A5061605629- Congenital Heart Disease Studies
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Cardiac Valve Diseases and Treatments
- COVID-19 Clinical Research Studies
- Sphingolipid Metabolism and Signaling
- Cardiomyopathy and Myosin Studies
- Aortic Disease and Treatment Approaches
- Congenital heart defects research
- Lipoproteins and Cardiovascular Health
- Cardiovascular Conditions and Treatments
- Mechanical Circulatory Support Devices
- Pulmonary Hypertension Research and Treatments
- Cardiac tumors and thrombi
- SARS-CoV-2 and COVID-19 Research
- Neonatal Health and Biochemistry
- Cardiovascular Effects of Exercise
- Pericarditis and Cardiac Tamponade
- Congenital Anomalies and Fetal Surgery
- Streptococcal Infections and Treatments
- Kawasaki Disease and Coronary Complications
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tracheal and airway disorders
American University of Beirut Medical Center
2016-2025
American University of Beirut
2012-2024
Children's Specialty Group
2023
Texas Tech University
2021
Texas Tech University Health Sciences Center
2021
Waterbury Hospital
2021
The University of Texas Health Science Center at Houston
2021
Emory University
2021
University Radiology
2021
Harvard University
2015
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous (HeFH) more common than HoFH, women with HeFH are diagnosed later undertreated compared to men; it unknown whether these sex differences also apply HoFH.
Abstract The association between isolated congenital heart defects and consanguinity was examined in 759 Lebanese patients with different types of malformations. subjects were the Children's Cardiac Registry Center (CCRC) at American University Beirut Medical Center. proportion first‐cousin marriages among cardiac compared to that National Collaborative Perinatal Neonatal Network (NCPNN), after adjusting for subjects' geographic distribution, highest reported by NCPNN. In general, overall...
Autosomal recessive congenital ichthyosis (ARCI) is a heterogeneous group of hereditary skin disorder characterized by an aberrant cornification the epidermis. ARCI classified into total 11 subtypes (ARCI1-ARCI11) based on their causative genes or loci. Of these, gene for only ARCI7 has not been identified, while it was previously mapped chromosome 12p11.2-q13.1. In this study, we performed genetic analyses three Lebanese families with ARCI, and successfully determined linkage interval to...
Abstract NKX2-5 mutations are associated with different forms of congenital heart disease. Despite the knowledge gained from molecular and animal studies, genotype-phenotype correlations in humans limited by lack large cohorts incomplete assessment family members. We hypothesized that studying role inbred populations homogeneous genetic backgrounds high consanguinity rates such as Lebanon could help closing this gap. sequenced 188 index CHD cases (25 ASD). Five variants (three segregated...
Solute carrier family 22 member 5 ( SLC22A5 ) encodes a sodium‐dependent ion transporter responsible for shuffling carnitine across the plasma membrane. This process provides energy heart, among other organs allowing beta‐oxidation of fatty acids. Mutations in result primary deficiency PCD ), disorder that manifests with cardiac, skeletal, or metabolic symptoms. We hereby describe two novel mutations Lebanese families associated exclusively cardiac phenotype. The frequency and skeletal...
Tricuspid Atresia (TA) is a rare form of congenital heart disease (CHD) with usually poor prognosis in humans. It presents as complete absence the right atrio-ventricular connection secured normally by tricuspid valve. Defects valve are so far not associated any genetic locus, although mutations numerous genes were linked to multiple forms disease. In last decade, Knock-out mice have offered models for cardiologists and geneticists study causes One such model was Nfatc1−/− embryos which die...
Postnatal exposure to steroids has been associated with hypertrophic cardiomyopathy (HCM) in the newborn. Such an effect not described infants born mothers who received antenatal steroids. We report three newborns whose were treated betamethasone prenatally different doses, duration of time, and developed various degrees HCM diagnosed by echocardiography. There was no maternal evidence diabetes except for one infant mother had a normal fasting postprandial blood glucose prior steroid...
Abstract Background The aim of the study is to examine effect limited and prolonged hyperoxia on neonatal rat lung. This done by examining morphologic changes apoptosis, expression ceramide, an important mediator inflammatory mediators represented IL-1β 2 proto-oncogenes that appear modulate apoptosis (Bax Bcl-2). Methods Newborn rats were placed in chambers containing room air or oxygen above 90% for 7 days. sacrificed at 3, 14 days their lungs removed. Sections fixed, subjected TUNEL,...
Background Peripherally inserted central catheters (PICC) are frequently used in neonatal intensive care units (NICU) to assist premature and critically ill neonates. Massive pleural effusions, pericardial cardiac tamponade secondary PICC extremely uncommon but have potentially fatal consequences. Objective This study investigates the incidence of tamponade, large pleural, effusions peripherally a unit at tertiary center over 10-year period. It explores possible etiologies behind such...
Valvular heart disease frequently occurs as a consequence of premature atherosclerosis in individuals with familial hypercholesterolemia (FH). Studies have primarily focused on aortic valve calcification heterozygous FH, but there is paucity data the incidence valvular homozygous FH. We performed echocardiographic studies 33 relatively young patients (mean age: 26 years) FH LDL 447 mg/dL, 73% apheresis) to look for subclinical valvulopathy. Twenty-one had evidence valvulopathy or mitral...