A5033787787- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Health and Risk Factors
- Psoriasis: Treatment and Pathogenesis
- Health disparities and outcomes
- Cholesterol and Lipid Metabolism
- Tryptophan and brain disorders
- Cell Adhesion Molecules Research
- Stress Responses and Cortisol
- Obesity, Physical Activity, Diet
- Adipokines, Inflammation, and Metabolic Diseases
- Systemic Lupus Erythematosus Research
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- Urban Transport and Accessibility
- Diet and metabolism studies
- Barrier Structure and Function Studies
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Smoking Behavior and Cessation
- Mobile Health and mHealth Applications
- Hormonal Regulation and Hypertension
- Glaucoma and retinal disorders
- Adipose Tissue and Metabolism
- Birth, Development, and Health
National Institutes of Health
2017-2024
National Heart Lung and Blood Institute
2016-2024
University of Hawaiʻi at Mānoa
2011-2020
University of Hawaii System
2013-2020
University of Arizona
2017
Blood Systems Research Institute
2016
Kazan Federal University
2013-2014
University of Amsterdam
2014
Chung-Ang University
2014
Kyushu University
2014
The use of biologic therapy has increased over the past decade well beyond primary autoimmune diseases. Indeed, a recent trial using an anti-IL-1beta antibody reduced second myocardial infarction (MI) in those who have had MI. Psoriasis is chronic inflammatory disease often treated with biologics when severe, associated risk MI, part driven by high-risk coronary plaque phenotypes computed tomography angiography (CCTA). We hypothesized that we would observe reduction inflammatory-driven...
Abstract Endothelial cells (EC) play a key role in atherosclerosis. Although EC are constant contact with low density lipoproteins (LDL), how process LDL and whether this influences atherogenesis, is unclear. Here we show that take up metabolize LDL, when overburdened intracellular cholesterol, generate cholesterol crystals (CC). The CC deposited on the basolateral side, compromise endothelial function. When hyperlipidemic mice given high fat diet, appear aortic sinus within 1 week....
Inflammation is critical in the development of atherosclerosis. Psoriasis a chronic inflammatory skin disease that associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography vivo and future cardiovascular events. It provides human model to understand effect treating target organ (eg, skin) on diseases.To investigate association between change severity at 1 year characterize impact anti-tumor necrosis factor therapy inflammation.In...
Macrophage foam cell formation is a key feature of atherosclerosis. Recent studies have shown that specific microRNAs (miRs) are regulated in modified low-density lipoprotein-treated macrophages, which can affect the cellular cholesterol homeostasis. Undertaking genome-wide screen miRs primary macrophages by lipoprotein, miR-302a emerged as potential candidate may play role macrophage homeostasis.The objective this study was to assess involvement lipid homeostasis and if it influence...
Abstract Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, chronic inflammatory skin disease associated with increased susceptibility to atherosclerosis, provides clinical model that can be utilized investigate the links between and atherosclerosis development. We sought key biological processes in psoriasis vascular tissue identify components may promote conditions....
Abstract Barrier stabilizing effects of cAMP as well the small GTPase Rac 1 are established. Moreover, it is generally believed that permeability‐increasing mediators such thrombin disrupt endothelial barrier functions primarily via activation Rho A. In this study, we provide evidence decrease both levels and activity contribute to thrombin‐mediated breakdown. Treatment human dermal microvascular cells (HDMEC) with 1‐inhibitor NSC‐23766 decreased transendothelial electrical resistance (TER)...
Atherosclerosis and vascular remodeling after injury are driven by inflammation mononuclear cell infiltration. Extracellular RNA (eRNA) has recently been implicated to become enriched at sites of tissue damage act as a proinflammatory mediator. Here, we addressed the role eRNA in high-fat diet-induced atherosclerosis neointima formation atherosclerosis-prone mice.The presence was revealed atherosclerotic lesions from diet-fed low-density lipoprotein receptor-deficient (Ldlr(-/-)) mice...
IL-32 is a multifaceted cytokine with role in infections, autoimmune diseases, and cancer, it exerts diverse functions, including aggravation of inflammation inhibition virus propagation. We previously identified as critical regulator endothelial cell (EC) we now reveal that also possesses angiogenic properties. The hyperproliferative ECs human pulmonary arterial hypertension glioblastoma multiforme exhibited markedly increased abundance IL-32, and, significantly, the colocalized integrin...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
Inflammation is critical to atherosclerosis. Psoriasis, a chronic inflammatory disease associated with early cardiovascular events and increased aortic vascular inflammation (VI), provides model study the process of atherogenesis. Fludeoxyglucose F 18 positron emission tomography/computed tomography (18F-FDG PET/CT) helps quantify VI, coronary computed angiography artery (CAD) assessment through evaluation total plaque burden (TB) noncalcified (NCB), luminal stenosis, high-risk plaques...
Little is known about the spatial clustering of neighborhood deprivation across United States (US). Using data from 2010 US Census Bureau, we created a index (NDI: higher NDI indicates deprivation/ lower socioeconomic status) for each county within County level scores were loaded into ArcGIS 10.5.1 where they mapped and analyzed using Moran's I Anselin Local I. Ultimately, varies spatially US. The highest found in Southeastern Southwestern states, inland regions Southern California. This...
Psoriasis is a systemic inflammatory skin disease associated with cardiovascular and lipid dysfunction. However, traditional parameters have limited prognostic value, whereas assessing oxidation-modified lipids in this driven condition may capture additional risk. Recently, study showed that psoriasis was increased lipid-rich coronary plaques; therefore, investigating potential relationships speed understanding of psoriasis.To understand whether associate phenotypes, cardiometabolic...
Adoptive transfer of natural killer (NK) cells can induce remission in patients with relapsed/refractory leukemia and myeloma. However, to date, clinical efficacy NK cell immunotherapy has been limited a sub-fraction patients. Here we show that steps incorporated the ex vivo manipulation/production products used for adoptive infusion, such as over-night IL-2 activation or cryopreservation followed by expansion, drastically decreases surface expression bone marrow (BM) homing chemokine...
The use of scanning electron microscopy and transmission to elucidate the role cholesterol crystals in atherosclerotic plaque rupture is discussed.
Addressing the need for more equitable cardio-oncology care requires attention to existing disparities in cardio-oncologic disease prevention and outcomes. This is particularly important among those affected by adverse social determinants of health (SDOH). The intricate relationship SDOH, cancer diagnosis, outcomes from cardiotoxicities associated with oncologic therapies influenced sociopolitical, economic, cultural factors. Furthermore, mechanisms cell signaling epigenetic effects on gene...
Objectives: To determine whether cyclic adenosine monophosphate (cAMP) is critically involved in lipopolysaccharide (LPS)-induced breakdown of endothelial barrier functions vivo and vitro. Design: Experimental laboratory research. Setting: Research laboratory. Subjects: Wistar rats cultured human microvascular cells. Intervention: Permeability measurements single postcapillary venules permeability cell biology techniques Measurements Results: We demonstrate that within 120 minutes LPS...
CXCR4-positive bone marrow cells (BMCs) are critically involved in cardiac repair mechanisms contributing to preserved function. Stromal cell-derived factor-1 (SDF-1) is the most prominent BMC homing factor known augment engraftment, which a limiting step of stem cell-based therapy. After myocardial infarction, SDF-1 expression rapidly upregulated and promotes repair.We have established bifunctional protein consisting an domain glycoprotein VI (GPVI) with high binding affinity receptor CXCR4...
Abstract CD36 requires palimitoylation in a selenoprotein K-dependent manner, to localize lipid rafts and function properly. Selk is an ER transmembrane protein important for calcium flux macrophage activation, but its role foam cell formation atherosclerosis has not been evaluated. BMDMs from Selk−/− mice exhibited decreased uptake of modLDL compared with WT controls, the differences were eliminated anti-CD36 blocking antibody. expression was TNF-α-stimulated controls. Fluorescence...
Inflammation is critical to atherogenesis. Psoriasis a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides compelling model understand potential pathways linking these diseases. A murine capturing the vascular metabolic diseases psoriasis would accelerate our understanding provide platform test emerging therapies. We aimed characterize new of inflammation (Rac1V12) from cardiovascular standpoint identify novel atherosclerotic signaling modulated...
Persistent skin inflammation and impaired resolution are the main contributors to psoriasis associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), docosahexaenoic (DHA), known exert beneficial effects on inflammatory response lipid function. However, a specific role of omega-3 PUFAs in accompanied pathologies still matter debate. Here, we carried out direct comparison between EPA DHA 12 weeks diet intervention treatment...