A5066516536- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Lipoproteins and Cardiovascular Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Spondyloarthritis Studies and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Vitamin C and Antioxidants Research
- HIV-related health complications and treatments
- S100 Proteins and Annexins
- Cardiovascular Disease and Adiposity
- Health Systems, Economic Evaluations, Quality of Life
- Fatty Acid Research and Health
- Diabetes Management and Research
- Lipid metabolism and disorders
- Immune Response and Inflammation
- Cytokine Signaling Pathways and Interactions
- Inflammasome and immune disorders
- Cerebrovascular and Carotid Artery Diseases
- Diabetes and associated disorders
- Stress Responses and Cortisol
- Inflammatory mediators and NSAID effects
- Asthma and respiratory diseases
National Institutes of Health
2015-2024
National Heart Lung and Blood Institute
2015-2024
MedStar Washington Hospital Center
2020
Georgetown University
2020
MedStar Georgetown University Hospital
2020
Georgetown-Howard Universities Center for Clinical and Translational Science
2019
Jichi Medical University
2018
University of Arizona
2016-2017
Kaiser Permanente
2017
Los Angeles Medical Center
2017
The use of biologic therapy has increased over the past decade well beyond primary autoimmune diseases. Indeed, a recent trial using an anti-IL-1beta antibody reduced second myocardial infarction (MI) in those who have had MI. Psoriasis is chronic inflammatory disease often treated with biologics when severe, associated risk MI, part driven by high-risk coronary plaque phenotypes computed tomography angiography (CCTA). We hypothesized that we would observe reduction inflammatory-driven...
Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably luminal plaque, but it unclear whether these associations are attributable direct anti-inflammatory effects on the arteries.To investigate association of biologic inflammation in patients using perivascular fat attenuation index (FAI), novel imaging biomarker that assesses by mapping spatial changes...
BACKGROUND. Systemic lupus erythematosus (SLE) is associated with enhanced risk of atherosclerotic cardiovascular disease not explained by Framingham score (FRS). Immune dysregulation to a distinct subset proinflammatory neutrophils (low density granulocytes; LDGs) may play key roles in conferring CV risk. This study assessed if LDGs are vivo vascular dysfunction and inflammation coronary plaque.
Abstract Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute to this enhanced CVD risk. In animal models, the Janus kinase (JAK) inhibitor tofacitinib improves clinical features, immune dysregulation and vascular dysfunction. We conducted a randomized, double-blind, placebo-controlled trial SLE subjects (ClinicalTrials.gov NCT02535689). study, 30 are randomized...
The insulin-like growth factor (IGF) type 1 receptor is required for growth, transformation, and protection from apoptosis. IGFs can enhance cell migration, which known to be influenced via regulation of the E-cadherin/β-catenin complex. We sought investigate whether IGF-1 modulated interaction between E-cadherin β-catenin in human colorectal cancer cells. used C10 line, we established have previously shown lack adenomatous polyposis coli, E-cadherin, or mutations. found that stimulation...
The type 1 insulin-like growth factor receptor (IGF1R) is often overexpressed by tumors and mediates apoptosis protection. We previously showed that antisense reagents complementary to the IGF1R translation start site enhance radio- chemosensitivity impair Atm function. However these agents induce relatively modest down-regulation affect insulin levels. To identify alternative sites for molecular targeting, we utilized scanning oligonucleotide arrays probe secondary structure of mRNA. This...
Objective— To understand whether directly measured psoriasis severity is associated with vascular inflammation assessed by 18 F-fluorodeoxyglucose positron emission tomography computed tomography. Approach— In-depth cardiovascular and metabolic phenotyping was performed in adult patients (n=60) controls (n=20). Psoriasis using area index. Vascular average aortic target-to-background ratio Results— Both the (28 men 32 women, mean age 47 years) (13 7 41 were young low risk. index scores...
Background: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides ideal human model to study atherogenesis in vivo. We hypothesized that the increased cardiovascular observed psoriasis would be partially attributable elevated subclinical coronary artery burden composed noncalcified plaques high-risk features. However, inadequate efforts have been made directly measure this vulnerable population. As such, we sought compare total...
Background: Psoriasis is a chronic inflammatory disease associated with dyslipidemia, cardiovascular events, and mortality. We aimed to assess compare the effect of treatment moderate-to-severe psoriasis adalimumab or phototherapy on vascular inflammation biomarkers. Methods Results: Randomized, double-blind, trial adalimumab, phototherapy, placebo (1:1:1) for 12 weeks, crossover 52 weeks total. Outcomes included by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography...
Background Potent anti‐inflammatory rheumatoid arthritis (RA) treatments are associated with reduced cardiovascular risk as well increases in low‐density lipoprotein ( LDL ) cholesterol. This apparent paradox may be explained by favorable changes other lipid measurements. The objective of this study was to determine the longitudinal association between inflammation advanced measurements and high‐density HDL cholesterol efflux capacity. Methods Results We conducted a RA cohort from large...
GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, disease associated with increased risk, provides a model to study biomarkers (CVD). Whether GlycA associates psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein is unknown.To investigate the relationships between CVD.Patients controls (n=412) participated 2-stage study. We measured by nuclear magnetic resonance spectroscopy. National...
Inflammation is critical in the development of atherosclerosis. Psoriasis a chronic inflammatory skin disease that associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography vivo and future cardiovascular events. It provides human model to understand effect treating target organ (eg, skin) on diseases.To investigate association between change severity at 1 year characterize impact anti-tumor necrosis factor therapy inflammation.In...
Abstract Chronic inflammation is a critical component of atherogenesis, however, reliable human translational models aimed at characterizing these mechanisms are lacking. Psoriasis, chronic inflammatory skin disease associated with increased susceptibility to atherosclerosis, provides clinical model that can be utilized investigate the links between and atherosclerosis development. We sought key biological processes in psoriasis vascular tissue identify components may promote conditions....
Psoriasis is a T helper type 17 autoimmune disease associated with an increased risk cardiovascular events and mortality. Ustekinumab, antibody to p40, blocks cytokines IL-12 IL-23, highly effective safe treatment for psoriasis. We conducted randomized double-blinded placebo-controlled trial determine the effect of ustekinumab on aortic vascular inflammation (AVI) measured by imaging, key biomarkers inflammation, lipid, glucose metabolism in blood patients moderate-to-severe A total 43 were...
Background: Lipid-rich necrotic core (LRNC), a high-risk coronary plaque feature assessed by computed tomography angiography, is associated with increased risk of future cardiovascular events in patients subclinical, nonobstructive artery disease. Psoriasis chronic inflammatory condition that prevalence and events. This study characterized LRNC psoriasis how modulates response to biologic therapy. Methods: Consecutive naïve (n=209) underwent angiography at baseline 1-year assess changes...
The Abl-interactor (Abi) family of adaptor proteins has been linked to signaling pathways involving the Abl tyrosine kinases and Rac GTPase. Abi localize sites actin polymerization in protrusive membrane structures regulate dynamics vitro. Here we demonstrate that Abi2 modulates cell morphogenesis migration vivo. Homozygous deletion murine abi2 produced abnormal phenotypes eye brain, tissues with highest expression. In absence Abi2, secondary lens fiber orientation were defective eye,...
Adherens junctions are calcium-dependent cell–cell contacts that link neighboring cells through cadherin receptors. Coordinated regulation of the actin cytoskeleton by Rho GTPases is required for formation and dissolution adherens junctions. However, pathways signaling to cytoskeletal remain poorly defined. Here we identify Abl family kinases as critical mediators cadherin-mediated adhesion. Endogenous kinases, Arg, activated Rac activation after engagement regulate maintenance in mammalian...
Cholesterol efflux capacity (CEC) was recently shown to predict future cardiovascular (CV) events. Psoriasis both increases CV risk and impairs CEC. However, whether having poor CEC is associated with coronary plaque burden currently unknown. We aimed assess the cross-sectional relationship between assessed by quantitative computed tomography angiography (CCTA) in a well-phenotyped psoriasis cohort. Total non-calcified (NCB) indices were 101 consecutive patients using software. quantified...
Previous studies have demonstrated an interaction between sorting nexin 17 and the L2 capsid proteins from a variety of papillomavirus types. This is required for late endosomal trafficking protein entry L2/DNA complex into nucleus during infection. Here we show related PX-FERM family member 27 (SNX27), which mediated in part by novel PDZ domain SNX27 sequences central portion L2. The direct and, unlike that with SNX17, variable strength depending on type. We small interfering RNA...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...