A5018628625- Fatty Acid Research and Health
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adaptive Control of Nonlinear Systems
- Eicosanoids and Hypertension Pharmacology
- Advanced Algorithms and Applications
- Drug Transport and Resistance Mechanisms
- Cancer, Lipids, and Metabolism
- EEG and Brain-Computer Interfaces
- Power Systems and Renewable Energy
- Smart Grid and Power Systems
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Stability and Control of Uncertain Systems
- Adipokines, Inflammation, and Metabolic Diseases
- Cryospheric studies and observations
- High-Voltage Power Transmission Systems
- Power Systems and Technologies
- Pharmacological Effects and Toxicity Studies
- Neural Networks and Applications
- Integrated Energy Systems Optimization
- Lipid metabolism and disorders
- Enzyme-mediated dye degradation
- Advanced Control Systems Optimization
- Lipid metabolism and biosynthesis
Chinese Academy of Medical Sciences & Peking Union Medical College
2010-2024
National Heart Lung and Blood Institute
2016-2024
Jianghan University
2012-2024
National Institutes of Health
2016-2024
China Aerospace Science and Industry Corporation (China)
2024
Government of the United States of America
2023
Shandong Academy of Sciences
2021-2022
Qilu University of Technology
2021-2022
Nippon Suisan Kaisha (Japan)
2011-2021
NARI Group (China)
2007-2021
Studies have demonstrated the beneficial effect of palmitoleic acid (C16:1 n-7) on reducing muscle insulin resistance and preventing beta-cell apoptosis. However, diabetes remains to be elucidated. The aim this study was examine antidiabetic in KK-Ay mice, a spontaneous model for studies obese type 2 with low sensitivity.KK-Ay mice were orally administered vehicle, 300 mg/kg acid, or palmitic (C16:0) daily basis 4 weeks.Palmitoleic reduced body weight increase, ameliorated development...
The current coronavirus disease 2019 (COVID-19) pandemic presents a global challenge for managing acutely ill patients and complications from viral infection. Systemic inflammation accompanied by "cytokine storm," hemostasis alterations severe vasculitis have all been reported to occur with COVID-19, emerging evidence suggests that dysregulation of lipid transport may contribute some these complications. Here, we aim summarize the understanding potential mechanisms related COVID-19...
Oxygen isotopic ratios (δ 18 O) of precipitation samples collected over several years at three meteorological stations on the northern Tibetan Plateau were used to conduct first investigation relationship between δ O and contemporaneous air temperatures ( T a ). Inferring past from measured in recently acquired ice cores necessitates establishing whether O‐ exists. For each station strong temporal is found , particularly for monthly averages which remove synoptic‐scale influences such as...
Frequent consumption of a diet high in fat and sucrose contributes to lifestyle-related diseases. However, limited information is available regarding the short-term effects such on onset obesity-associated metabolic abnormalities.Male C57BL/6 J mice were divided into two groups fed standard chow (control group) or fat-high containing 21% 34% (HF-HS for 2 4 weeks.The HF-HS significantly induced body weight gain beginning at week 1 similarly increased mesenteric white adipose tissue plasma...
Increasing evidence suggests that neutrophil extracellular traps (NETs) may play a role in promoting atherosclerotic plaque lesions humans and murine models. The exact pathways involved NET-driven atherogenesis remain to be systematically characterized. To assess the extent which myeloid-specific peptidylarginine deiminase 4 (PAD4) PAD4-dependent NET formation contribute atherosclerosis, mice with deletion of PAD4 were generated backcrossed Apoe-/- mice. kinetics atherosclerosis development...
While serum-circulating complement destroys invading pathogens, intracellularly active complement, termed the “complosome,” functions as a vital orchestrator of cell-metabolic events underlying T cell effector responses. Whether intracellular is also nonredundant for activity myeloid immune cells currently unknown. Here, we show that monocytes and macrophages constitutively express component (C) 5 generate autocrine C5a via formation an C5 convertase. Cholesterol crystal sensing by induced...
A high glycemic index (HGI) diet induces hyperglycemia, a risk factor for diseases affecting multiple organ systems. Here, we evaluated tissue-specific adaptations in the liver and retina after feeding HGI to mice 1 or 12 month. In liver, genes associated with inflammation fatty acid metabolism were altered within month of diet, whereas 12-month diet-fed group showed dysregulated expression cytochrome P450 overexpression lipogenic factors including
Scope Palmitoleic acid (palmitoleate; C16:1 n‐7), an omega‐7 monounsaturated fatty (MUFA) found in plants and marine sources, has been shown to favorably modulate lipid glucose metabolism. However, its impact on atherosclerosis not examined detail. Methods Results LDL receptor knock out (LDLR‐KO) mice are fed a Western diet supplemented with 5% (w/w) palmitoleate concentrate, oleic‐rich olive oil, or none (control) for 12 weeks. Dietary increases hepatic levels, improves plasma...
Both monounsaturated fatty acids (MUFAs) and polyunsaturated (PUFAs) play important roles in lipid metabolism, diets enriched with either of these two are associated decreased cardiovascular risk. Conventional soybean oil (CSO), a common food ingredient, predominantly contains linoleic acid (LA; C18:2), n-6 PUFA. Recently, modified (MSO) oleic (C18:1), n-9 MUFA, has been developed, because its improved chemical stability to oxidation. However, the effect different dietary oils on disease...
Persistent skin inflammation and impaired resolution are the main contributors to psoriasis associated cardiometabolic complications. Omega-3 polyunsaturated fatty acids (PUFAs), eicosapentaenoic acid (EPA), docosahexaenoic (DHA), known exert beneficial effects on inflammatory response lipid function. However, a specific role of omega-3 PUFAs in accompanied pathologies still matter debate. Here, we carried out direct comparison between EPA DHA 12 weeks diet intervention treatment...
Abstract Loss of a kidney results in compensatory growth the remaining kidney, phenomenon considerable clinical importance. However, mechanisms involved are largely unknown. Here, we use multi-omic approach unilateral nephrectomy model male mice to identify signaling processes associated with renal hypertrophy, demonstrating that lipid-activated transcription factor peroxisome proliferator-activated receptor alpha (PPARα) is an important determinant proximal tubule cell size and likely...
The objective of present study was to examine the effect long-chain monounsaturated fatty acids (LC-MUFAs) with chain lengths longer than 18 (i.e., C20:1 and C22:1 isomers combined) on obesity-related metabolic dysfunction its molecular mechanisms. Type-2 diabetic KK-Ay mice (n = 20) were randomly assigned 7% soybean oil-diet group (control group) 4% LC-MUFA concentrate-supplemented-diet (LC-MUFA group). At 8 weeks diet, results showed that plasma, liver adipose tissue levels increased...
Background: Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) have both shared different cardiovascular effects, commonly used fish oil supplements considerably varied EPA/DHA ratios. Aims: We compared the effects of with ratios on lipoprotein metabolism. Methods: In a double-blind, randomized cross-over study, normolipidemic adults (n = 30) consumed 12 g/day EPA-rich (EPA/DHA: 2.3) or DHA-rich 0.3) for 8-weeks, separated by an 8-week washout period. Results: Both similarly lowered...
The aim of this study was to elucidate the effect fish-oil-derived monounsaturated fatty acids (MUFAs) containing large amounts C20:1 and C22:1 isomers on metabolic disorders in mice. Male C57BL/6J mice were fed a 32% lard diet (control) or 27% plus 5% saury-oil-derived MUFA for 6 weeks. Dietary improved insulin resistance alleviated syndrome risk factors by reducing blood glucose lipids. These favorable changes may be attributed an adipocytokine profile. ingestion resulted mRNA expression...
To better mine the effective information contained in massive data and improve accuracy of short-term load forecasting, this paper proposes a hybrid model based on convolutional neural network long memory (CNN-LSTM) for forecasting (STLF), which takes historical data, meteorological date information, peak-valley electric price as input by constructing continuous feature maps with time sliding window. Convolutional (CNN) is used to extract features reshape them into vectors. The vectors are...
Oxygen-isotope ratios ( δ 18 O) measured on ice cores the Qinghai-Tibetan Plateau, China, increased by 1.2-2.2‰ from 1960s to 1990s. Measurements of O content precipitation and simultaneous air temperatures needed compute temperature increase corresponding in are currently made at Delingha Meteorological Station, but amount data is not yet sufficient obtain a reliable result.