A5027818431- Atherosclerosis and Cardiovascular Diseases
- Psoriasis: Treatment and Pathogenesis
- Coronary Interventions and Diagnostics
- Cell Adhesion Molecules Research
- Aortic aneurysm repair treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Angiogenesis and VEGF in Cancer
- Esophageal and GI Pathology
- Gastroesophageal reflux and treatments
- Macrophage Migration Inhibitory Factor
- Vitamin D Research Studies
- Genetic factors in colorectal cancer
- Testicular diseases and treatments
- CAR-T cell therapy research
- Liver physiology and pathology
- Infectious Aortic and Vascular Conditions
- Blood Pressure and Hypertension Studies
- Immune cells in cancer
- Apelin-related biomedical research
- Body Contouring and Surgery
- Hepatocellular Carcinoma Treatment and Prognosis
- Biomarkers in Disease Mechanisms
- Lipoproteins and Cardiovascular Health
Indiana University – Purdue University Indianapolis
2024-2025
Indiana University School of Medicine
2024-2025
Beth Israel Deaconess Medical Center
2022-2024
Harvard University
2024
Center for Vascular Biology Research
2024
Beth Israel Deaconess Hospital
2023
American University of Beirut
2017-2022
American University of Beirut Medical Center
2019-2022
Florida Atlantic University
2022
National Heart Lung and Blood Institute
2015-2019
GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, disease associated with increased risk, provides a model to study biomarkers (CVD). Whether GlycA associates psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein is unknown.To investigate the relationships between CVD.Patients controls (n=412) participated 2-stage study. We measured by nuclear magnetic resonance spectroscopy. National...
Psoriasis is an inflammatory skin disease associated with increased cardiovascular risk and serves as a reliable model to study atherogenesis. Because neutrophils are implicated in atherosclerosis development, this reports that the interaction among low-density granulocytes, subset of neutrophils, platelets noncalcified coronary plaque burden assessed by computed tomography angiography. early atherosclerotic can lead fatal myocardial infarction, granulocyte-platelet may play crucial target...
Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and paired x lymph node metastasis may elucidate potential role of molecular targeted therapy advanced stages. BRAF NRAS PTC (n = 253) with corresponding metastatic 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 a p-value <0.05, concordance via kappa agreement. mutation frequency conventional (cPTC): 56.8%, microcarcinoma (PTMC):...
Hepatoid adenocarcinoma of the stomach (HAS) is a rare aggressive tumor with hepatocellular differentiation. HAS often produces alpha fetoprotein (AFP), and metastasizes to lymph nodes liver. Molecular studies revealed Her2 amplification overexpression, association p53 mutations, but no KRAS mutations. EGFR BRAF mutations have not yet been evaluated in hepatoid carcinoma so far. Hereby, we present case 41-year-old female patient high AFP level liver metastases. analysis overexpression by...
Colorectal cancer (CRC), one of the leading causes cancer-related deaths, presents with challenging features related to its diagnosis and management. The incidence CRC in adolescent young adult (AYA) population has increased over past couple decades despite decline overall occurrence general population. Signet ring cell carcinoma is rare histopathologic subtypes CRC; however, it more prevalent AYA patients than older adults unconventional histologic characteristics, a distinct clinical...
Solitary fibrous tumor (SFT) of the pleura is an uncommon that often discovered incidentally on a routine chest X-ray. We report case young female with large, sessile, hypervascularized SFT presenting cardiopulmonary shock to rural hospital limited therapeutic interventions. propose, in this report, unique multidisciplinary approach for management such critical patient and safe resection tumor.
Lymphoepithelioma-like carcinoma (LELC) of the breast is an extremely rare tumor type. Histologically, it mimics undifferentiated nasopharyngeal by demonstrating nests neoplastic epithelial cells in a background lymphoplasmacytic infiltrates. This paper reports 62-year-old female patient with 3 × 1.5 cm BI-RADS type IV mass diagnosed on excisional biopsy as LELC. The negative for estrogen and progesterone receptors did not overexpress HER2/neu. Routine tests clearance before surgery were...
CD30 is a member of the tumor necrosis factor family cell surface receptors normally expressed in lymphocytes, as well some lymphomas, but has been described other malignancies. Anaplastic lymphoma kinase (ALK) tyrosine receptor that belongs to insulin superfamily, and neural cells, detected several There conflicting data literature describes expression these breast cancer, aim this study test ALK cohort Middle Eastern patients with carcinoma.Cases invasive cancer from archives AUBMC were...
Partial 2/3 hepatectomy in mice is used research to study the liver's regenerative capacity and explore outcomes of liver resection a number disease models. In classical partial mice, two five lobes, namely left median lobes representing approximately 66% mass, are resected en bloc with an expected postoperative survival 100%. More aggressive hepatectomies technically more challenging hence, have seldom been mice. Our group has developed mouse model extended technique which three including...
Partial 2/3 hepatectomy in mice is used research to study the liver's regenerative capacity and explore outcomes of liver resection a number disease models. In classical partial mice, two five lobes, namely left median lobes representing approximately 66% mass, are resected en bloc with an expected postoperative survival 100%. More aggressive hepatectomies technically more challenging hence, have seldom been mice. Our group has developed mouse model extended technique which three including...
Abstract Bypass graft failure occurs in 20%–50% of coronary and lower extremity bypasses within the first‐year due to intimal hyperplasia (IH). TSP‐2 is a key regulatory protein that has been implicated development IH following vessel injury. In this study, we developed biodegradable CLICK‐chemistry gelatin‐based hydrogel achieve sustained perivascular delivery siRNA rat carotid arteries endothelial denudation At 21 days, application embedded hydrogels significantly downregulated gene...
Introduction: Psoriasis is a chronic inflammatory disorder of the skin affecting 2-4% population and associated with an increased risk cardiovascular events, specifically myocardial infarction. Methods: In large, ongoing prospective cohort study psoriasis diseases (NCT01778569), we studied consecutive sample (n=100) aimed to investigate potential role that S100A8/A9 may have in linking CV disease measured by FDG PET CT coronary CTA. Furthermore, conducted vitro experiments on human aortic...
Restricted accessAbstractFirst published online February 1, 2016Comorbid Depression or Anxiety is Associated with Aortic Vascular Inflammation and Coronary Heart Disease beyond Traditional Cardiovascular risk Factors in PsoriasisT Aberra, A Joshi, […], J Lerman, Rodante, Silverman, T Aridi, M Chen, Playford, N Mehta+6-6View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.23
Introduction: Recent studies suggest that hsCRP may inaccurately predict coronary heart disease (CHD) in patients with chronic inflammatory disorders. GlycA, a novel biomarker measured by nuclear magnetic resonance, was associated future cardiovascular events large cohort study. Whether GlycA predicts CHD beyond is unknown. Psoriasis (PSO), increased risk, provides clinical human model to assess the utility of as risk marker CHD. Hypothesis: We hypothesized would associate CHD, total (TB)...
Introduction: Psoriasis is a chronic inflammatory disorder associated with vascular inflammation (VI), measured by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT), and increased risk of MI. Coronary plaque composition coronary computed angiography (CCTA) predicts both CV outcomes. Patients psoriasis are more likely to suffer from comorbid depression anxiety. Whether these comorbidities may accelerate the development CVD in not well characterized....
Introduction: Inflammation is a risk factor for the initiation and progression of atherosclerosis. Psoriasis (PSO), chronic inflammatory skin disease, an emerging cardiovascular (CV) disease. Indeed PSO severity associated with increased vascular inflammation (VI) by 18-FDG PET/CT in vivo future CV risk. However, longitudinal impact changes on disease unknown. Hypothesis: We hypothesized that improvement would associate VI FDG PET/CT. Methods: Consecutively recruited patients (N=102)...