A5039893319- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Acute Ischemic Stroke Management
- Barrier Structure and Function Studies
- Endometriosis Research and Treatment
- Liver physiology and pathology
- Proteoglycans and glycosaminoglycans research
- Immune Response and Inflammation
- Gut microbiota and health
- Neurological Disease Mechanisms and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Multiple Myeloma Research and Treatments
- Circadian rhythm and melatonin
- Clostridium difficile and Clostridium perfringens research
- S100 Proteins and Annexins
Research Institute Hospital 12 de Octubre
2024-2025
Universidad Complutense de Madrid
2024-2025
Hospital Universitario 12 De Octubre
2024
Universitat Politècnica de València
2021
Stroke is a leading cause of mortality and disability, driven by complex time-dependent mechanisms that aggravate ischemic damage. Recent evidence indicates infarct volumes fluctuate according to diurnal oscillations, both in mice humans, with worse outcomes during the inactive phase their circadian cycle. Here, we show neutrophils are responsible for these variations. By depleting or blocking clock, differences were abolished, suggesting number phenotype contribute Mechanistically, linked...
BACKGROUND: Acute ischemic stroke treatment typically involves tissue-type plasminogen activator (tPA) or tenecteplase, but about 50% of patients do not achieve successful reperfusion. The causes tPA resistance, influenced by thrombus composition and timing, are fully clear. Neutrophil extracellular traps (NETs), associated with poor outcomes reperfusion contribute to thrombosis. DNase-I, which degrades neutrophil traps, could improve thrombolytic efficacy. However, more studies needed...
ABSTRACT BACKGROUND. Ischemic stroke, a major cause of death and disability, triggers immune suppression inflammation, increasing the risk infections, particularly early post-stroke. These infections worsen outcomes, prolong hospitalization, lack reliable predictive protocols. Current management with broad-spectrum antibiotics is not proven effective may disrupt microbiota balance. Neutrophil elastase (NE), vital for defense, can exacerbate inflammation infection susceptibility. The main...
The development of three-dimensional environments to mimic the in vivo cellular response is a problem building disease models. This study aimed synthesize and validate support for culturing monoclonal plasma cells (mPCs) as model multiple myeloma. environment biomimetic microgel formed by alginate microspheres produced on microfluidic device whose surface has been functionalized layer-by-layer process with components bone marrow's extracellular matrix, which will interact mPC. As proof...
Bacterial infections are among the most common complications in stroke patients. While some factors triggering these well established, bacterial translocation (BT) from intestine to other organs represents another significant factor consider. In our study, we observed a high percentage of animals with intestinal barrier dysfunction (GBD) and BT following stroke, typical bacteria even detected lungs. Moreover, this process not only exacerbates peripheral/central inflammation but also...