A5000816028- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Cholesterol and Lipid Metabolism
- Clinical Nutrition and Gastroenterology
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Hormonal Regulation and Hypertension
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Dialysis and Renal Disease Management
- Atherosclerosis and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Metabolism and Genetic Disorders
- Antioxidant Activity and Oxidative Stress
- Systemic Lupus Erythematosus Research
- Lipid metabolism and disorders
- Nutrition and Health in Aging
- Antibiotics Pharmacokinetics and Efficacy
- Venous Thromboembolism Diagnosis and Management
- Adipokines, Inflammation, and Metabolic Diseases
- Central Venous Catheters and Hemodialysis
- Diabetes Treatment and Management
- Cardiovascular Disease and Adiposity
- Fatty Acid Research and Health
Charles University
2016-2025
University Hospital Hradec Králové
2015-2025
University of Hradec Králové
2007-2024
Czech Geological Survey
2006-2023
European Atherosclerosis Society
2021
Ocní klinika
2009-2013
University of Defence
2006-2007
College of the Redwoods
2007
Institute of Ismaili Studies
2007
Jan Evangelista Purkyně Military Medical Academy
2001
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous (HeFH) more common than HoFH, women with HeFH are diagnosed later undertreated compared to men; it unknown whether these sex differences also apply HoFH.
Abstract Background Antimicrobial lock therapy is recommended for preventing and treating catheter‐related bloodstream infections, but different solutions have uncertain efficacy. Methods Two locks, 1.35% taurolidine 4% ethylenediaminetetraacetic acid (EDTA), were tested on Staphylococcus epidermidis , aureus methicillin‐resistant S. Pseudomonas aeruginosa multidrug‐resistant P. vancomycin‐resistant Enterococcus faecium Klebsiella oxytoca (carbapenemase producing), K. pneumoniae...
Abstract Background: Omentin-1 is an anti-inflammatory adipokine produced preferentially by visceral adipose tissue. Plasma levels of omentin-1 are decreased in obesity and other insulin-resistant states. Insulin resistance contributes to the changes cholesterol synthesis absorption as well. The aim this study was characterise plasma obese patients with diabetes mellitus type 1 during weight reduction, elucidate relationship between metabolism omentin-1. Methods: were measured diabetics ( n...
Study of neurotransmitter role in food intake regulation a leptin signaling deficient model, such as the Zucker rat, would benefit understanding mechanisms human obesity, which resistance is common syndrome. We studied dopamine (DA) and serotonin (5-HT) concentrations vivo ventromedial nucleus (VMN) hypothalamus, they relate to eating after deprivation obese lean 9-week-old male rats. DA 5-HT were measured by HPLC via microdialysis before during refeeding 24-h food-deprived Before was...
Abstract Introduction: Toxic epidermal necrolysis (TEN) is a rare, life‐threatening disease with high mortality rate that linked to drug toxicity. There lack of data about the underlying pathophysiologic mechanisms and treatment options. The only widely accepted TEN withdrawal offending followed by supportive care. potential roles corticosteroids, intravenous immunoglobulin (IVIG) plasmapheresis (TPE) remain controversial. Aims: We present four patients severe (all >80% involvement body...
Because food intake is a function of meal number and size because gender-related hormones are involved in feeding regulation, we explored effects orchiectomy testosterone replacement on the relationship between changes resulting patterns adult male rats, randomized into sham-operation groups. A rat eater meter measured indexes for 1 wk before 2 after castration during 8 days replacement. Orchiectomy leads to an immediate change number-to-size relationship, 1) pattern feeding; 2) significant...
The appetite suppressing effect of tobacco products, via the main pharmacological agent nicotine, is a major reason for its usage both by woman and man. Food intake (FI) could be changed altering either meal size (MZ) or number (MN), which are regulated dependently in reciprocal manner. present study investigated systemic nicotine administration on rat feeding pattern. Because gender differences effects male female rats were studied. Alzet mini-osmotic pumps (Model 2001) automated eatometer...
Rheological conditions basically influence tissue perfusion, oxygen and nutrient supply, regeneration in its consequence the course of pathological processes, especially microcirculation partially even macrocirculation. Haemorheo