
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2016-2023
Regional Health
2022
We have investigated whether the myocardium and isolated cardiac myocytes can express a Ca 2+ ‐independent NO synthase after treatment with endotoxin or cytokines. Nitric oxide synthesis was measured in cytosols from left ventricular wall rats treated endotoxin, freshly adult vitro Cytosols ventricle of saline‐treated control animals showed only ‐dependent synthesis. After expression an inducible, observed. The activity this enzyme maximal at 6 h returned towards levels by 18 h; no...
Background Biosimilar drugs represent a valuable opportunity for healthcare systems worldwide as they offer substantial cost savings. This retrospective observational study aimed to assess the current prescribing trend in order raise awareness among physicians more appropriate prescribing.
Summary: The role of nitric oxide (NO) in the changes blood pressure and plasma levels nitrate nitrite (NOx) alanine aminotransferase (ALT) were determined over a 5-h period anesthesized rats after intravenous administration S. typhosa endotoxin (LPS, 4 mg/kg). Rats treated with LPS showed sustained fall accompanied by an increase NOx ALT. Forty percent these died during experiment. There was no change dexamethasone (1 mg/kg) 1 h before 2 ALT significantly inhibited. None this group died....
We analyzed the activity of nitric oxide synthase in rat heart to study whether this is affected by high blood pressure. Hearts from young (3 4 weeks old) and adult (15 25 Wistar-Kyoto (WKY) rats spontaneously hypertensive (SHR) were excised frozen liquid nitrogen. The activities Ca(2+)-dependent (cNOS) Ca(2+)-independent (iNOS) determined homogenized tissues measuring conversion [14C]-L-arginine [14C]-L-citrulline presence or absence either EGTA (1 mmol/L) plus NG-nitro-L-arginine methyl...
Metabolic syndrome is a cluster of metabolic and cardiovascular symptoms: insulin resistance (IR), obesity, dyslipemia. Hypertension vascular disorders are central to this syndrome. After brief historical review, we discuss the role sympathetic tone. Subsequently, examine link between endothelial dysfunction IR. NO involved in insulin-elicited capillary vasodilatation. The insulin-signaling pathways causing release different classical. There vasodilatory pathway with activation synthase...
Abstract The objective of this study was to examine the effects long-term antihypertensive therapy on blood pressure and vascular responses resistance arteries during prolonged inhibition nitric oxide synthesis. Four groups 6-week-old Wistar-Kyoto rats were treated with either placebo as controls or N ω -nitro- l -arginine methyl ester (L-NAME) alone in combination verapamil trandolapril. Drugs given orally for 6 weeks short-term vitro vessels obtained from untreated rats....
Background/Objectives: Although extemporaneous formulations of anticancer drug products for personalized therapy are produced according to Good Hospital Pharmacy Manufacturing Practice, the lack knowledge about stability under clinical conditions limits second-time use these highly costly medications in practice. Therefore, residual compounded drugs considered waste and a cost item that negatively affects healthcare system. In context ever-increasing interest health system applying practices...
Objectives To examine the role of nitric oxide in cardiovascular system spontaneous hypertension. In particular, we wanted to know whether production spontaneously hypertensive rat is different from that normotensive Wistar–Kyoto and biologically effective this system. Design We studied various aspects L-arginine–nitric pathway rats rats. Methods address first objective analysed expression endothelial synthase heart by Western blotting activity constitutive resistance microvessels obtained...
The increased prescribing and dispensing of new drugs for type 2 diabetes mellitus due to less stringent prescription regulations has led both bringing therapies closer the patient, as required by post-Covid-19 European policies, an unpredictable increase in health care spending. In particular, Italy, with introduction National Plan Reconstruction Resilience, attempt been made give more prescriptive freedom General Practitioner (GP). Through notes, patients can directly go primary physician...
Objective To elucidate the role of L‐arginine: nitric oxide pathway in pregnancy and pre‐eclampsia. Participants Pregnant women (nulliparous, age < 25 years). Normotensive ( n = 22 ) was defined when blood pressure remained at levels 120/80 mmHg there no proteinuria. Women with pre‐eclampsia had measurements > 140/90 proteinuria 300 mg/l. Nonpregnant normotensive were studied as controls. Study Design Blood samples taken for ionised calcium, atrial natriuretic factor, cyclic guanosine...
<b><i>Background:</i></b> Hypertension is associated with endothelial dysfunction characterized by decreased vasorelaxation. Crocetin, a bioactive compound of saffron, exhibits favorable cardiovascular properties. We analyze the vasomodulatory effects crocetin in hypertension. <b><i>Methods:</i></b> Myographical experiments were performed to compare relaxation induced acetylcholine (ACH) on aortic rings from normotensive (Wistar) and...
Atrial fibrillation is a condition which frequently occurs in the elderly causing contraction of portion heart. It can be either perceived as an uncomfortable sensation or it may completely silent, but when untreated, impact negatively on human health. In recent years, traditional therapy based warfarin and acenocoumarol has been increasingly replaced by new oral anticoagulants (NOACs), especially after Covid-19 pandemic introduction note 97 Italian Medicines Agency (AIFA). By extraction all...