A5005047752- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Transplantation: Methods and Outcomes
- Cardiovascular Function and Risk Factors
- Organ Transplantation Techniques and Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Vitamin D Research Studies
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiac electrophysiology and arrhythmias
- Mesenchymal stem cell research
- Spondyloarthritis Studies and Treatments
- Metabolomics and Mass Spectrometry Studies
- Hemodynamic Monitoring and Therapy
- Congenital Heart Disease Studies
- Vitamin C and Antioxidants Research
- Tryptophan and brain disorders
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Stress Responses and Cortisol
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Rheumatoid Arthritis Research and Therapies
Duke Medical Center
2019-2025
Duke University
2018-2024
Duke University Hospital
2019-2024
Clinical Research Institute
2022-2023
National Institutes of Health
2016-2019
National Heart Lung and Blood Institute
2016-2019
Allegheny General Hospital
2016-2019
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2018
Jichi Medical University
2018
University of Arizona
2016-2017
BACKGROUND. Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham score (FRS). Immune dysregulation to a distinct subset proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring CV risk. This study assessed if LDGs are vivo vascular dysfunction and inflammation coronary plaque.
Background: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides ideal human model to study atherogenesis in vivo. We hypothesized that the increased cardiovascular observed psoriasis would be partially attributable elevated subclinical coronary artery burden composed noncalcified plaques high-risk features. However, inadequate efforts have been made directly measure this vulnerable population. As such, we sought compare total...
GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, disease associated with increased risk, provides a model to study biomarkers (CVD). Whether GlycA associates psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein is unknown.To investigate the relationships between CVD.Patients controls (n=412) participated 2-stage study. We measured by nuclear magnetic resonance spectroscopy. National...
Inflammation is critical in the development of atherosclerosis. Psoriasis a chronic inflammatory skin disease that associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography vivo and future cardiovascular events. It provides human model to understand effect treating target organ (eg, skin) on diseases.To investigate association between change severity at 1 year characterize impact anti-tumor necrosis factor therapy inflammation.In...
Inflammation is critical to atherosclerosis. Psoriasis, a chronic inflammatory disease associated with early cardiovascular events and increased aortic vascular inflammation (VI), provides model study the process of atherogenesis. Fludeoxyglucose F 18 positron emission tomography/computed tomography (18F-FDG PET/CT) helps quantify VI, coronary computed angiography artery (CAD) assessment through evaluation total plaque burden (TB) noncalcified (NCB), luminal stenosis, high-risk plaques...
Women comprise approximately one-third of the advanced heart failure population but may receive fewer therapies including left ventricular assist devices (LVADs). During early pulsatile-flow device era, women had higher post-LVAD mortality and increased complications. However, knowledge about these differences in continuous-flow era is limited. Therefore, we sought to explore temporal trends LVAD utilization by sex.Patients with implantation from 2004 2016 were identified using Nationwide...
Article1 April 1933The Heart in MyxedemaElectrocardiograms and Roentgen-Ray Measurements before after TherapyJ. LERMAN, M.D., R. J. CLARK, H. MEANS, F.A.C.P.J. F.A.C.P.Author, Article, Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-10-1251 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptREVIEW OF THE LITERATUREIn various articles textbooks dealing with myxedema, very little has been said regarding...
BACKGROUND: Heart transplant (HT) in recipients with left ventricular assist devices (LVADs) is associated poor early post-HT outcomes, including primary graft dysfunction (PGD). As complicated heart explants LVADs may produce longer ischemic times, innovations donor preservation yield improved outcomes. The SherpaPak Cardiac Transport System an organ technology that maintains temperatures between 4 °C and 8 °C, which minimize cold-induced injuries. This analysis sought to identify whether...
Psoriasis, a chronic inflammatory skin disease associated with accelerated noncalcified coronary burden (NCB) by computed tomography angiography (CCTA), accelerates lipoprotein oxidation in the form of oxidized modified lipoproteins. A transmembrane scavenger receptor for these lipoproteins is lectinlike low-density receptor-1 (LOX-1), which has been reported to be artery disease. It unknown whether this psoriasis.To assess association between soluble LOX-1 (sLOX-1) and NCB psoriasis over...
Subjects with SLE display an enhanced risk of atherosclerotic cardiovascular disease (CVD) that is not explained by Framingham risk. This study sought to investigate the utility nuclear MR (NMR) spectroscopy measurements serum lipoprotein particle counts and size glycoprotein acetylation (GlycA) burden predict coronary atherosclerosis in SLE. Coronary plaque was assessed subjects healthy controls using CT angiography. Lipoproteins GlycA were quantified NMR spectroscopy. displayed...
Pulmonary embolism (PE) is a major cause of cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA) increasingly recognized in the aging population, especially with rising obesity epidemic. The impact OSA on inpatient mortality PE not well understood. We used Nationwide Inpatient Sample databases from 2005 to 2016 identify 755,532 acute patients (age≥18 years). Among these, 61,050 (8.1%) were OSA+. Temporal trends length stay, mortality, its association analyzed. proportion who...
Abstract Heart failure with reduced ejection fraction (HFrEF) is increasingly treated medications for type 2 diabetes mellitus (T2DM). Whether metabolic derangements in HFrEF and T2DM are associated differential outcomes remains unclear. Therefore, understanding molecular pathways their effects on clinical endpoints important. The FIGHT trial randomized 300 individuals a recent HF hospitalization to liraglutide (a GLP-1 receptor agonist) versus placebo assess mortality, rehospitalization,...