A5004459215- Psoriasis: Treatment and Pathogenesis
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Cardiovascular Function and Risk Factors
- Tryptophan and brain disorders
- Systemic Lupus Erythematosus Research
- Trypanosoma species research and implications
- Lipoproteins and Cardiovascular Health
- Health, psychology, and well-being
- Vitamin D Research Studies
- Stress Responses and Cortisol
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Valve Diseases and Treatments
- Rheumatoid Arthritis Research and Therapies
- Synthesis and Biological Evaluation
- Cardiac Health and Mental Health
- Infrared Thermography in Medicine
- Metabolomics and Mass Spectrometry Studies
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hepatitis C virus research
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Antioxidant Activity and Oxidative Stress
- Research on Leishmaniasis Studies
- Hemodynamic Monitoring and Therapy
MedStar Georgetown University Hospital
2022-2025
Georgetown University
2022-2025
MedStar Washington Hospital Center
2023-2024
Washington Hospital
2023
Clinical Research Institute
2019-2020
National Institutes of Health
2016-2019
National Heart Lung and Blood Institute
2016-2019
Allegheny General Hospital
2016-2018
Duke University
2018
Kaiser Permanente
2017
Background: Psoriasis, a chronic inflammatory disease associated with an accelerated risk of myocardial infarction, provides ideal human model to study atherogenesis in vivo. We hypothesized that the increased cardiovascular observed psoriasis would be partially attributable elevated subclinical coronary artery burden composed noncalcified plaques high-risk features. However, inadequate efforts have been made directly measure this vulnerable population. As such, we sought compare total...
GlycA, an emerging inflammatory biomarker, predicted cardiovascular events in population-based studies. Psoriasis, disease associated with increased risk, provides a model to study biomarkers (CVD). Whether GlycA associates psoriasis and how it predicts subclinical CVD beyond high-sensitivity C-reactive protein is unknown.To investigate the relationships between CVD.Patients controls (n=412) participated 2-stage study. We measured by nuclear magnetic resonance spectroscopy. National...
Inflammation is critical in the development of atherosclerosis. Psoriasis a chronic inflammatory skin disease that associated with increased vascular inflammation by 18fluorodeoxyglucose positron emission tomography/computed tomography vivo and future cardiovascular events. It provides human model to understand effect treating target organ (eg, skin) on diseases.To investigate association between change severity at 1 year characterize impact anti-tumor necrosis factor therapy inflammation.In...
•Averaging triglycerides (TGs) improves risk prediction over single measurements.•TGs are associated with increased cardiovascular risk, even in the "normal" range.•The association between TGs and events differs by sex. BackgroundElevated of disease (CVD), but best way to both measure assess TG-related remains unknown.ObjectiveThe objective study was evaluate CVD determine whether average a series TG measurements is more predictive than measurement.MethodsWe examined 15,792 participants,...
Inflammation is critical to atherosclerosis. Psoriasis, a chronic inflammatory disease associated with early cardiovascular events and increased aortic vascular inflammation (VI), provides model study the process of atherogenesis. Fludeoxyglucose F 18 positron emission tomography/computed tomography (18F-FDG PET/CT) helps quantify VI, coronary computed angiography artery (CAD) assessment through evaluation total plaque burden (TB) noncalcified (NCB), luminal stenosis, high-risk plaques...
ABSTRACT Objective This study evaluated the safety and efficacy of isoproterenol administration as an adjunct for achievement target heart rate (HR) during dobutamine stress echocardiography (DSE). Background In DSE, optimal accuracy is achieved when a HR 85% maximal predicted (MPHR) attained. Although rarely studied, intravenous has been used therapy to atropine increase chronotropic response pharmacologic testing. Methods We identified 5569 DSE studies which 264 received at MedStar...
Patients with Chagas cardiomyopathy carry a significant risk of reactivation after heart transplantation. Reactivation disease can lead to graft failure or systemic complications such as fulminant central nervous system and sepsis. As such, careful screening for seropositivity prior transplant is crucial preventing negative outcomes in the post-transplant setting. One challenge these patients variety laboratory tests available their differing sensitivities specificities. In this case report,...
Restricted accessAbstractFirst published online February 1, 2016Determinants of Vascular Inflammation by 18-Fluorodeoxyglucose Pet/Mri: Findings from the Psoriasis, Atherosclerosis and Cardiometabolic Disease InitiativeMT Kabbany, AA Joshi, […], M Ahlman, J Rodante, JB Lerman, T Aberra, Silverman, A Dahiya, DA Bluemke, MP Playford, NN Mehta+8-8View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.37
Restricted accessAbstractFirst published online February 1, 2016Improvement in Psoriasis skin Disease Severity is Associated with Reduction of Coronary Plaque BurdenJB Lerman, AA Joshi, […], J Rodante, T Aberra, MT Kabbany, TF Salahuddin, Q Ng, Silverman, MY Chen, and NN Mehta+7-7View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.34
Introduction: Psychological stress and depression are linked to increased cardiovascular (CV) events in the general population psoriasis (PSO), a chronic inflammatory disease that increases CV risk. 18-FDG-PET/CT enables quantification of metabolic activity amygdala, neural tissue critically involved pathobiology depression. In individuals without diseases, amygdalar (AmygAct) associates with greater vascular inflammation (VI) events. However, it is not known whether PSO maintains this...
Restricted accessAbstractFirst published online February 1, 2016Comorbid Depression or Anxiety is Associated with Aortic Vascular Inflammation and Coronary Heart Disease beyond Traditional Cardiovascular risk Factors in PsoriasisT Aberra, A Joshi, […], J Lerman, Rodante, Silverman, T Aridi, M Chen, Playford, N Mehta+6-6View all authors affiliationsVolume 64, Issue 3https://doi.org/10.1136/jim-2016-000080.23
Introduction: Recent studies suggest that hsCRP may inaccurately predict coronary heart disease (CHD) in patients with chronic inflammatory disorders. GlycA, a novel biomarker measured by nuclear magnetic resonance, was associated future cardiovascular events large cohort study. Whether GlycA predicts CHD beyond is unknown. Psoriasis (PSO), increased risk, provides clinical human model to assess the utility of as risk marker CHD. Hypothesis: We hypothesized would associate CHD, total (TB)...