A5044785633- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- T-cell and B-cell Immunology
- S100 Proteins and Annexins
- Immune Cell Function and Interaction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Spondyloarthritis Studies and Treatments
- Biomarkers in Disease Mechanisms
- Vitamin D Research Studies
- Sirtuins and Resveratrol in Medicine
- Immune Response and Inflammation
- Metabolism, Diabetes, and Cancer
- Systemic Lupus Erythematosus Research
- Antioxidant Activity and Oxidative Stress
- Asthma and respiratory diseases
- Immune cells in cancer
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- interferon and immune responses
- IL-33, ST2, and ILC Pathways
National Heart Lung and Blood Institute
2014-2019
National Institutes of Health
2014-2019
Englewood Hospital and Medical Center
2014-2015
National Institute of Arthritis and Musculoskeletal and Skin Diseases
2015
National Cancer Institute
2015
Washington Hospital
2015
University of Pennsylvania
2015
Skidmore College
2013-2015
Objective— To understand whether directly measured psoriasis severity is associated with vascular inflammation assessed by 18 F-fluorodeoxyglucose positron emission tomography computed tomography. Approach— In-depth cardiovascular and metabolic phenotyping was performed in adult patients (n=60) controls (n=20). Psoriasis using area index. Vascular average aortic target-to-background ratio Results— Both the (28 men 32 women, mean age 47 years) (13 7 41 were young low risk. index scores...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
Adipose tissue normally contains immune cells that regulate adipocyte function and contribute to metabolic disorders including obesity diabetes mellitus. Psoriasis is associated with increased risk for disease, which may in part be due adipose dysfunction, has not been investigated psoriasis. There currently no standardized method immunophenotyping human tissue. In prior studies, characteristic phenotypic markers of cell populations identified animal models or other tissues have applied a...
The superoxide dismutase mimetic manganese [III] tetrakis [5,10,15,20]-benzoic acid porphyrin (MnTBAP) is a potent antioxidant compound that has been shown to limit weight gain during short-term high fat feeding without preventing insulin resistance. However, whether MnTBAP therapeutic potential treat pre-existing obesity and resistance remains unknown. To investigate this, mice were treated with or vehicle the last five weeks of 24-week diet (HFD) regimen. treatment significantly decreased...
Purpose: Autoimmune retinopathy (AIR) is a associated with unexplained vision loss presumably linked to circulating antiretinal antibodies; currently, however, there are no standardized criteria regarding the diagnosis, treatment strategy, or pathogenesis of this disease. The importance B-lymphocyte immunophenotyping in classification AIR unknown. Methods: We utilized 15-color multiparametric flow cytometry identify aberrations B cell subsets that may contribute pathophysiology AIR. Luminex...
Interleukin-17A (IL-17A) is a potent pro-inflammatory cytokine that has been implicated in the pathogenesis of various autoimmune diseases. The production IL-17A commonly associated with subsets CD4+ T cells (Th17) and CD8+ (Tc17). Identifying these based on intracellular expression IL-17 or transcription factor RORC precludes isolation viable Th17 Tc17 there by limits studies involving cell-cell interaction cellular functions. Therefore, identifying surface markers can help enriching...
Introduction: Psoriasis is a chronic inflammatory disorder of the skin affecting 2-4% population and associated with an increased risk cardiovascular events, specifically myocardial infarction. Methods: In large, ongoing prospective cohort study psoriasis diseases (NCT01778569), we studied consecutive sample (n=100) aimed to investigate potential role that S100A8/A9 may have in linking CV disease measured by FDG PET CT coronary CTA. Furthermore, conducted vitro experiments on human aortic...
Obesity is a prevalent metabolic disease that associated with increased reactive oxygen species and oxidative stress. The purpose of this study was to determine if the superoxide dismutase mimetic manganese tetrakis benzoic acid porphyrin (MnTBAP) can attenuate obesity obesity-associated dysfunction. Mice were treated MnTBAP or vehicle during last five weeks 24 week high fat diet (HFD) regimen. Energy homeostasis, insulin sensitivity, adipose macrophage infiltrates, protein kinase B (PKB)...
The purpose of this study was to determine if manganese tetrakis benzoic acid porphyrin (MnTBAP) treatment reduces adiposity and increases bio‐markers for mitochondrial biogenesis. Male C57B6 mice were fed a low fat diet (LFD) or high (HFD) five months. During the last 30 days dietary intervention, given intraperitoneal injections MnTBAP (10 mg/kg/day) vehicle. significantly decreased body weight (52.8±2 vs. 40.1±2.1) epididymal white adipose tissue (EWAT) (2.53±0.11 1.47±0.13). PGC‐1α...