Eduardo Villacorta
A5034650743- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Cardiovascular Effects of Exercise
- Infective Endocarditis Diagnosis and Management
- Congenital heart defects research
- Parathyroid Disorders and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Viral Infections and Immunology Research
- Cardiac pacing and defibrillation studies
- Antimicrobial Resistance in Staphylococcus
- Sarcoidosis and Beryllium Toxicity Research
- Pericarditis and Cardiac Tamponade
- Pulmonary Hypertension Research and Treatments
- Streptococcal Infections and Treatments
- Infectious Aortic and Vascular Conditions
- Acute Myocardial Infarction Research
- COVID-19 Clinical Research Studies
- Family and Patient Care in Intensive Care Units
- Aortic aneurysm repair treatments
- Long-Term Effects of COVID-19
Instituto de Investigación Biomédica de Salamanca
2015-2025
Universidad de Salamanca
2005-2025
Complejo Hospitalario de Salamanca
2018-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2018-2025
Centro de Investigación Biomédica en Red
2018-2025
Instituto de Salud Carlos III
2020-2024
Assistance Publique – Hôpitaux de Paris
2018-2024
Sorbonne Université
2024
Hospital Son Llatzer
2024
Health Research Institute of the Balearic Islands
2024
There is no agreement in the best cutoff time to distinguish between early- and late- onset prosthetic valve endocarditis (PVE). Our objectives are define early-onset PVE according microbiological spectrum analyse profile short-term prognosis of this entity.The 172 non-drug users, who were patients with PVE, compared elapsed from surgery among 640 diagnosed 1996 2004. differences occurred within 2 months replacement those accounting 12 months. The proportion coagulase-negative Staphylococci...
The Cardiomyopathy Registry of the EURObservational Research Programme is a prospective, observational, and multinational registry consecutive patients with four cardiomyopathy subtypes: hypertrophic (HCM), dilated (DCM), arrhythmogenic right ventricular (ARVC), restrictive (RCM). We report baseline characteristics management adults enrolled in registry. A total 3208 were by 69 centres 18 countries [HCM (n = 1739); DCM 1260); ARVC 143); RCM 66)]. Differences between subtypes (P < 0.001)...
Background: Truncating variants in the TTN gene (TTNtv) are commonest cause of heritable dilated cardiomyopathy. This study aimed to phenotypes and outcomes TTNtv carriers. Methods: Five hundred thirty-seven individuals (61% men; 317 probands) with were recruited 14 centers (372 [69%] baseline left ventricular systolic dysfunction [LVSD]). Baseline longitudinal clinical data obtained. The primary end point was a composite malignant arrhythmia end-stage heart failure. secondary reverse...
Abstract Aims The aim of this study was to determine the frequency heterozygous truncating ALPK3 variants (ALPK3tv) in patients with hypertrophic cardiomyopathy (HCM) and confirm their pathogenicity using burden testing independent cohorts family co-segregation studies. Methods results In a discovery cohort 770 index HCM, 12 (1.56%) were for ALPK3tv [odds ratio(OR) 16.11, 95% confidence interval (CI) 7.94–30.02, P = 8.05e−11] compared Genome Aggregation Database (gnomAD) population....
Variants in myosin heavy chain 7 (MYH7) are responsible for disease 1% to 5% of patients with dilated cardiomyopathy (DCM); however, the clinical characteristics and natural history MYH7-related DCM poorly described.We sought determine phenotype prognosis DCM. We also evaluated influence variant location on phenotypic expression.We studied data from 147 individuals DCM-causing MYH7 variants (47.6% female; 35.6 ± 19.2 years) recruited 29 international centers.At initial evaluation, 106...
Fabry disease (FD) is a X-linked rare lysosomal storage disorder caused by deficient α-galactosidase A (α-GalA) activity. Early diagnosis and the prediction of course are complicated clinical heterogeneity FD, as well frequently inconclusive biochemical genetic test results that do not correlate with course. We sought to identify potential biomarkers FD better understand underlying pathophysiology phenotypes. compared plasma proteomes 50 patients matched healthy controls using DDA SWATH-MS....
Aims Surgery in patients with infective endocarditis (IE) can be elective (upon completion of antibiotic treatment) or urgent (before treatment has ended) when the clinical course is unfavourable. However, surgery for left-sided associated high mortality. The aims this study were to describe profile who underwent and analyse factors that predicted Methods results Among 508 consecutive episodes IE, 391 89 required surgery. main reasons heart failure did not respond medication (72%) persistent...
The influence of age on the main epidemiological, clinical, echocardiographic, microbiological, and prognostic features patients with infective endocarditis remains unknown. We present series largest numbers range ages subjects to date that analyzes characteristics isolated left-sided endocarditis. Furthermore, this is first one in which have been distributed according quartile.A total 600 episodes consecutively diagnosed 3 tertiary centers were stratified into age-specific quartiles 107...
The genetic cause of hypertrophic cardiomyopathy remains unexplained in a substantial proportion cases. Formin homology 2 domain containing 3 (FHOD3) may have role the pathogenesis cardiac hypertrophy but has not been implicated cardiomyopathy. This study sought to investigate relation between FHOD3 mutations and development was sequenced by massive parallel sequencing 3,189 unrelated probands 2,777 patients with no evidence (disease control subjects). authors evaluated protein-altering...
Abstract Background Cardiac sequelae of past SARS-CoV-2 infection are still poorly documented. We conducted a cross-sectional study in health-care workers to report evidence pericarditis and myocarditis after infection. Methods studied 139 with confirmed (103 diagnosed by RT-PCR 36 serology). Participants underwent clinical assessment, electrocardiography, laboratory tests including immune cell profiling cardiac magnetic resonance (CMR). Pericarditis was when classical criteria were present,...
Disease penetrance in genotype-positive (G+) relatives of families with dilated cardiomyopathy (DCM) and the characteristics associated DCM onset these individuals are unknown. This study sought to determine new diagnosis G+ identify factors development. The authors evaluated 779 patients (age 35.8 ± 17.3 years; 459 [59%] females; 367 [47%] variants TTN) without followed at 25 Spanish centers. After a median follow-up 37.1 months (Q1-Q3: 16.3-63.8 months), 85 (10.9%) developed (incidence...
The interaction between common cardiovascular risk factors (CVRF) and hypertrophic cardiomyopathy (HCM) is poorly studied. We sought to explore the relation CVRF clinical characteristics of patients with HCM enrolled in EURObservational Research Programme (EORP) Cardiomyopathy registry.1739 were hypertension (HT), diabetes (DM), body mass index (BMI), traits was analysed. Analyses stratified according presence or absence a pathogenic variant sarcomere gene. prevalence HT, DM, obesity (Ob)...
Abstract Aims Late gadolinium enhancement (LGE) is frequently found in patients with dilated cardiomyopathy (DCM); there little information about its frequency and distribution pattern according to the underlying genetic substrate. We sought describe LGE patterns genotypes analyse risk of major ventricular arrhythmias (MVA) patterns. Methods results Cardiac magnetic resonance findings genetics were performed a cohort 600 DCM followed at 20 Spanish centres. After exclusion individuals...
Fabry disease (FD) is a rare X-linked lysosomal storage disorder caused by deficiency in the enzyme α-galactosidase A. This defect leads to progressive accumulation of glycosphingolipids, resulting kidney, heart, and nervous system damage, which contributes significant morbidity mortality. Early diagnosis essential prevent irreversible damage optimize treatment strategies. Recent research aims provide better understanding FD pathophysiology improve management approaches. study an...