A5025791584- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Systemic Lupus Erythematosus Research
- Vitamin D Research Studies
- Spondyloarthritis Studies and Treatments
- Vitamin C and Antioxidants Research
- Health Systems, Economic Evaluations, Quality of Life
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammasome and immune disorders
- Cerebrovascular and Carotid Artery Diseases
- Cytokine Signaling Pathways and Interactions
- Biomarkers in Disease Mechanisms
- Stress Responses and Cortisol
- Cardiovascular Disease and Adiposity
- Antioxidant Activity and Oxidative Stress
- S100 Proteins and Annexins
- Rheumatoid Arthritis Research and Therapies
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Immune Response and Inflammation
- Computational Drug Discovery Methods
- Health, psychology, and well-being
- Sarcoidosis and Beryllium Toxicity Research
National Heart Lung and Blood Institute
2016-2023
National Institutes of Health
2016-2023
MedStar Washington Hospital Center
2020
MedStar Georgetown University Hospital
2020
Georgetown University
2020
Jichi Medical University
2018
University of Arizona
2016-2017
Kaiser Permanente
2017
Los Angeles Medical Center
2017
Allegheny General Hospital
2016
The use of biologic therapy has increased over the past decade well beyond primary autoimmune diseases. Indeed, a recent trial using an anti-IL-1beta antibody reduced second myocardial infarction (MI) in those who have had MI. Psoriasis is chronic inflammatory disease often treated with biologics when severe, associated risk MI, part driven by high-risk coronary plaque phenotypes computed tomography angiography (CCTA). We hypothesized that we would observe reduction inflammatory-driven...
Psoriasis is a chronic inflammatory skin disease associated with increased coronary plaque burden and cardiovascular events. Biologic therapy for psoriasis has been found to be favorably luminal plaque, but it unclear whether these associations are attributable direct anti-inflammatory effects on the arteries.To investigate association of biologic inflammation in patients using perivascular fat attenuation index (FAI), novel imaging biomarker that assesses by mapping spatial changes...
Background: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides ideal human model to study atherogenesis in vivo. We hypothesized that the increased cardiovascular observed psoriasis would be partially attributable elevated subclinical coronary artery burden composed noncalcified plaques high-risk features. However, inadequate efforts have been made directly measure this vulnerable population. As such, we sought compare total...
GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, disease associated with increased risk, provides a model to study biomarkers (CVD). Whether GlycA associates psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein is unknown.To investigate the relationships between CVD.Patients controls (n=412) participated 2-stage study. We measured by nuclear magnetic resonance spectroscopy. National...
Inflammation is critical in the development of atherosclerosis. Psoriasis a chronic inflammatory skin disease that associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography vivo and future cardiovascular events. It provides human model to understand effect treating target organ (eg, skin) on diseases.To investigate association between change severity at 1 year characterize impact anti-tumor necrosis factor therapy inflammation.In...
Background: Lipid-rich necrotic core (LRNC), a high-risk coronary plaque feature assessed by computed tomography angiography, is associated with increased risk of future cardiovascular events in patients subclinical, nonobstructive artery disease. Psoriasis chronic inflammatory condition that prevalence and events. This study characterized LRNC psoriasis how modulates response to biologic therapy. Methods: Consecutive naïve (n=209) underwent angiography at baseline 1-year assess changes...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
Inflammation is critical to atherosclerosis. Psoriasis, a chronic inflammatory disease associated with early cardiovascular events and increased aortic vascular inflammation (VI), provides model study the process of atherogenesis. Fludeoxyglucose F 18 positron emission tomography/computed tomography (18F-FDG PET/CT) helps quantify VI, coronary computed angiography artery (CAD) assessment through evaluation total plaque burden (TB) noncalcified (NCB), luminal stenosis, high-risk plaques...
Psoriasis is a systemic inflammatory skin disease associated with cardiovascular and lipid dysfunction. However, traditional parameters have limited prognostic value, whereas assessing oxidation-modified lipids in this driven condition may capture additional risk. Recently, study showed that psoriasis was increased lipid-rich coronary plaques; therefore, investigating potential relationships speed understanding of psoriasis.To understand whether associate phenotypes, cardiometabolic...
Inflammation is critical to atherogenesis. Psoriasis a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides compelling model understand potential pathways linking these diseases. A murine capturing the vascular metabolic diseases psoriasis would accelerate our understanding provide platform test emerging therapies. We aimed characterize new of inflammation (Rac1V12) from cardiovascular standpoint identify novel atherosclerotic signaling modulated...
Psoriasis is an inflammatory condition associated with metabolic and cardiovascular disease. Apremilast, a phosphodiesterase 4 inhibitor, commonly used for psoriasis can cause weight loss.To determine the association between apremilast aortic vascular inflammation as assessed by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT), cardiometabolic markers (primary outcomes at week 16), abdominal fat composition.A single-arm, open-label, interventional,...
BACKGROUNDPsoriasis is a chronic inflammatory skin disease associated with increased obesity, noncalcified coronary artery burden (NCB), and incident myocardial infarction. Here, we sought to assess the relationship among inflammation, visceral adipose tissue (VAT), NCB. Furthermore, evaluated whether improvement in VAT would be reduction NCB over time psoriasis.METHODSConsecutive psoriasis patients underwent CT angiography quantify abdominal calculate at baseline (n = 237), 1 year 176), 4...
Psoriasis, a chronic inflammatory skin disease associated with accelerated noncalcified coronary burden (NCB) by computed tomography angiography (CCTA), accelerates lipoprotein oxidation in the form of oxidized modified lipoproteins. A transmembrane scavenger receptor for these lipoproteins is lectinlike low-density receptor-1 (LOX-1), which has been reported to be artery disease. It unknown whether this psoriasis.To assess association between soluble LOX-1 (sLOX-1) and NCB psoriasis over...
Inflammation plays an important role in the development of cardiovascular disease (CVD). Patients with chronic inflammation diseases have high levels and early fatal myocardial infarction due to early, unstable coronary plaques. Cholesterol crystals (CC) play a key atherogenesis. However, underlying mechanisms endothelial cell (EC)-derived CC formation are not well understood inflammation.We utilized combination mouse psoriasis model (K14-Rac1V12 model) human patients study effect...