A5022888598- Cardiovascular Function and Risk Factors
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Mechanical Circulatory Support Devices
- Transplantation: Methods and Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiomyopathy and Myosin Studies
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Cardiac electrophysiology and arrhythmias
- COVID-19 Clinical Research Studies
- Organ Transplantation Techniques and Outcomes
- Cardiovascular Disease and Adiposity
- Pericarditis and Cardiac Tamponade
- Congenital Heart Disease Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Syncope and Autonomic Disorders
- Takotsubo Cardiomyopathy and Associated Phenomena
- Atrial Fibrillation Management and Outcomes
- Infective Endocarditis Diagnosis and Management
- Long-Term Effects of COVID-19
Vall d'Hebron Institut de Recerca
2020-2025
Universitat Autònoma de Barcelona
2018-2025
Hebron University
2024-2025
Centro de Investigación Biomédica en Red
2021-2025
Centro de Investigación en Red en Enfermedades Cardiovasculares
2021-2025
Instituto de Salud Carlos III
2024-2025
Vall d'Hebron Hospital Universitari
2019-2025
University Health Network
2022-2025
Ted Rogers Centre for Heart Research
2022-2024
University of Toronto
2022-2023
Background Cardiogenic shock (CS) is a significant complication of Takotsubo syndrome (TTS), contributing to heightened mortality and morbidity. Despite this, the Society for Cardiovascular Angiography Interventions (SCAI) staging system CS severity lacks validation in patients with TTS CS. This study aimed characterize patient cohort using SCAI assess its utility cases complicated by Methods Results From national registry, 1591 consecutive were initially enrolled stratified into 5 stages (A...
Heat shock protein 90 (Hsp90) facilitates maturation and stability of HER2. Combining an Hsp90 inhibitor trastuzumab has demonstrated anti-tumor effects in patients with HER2+ breast cancer. Adults measurable, locally advanced or metastatic cancer prior treatment were enrolled a phase 2 trial employing weekly 300 mg/m2 retaspimycin HCl, potent inhibitor, 6 mg/kg every 3 weeks. A Simon’s two-stage design determined expansion by dose-limiting toxicity (DLT) response rates. Pharmacokinetics...
Studies in cardiogenic shock (CS) often have a heterogeneous population of patients, including those with acute myocardial infarction and decompensated heart failure (ADHF-CS). The therapeutic profile milrinone may benefit patients ADHF-CS. We compared the outcomes haemodynamic trends ADHF-CS receiving either or dobutamine.
Background: In Europe, there is greater acceptance of hearts from higher-risk donors for transplantation, whereas in North America, the donor heart discard rate significantly higher. A Donor Utilization Score (DUS) was used to compare European and American characteristics recipients included International Society Heart Lung Transplantation registry 2000 2018. DUS further evaluated as an independent predictor 1-year freedom graft failure, after adjusting recipient risk. Lastly, we assessed...
Abstract Background Cardiac magnetic resonance (CMR) is essential for diagnosing cardiomyopathy, serving as the gold standard assessing heart chamber volumes and tissue characterization. Hemodynamic forces (HDF) analysis, a novel approach using cine CMR images, estimates energy exchange between left ventricular (LV) wall blood. While prior research has focused on peak or mean longitudinal HDF values, this study aims to investigate whether unsupervised clustering of curves can identify...
Abstract Background Hypertrophic cardiomyopathy (HCM) is associated with an increased risk of major adverse cardiovascular events (MACE), however, current stratification methods are imperfect. Left atrial global longitudinal strain (LA GLS) increasingly acknowledged predictive parameter, yet its potential role in HCM not well defined. Purpose This study aims to investigate the prognostic cardiac magnetic resonance (CMR)-derived LA GLS for occurrence MACE patients HCM. Methods A...
Abstract Background Dilated cardiomyopathy (DCM) is associated with an increased risk of major adverse cardiovascular events (MACE). However, current stratification methods are imperfect. Left atrial global longitudinal strain (LA GLS) increasingly acknowledged predictive parameter, yet its potential role in DCM not well defined. Purpose This study aims to investigate the prognostic cardiac magnetic resonance (CMR)-derived LA GLS for occurrence MACE patients DCM. Methods A retrospective,...
Information on mid-term outcomes of percutaneous pulmonary valve replacement (PPVR) with the Edwards Sapien (ES) in native right ventricular outflow tract (RVOT) are limited. This study assesses 76 patients who underwent PPVR between 2016 and 2022, comparing (40.8%) non-native (59.2%) RVOTs. The primary endpoint was a composite endocarditis, reinterventions, cardiovascular death secondary included prosthetic dysfunction (PVD), tricuspid regurgitation (TR), ejection fraction (RVEF), indexed...
Abstract Aims The impact of sex on adverse left ventricular remodeling (LVR) after ST-elevation myocardial infarction (STEMI) is unclear due to conflicting results. This study sought establish sex-based differences in LVR using Cardiovascular Magnetic Resonance (CMR) among STEMI patients and their clinical outcomes. Methods results included with a first who underwent primary percutaneous coronary intervention (PCI). CMR was performed at 6 days (Interquartile range [IQR]: 4-9 days) months...
The COVID-19 pandemic has reduced access to endomyocardial biopsy (EMB) rejection surveillance in heart transplant (HT) recipients. This study is the first Canada assess role for noninvasive personalizing titration of immunosuppression and patient satisfaction post-HT.In this mixed-methods prospective cohort study, adult HT recipients more than 6 months from had their routine EMBs replaced by with gene expression profiling (GEP) donor-derived cell-free DNA (dd-cfDNA) testing. Demographics,...
BACKGROUND: Cardiac allograft vasculopathy (CAV) is the leading cause of late graft dysfunction in heart transplantation. Building on previous unsupervised learning models, we sought to identify CAV clusters using serial maximal intimal thickness and baseline clinical risk factors predict development early CAV. METHODS: This a single-center retrospective study including adult transplantation recipients. A latent class mixed-effects model was used patient with similar trajectories...
Total predicted heart mass (PHM) is the recommended metric to assess donor-recipient size matching in patients undergoing transplantation. Separately measuring right ventricular (RV) and left (LV) PHM may improve risk prediction of 1-year graft failure.Adult transplant recipients from UNOS database 2000 2018 were included study. LV RV modeled as restricted cubic splines. The association with failure was determined using adjusted Cox regression. reclassification both versus total assessed net...
590 Background: Retaspimycin hydrochloride (IPI-504) is a potent, intravenously-administered heat shock protein 90 (Hsp90) chaperone inhibitor. Hsp90 helps maintain the stability of key oncoproteins, including HER2. Preclinical studies have demonstrated activity IPI-504 plus trastuzumab in xenograft mouse models using trastuzumab-sensitive and trastuzumab-resistant HER2-positive cell lines. Methods: In our single-arm, phase 2 study, overall response rate tolerability pts with previously...