A5101969559- Lung Cancer Treatments and Mutations
- Sarcoma Diagnosis and Treatment
- Testicular diseases and treatments
- Colorectal Cancer Treatments and Studies
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
- Bladder and Urothelial Cancer Treatments
- Advanced Breast Cancer Therapies
- Ovarian cancer diagnosis and treatment
- Cancer Treatment and Pharmacology
- Gastric Cancer Management and Outcomes
- Multiple and Secondary Primary Cancers
- Cancer Genomics and Diagnostics
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related Molecular Pathways
- Multiple Myeloma Research and Treatments
- Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Cancer Immunotherapy and Biomarkers
- Vascular Tumors and Angiosarcomas
- Oral health in cancer treatment
- Pancreatic and Hepatic Oncology Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
Hammoud Hospital University Medical Center
2014-2023
Saint Joseph University
2013-2022
Lebanese University
2013-2015
Lankenau Medical Center
2015
Hôtel-Dieu de France
2004-2009
Rafik Hariri University Hospital
2009
American University of Beirut Medical Center
2009
Centre Léon Bérard
1995-1997
Institut Gustave Roussy
1995-1997
Oral complications of cancer therapy, such as oral dryness, dysphagia, and taste alteration, are associated with a negative impact in the quality life patients. Few supportive care measures available for complications. This case series reveals effectiveness photobiomodulation (PBM) therapy when used specific protocol parameters, management related to therapy. Dysphagia was measured using functional outcome swallowing scale staging oropharyngeal dysphagia (FOSS). mucositis according National...
Concordance between mutations in the primary papillary thyroid carcinoma (PTC) and paired x lymph node metastasis may elucidate potential role of molecular targeted therapy advanced stages. BRAF NRAS PTC (n = 253) with corresponding metastatic 46) were analyzed utilizing StripAssays (ViennaLab Diagnostics). Statistical analysis was performed using (SPSS, Inc.), version 24.0 a p-value <0.05, concordance via kappa agreement. mutation frequency conventional (cPTC): 56.8%, microcarcinoma (PTMC):...
Multiple randomized studies have shown that combination of chemotherapy and immune checkpoint inhibitors (ICIs) leads to better response rates survival as compared alone in the advanced stage NSCLC. Data suggesting a benefit using ICIs neoadjuvant therapy patients with early NSCLC are emerging. Eligible subjects were treatment naïve IB, II, resectable IIIA Patients received three cycles four doses avelumab every 2 weeks. squamous cell cancer cisplatin or carboplatin on day 1 gemcitabine days...
BACKGROUND Approximately 30% of patients with metastatic germ cell tumors require salvage chemotherapy for recurrent or refractory disease after first-line treatment. The optimal regimen remains to be determined. METHODS Fifty-four who failed cured therapy, were treated a VIP/VeIP including cisplatin (20 mg/m2/d d1 d5), ifosfamide (1.2 gm/m2/d and either etoposide (75 d5) vinblastine (0.11 mg/kg/d d2) 5 consecutive days every 3 weeks. RESULTS A complete remission was observed in 24 (44%) at...
The search for innovative therapeutic agents in non-small cell lung cancer (NSCLC) has witnessed a swift evolution. number of targeted drugs that can improve patient outcomes with an acceptable safety profile is steadily increasing. In this review, we highlight current have already been approved or are under evaluation the treatment patients NSCLC, either monotherapy combined therapy both first- and second-line settings. Experience targeting vascular endothelial growth factor its receptor,...
Successful management of oral mucositis, dysgeusia and dryness was made with fivesessions photobiomodulation. The severity mucositis measured according to the World Health Organization scale for assessment mucositis. Dysgeusia testing performed International Standards (ISO). For or hyposalivation, quantity total resting stimulated saliva (Q-sal, mL/min) measured.Photobiomodulation parameters, applications, treatment protocol used were suggested by an international multidisciplinary panel...
Hepatoid adenocarcinoma of the stomach (HAS) is a rare aggressive tumor with hepatocellular differentiation. HAS often produces alpha fetoprotein (AFP), and metastasizes to lymph nodes liver. Molecular studies revealed Her2 amplification overexpression, association p53 mutations, but no KRAS mutations. EGFR BRAF mutations have not yet been evaluated in hepatoid carcinoma so far. Hereby, we present case 41-year-old female patient high AFP level liver metastases. analysis overexpression by...
Only drafts of regulatory guidelines for the registration biosimilars are available in Lebanon. We analyzed results a regional survey conducted Lebanon to understand impact different parameters on acceptance and future prescription biosimilars. also reviewed current situation around world. The study surveyed healthcare professionals from Arab countries, Iran, Belgium Italy. Data about participants' specialty, country residence, their knowledge biosimilars, biosimilars' prescription, price...
Abstract Background Pulmonary hypertension (PHTN) is increasingly recognized as a serious complication of sickle cell disease (SCD). Our objective was to determine the prevalence PHTN and identify factors associated with among children young adults SCD in Lebanon. Procedure From June 2004 2008, 90 patients were studied. Correlation TRV LDH, mean corpuscular volume (MCV), fetal hemoglobin (HbF), hydroxyurea use, G6PD deficiency performed. Transthoracic Doppler echocardiography performed...
JAK2 V617F mutation is gaining more acceptance in laboratory testing as part of the differential diagnosis work-up myeloproliferative disorders (MPD). This report first its kind from Lebanon that analyzes distribution this among a series referred cases to major tertiary referral center.Real-time polymerase chain reaction using MutaScreen assay (IPSOGEN Cancer Profiler) was performed on 229 patients.JAK2 found be positive 100% polycythemia vera cases, 68.29% essential thrombocythemia and...
To describe the 5-year experience of a multidisciplinary limb salvage program for children and adolescents with malignant bone tumors in Lebanon.Between January 2002 to February 2007, 30 (2 Ewing sarcoma 28 osteosarcoma) underwent Limb Salvage Surgeries (LSS) at American University Beirut Medical Center after partnering team St. Judes Children's Research Hospital (SJCRH). Procedures performed included 12 Repiphysis, noninvasively expandable, prostheses inserted skeletally immature children,...
Triple-negative breast cancer (TNBC) is characterized by its aggressive behavior, metastasis and lack of targeted therapies. Herein, we discuss the clinical, histopathological genetic profile a woman diagnosed with TNBC. Since patient had no durable response to chemotherapy, profiling was carried out. Next-generation sequencing analysis 592 genes showed missense mutation, p.E545A in PIK3CA, thus started on mTOR inhibitor everolimus, combination exemestane, which controlled her pain; however,...
Colorectal cancer (CRC), one of the leading causes cancer-related deaths, presents with challenging features related to its diagnosis and management. The incidence CRC in adolescent young adult (AYA) population has increased over past couple decades despite decline overall occurrence general population. Signet ring cell carcinoma is rare histopathologic subtypes CRC; however, it more prevalent AYA patients than older adults unconventional histologic characteristics, a distinct clinical...
CDK4/6 inhibitors in association with aromatase have led to a paradigm shift the management of metastatic positive hormone-receptors breast cancer. Liver toxicity is common these agents, but no data are reported on sequential use case confirmed efficacy and intolerable toxicity. In this article, we report successful Palbociclib cancer patient after initial response Ribociclib, which was interrupted for grade 4 liver