A5066930314- Endometriosis Research and Treatment
- Endometrial and Cervical Cancer Treatments
- Cancer-related molecular mechanisms research
- Uterine Myomas and Treatments
- MicroRNA in disease regulation
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ovarian cancer diagnosis and treatment
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Liver Disease Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Disease and Adiposity
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Reproductive Biology and Fertility
- Cardiovascular Effects of Exercise
- Infectious Disease Case Reports and Treatments
- Proteoglycans and glycosaminoglycans research
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Cancer Genomics and Diagnostics
- Cardiovascular Function and Risk Factors
- Vitamin D Research Studies
- Ferroptosis and cancer prognosis
Hospital General Universitario De Valencia
2019-2024
Fundación General
2019
Instituto de Investigación Sanitaria La Fe
2013-2018
Instituto Politécnico Nacional
2015
Leitat Technological Center
2014
Could an aberrant microRNA (miRNA) expression profile be responsible for the changes in angiogenic and fibrinolytic states observed endometriotic lesions?This study revealed characteristic miRNA profiles associated with endometriosis endometrial tissue lesions from same patient their correlation most important factors. WHAT IS ALREADY KNOWN?: An role dysregulated pathogenesis of is well documented. However, to best our knowledge, there are no reports relationship between factors miRNAs when...
Introduction High-grade serous ovarian cancer (HGSOC) is the second most frequent gynecological malignancy but lethal, partially due to spread of disease through peritoneal cavity. Recent evidence has shown that, apart from their role in immune defense phagocytosis and degranulation, neutrophils are able participate progression release neutrophil extracellular traps (NETs) a process called NETosis. NETs composed DNA, histones, calprotectin, myeloperoxidase (MPO) elastase NETosis been...
STUDY QUESTIONCould peritoneal fluid (PF) from patients with endometriosis alter the microRNA (miRNA) expression profile in endometrial and endometriotic cells patients?
Non-alcoholic fatty liver disease (NAFLD) appears to be a new risk factor for the development of coronary artery (CAD). Members class non-coding RNAs, termed microRNAs (miRNAs), have been identified as post-transcriptional regulators cholesterol homoeostasis and can contribute NAFLD. The aims this study were (i) assess relationship between NAFLD sudden cardiac death (SCD) from severe CAD in forensic autopsies (ii) quantify several hepatic miRNAs previously associated with lipid metabolism...
Endometriosis, defined as the presence of endometrium outside uterus, is one most frequent gynecological diseases. It has been suggested that modifications both endometrial and peritoneal factors could be implicated in this disease. Endometriosis a multifactorial disease which angiogenesis proteolysis are dysregulated. MicroRNAs (miRNAs) small non-coding RNAs regulate protein expression may main regulators angiogenesis. Our hypothesis fluid from women with endometriosis modify several miRNAs...
Ovarian cancer is the third most common gynaecological and has a very high mortality rate. The cornerstone of treatment complete debulking surgery plus chemotherapy. Even with treatment, 80% patients have recurrence. Circulating tumour DNA (ctDNA) been shown to be useful in control follow-up some tumours. It could an option define cytoreduction for early diagnosis
Purpose Our main objective is to evaluate the psychometric properties of Spanish version EHP-30 questionnaire. The secondary aim differences in scores core scales between patients with either surgical treatment or conservative management endometriosis.Methods Cross-sectional study conducted into a tertiary hospital endometriosis reference unit. All (n = 223) pre-surgically completed questionnaire, EQ-5D questionnaire 184) and visual analogue scale 210) for endometriosis-related pain....
Background: the association between ovarian endometriosis (OE) and endometriosis-associated cancer (EAOC) is extensively documented, misfunction of immune system might be involved. The primary objective this study was to identify compare spatial distribution tumour-infiltrating lymphocytes (TILs) tumour-associated macrophages (TAMs) in OE EAOC. Secondary objectives included analysis relationship immunosuppressive populations T-cell exhaustion markers both groups. Methods: TILs (CD3, CD4,...
Advanced ovarian cancer (AOC) requires an aggressive surgery with large visceral resections in order to achieve optimal or complete cytoreduction and increase the patient's survival. However, surgical aggressiveness treatment of AOC is not exempt from major complications, such as gastrointestinal fistula (GIF), which stands out among others due its high morbidity mortality.We evaluated clinicopathological features patients their association GI. Data for 107 who underwent primary debulking...
<h3>Introduction/Background</h3> High-grade serous ovarian cancer (HGSOC) is the most lethal gynecologic for which no curative treatment exists. miRNAs are small non-coding RNAs (18–21 nucleotides) that act as regulators of gene expression, reducing expression their target mRNAs. Accumulating evidence has shown epigenetic mechanisms, and DNA methylation, involved in pathogenesis human cancers, including HGSOC. We aimed to gain insight mechanisms HGSOC identify therapeutic targets....
High-grade serous ovarian cancer (HGSOC) is the most lethal form of gynecologic cancer, with limited treatment options and a poor prognosis. Epigenetic factors, such as microRNAs (miRNAs) DNA methylation, play pivotal roles in progression, yet their specific contributions to HGSOC remain insufficiently understood. In this study, we performed comprehensive high-throughput analyses identify dysregulated miRNAs investigate epigenetic regulation. Analysis tissue samples from advanced-stage...