A5019688595- Education, Psychology, and Social Research
- Hormonal Regulation and Hypertension
- Electrolyte and hormonal disorders
- Advanced Database Systems and Queries
- Lipoproteins and Cardiovascular Health
- Cancer, Lipids, and Metabolism
- Bone Tissue Engineering Materials
- Proteoglycans and glycosaminoglycans research
- Adipose Tissue and Metabolism
- Semantic Web and Ontologies
- Studies on Chitinases and Chitosanases
- Folate and B Vitamins Research
- Digital Humanities and Scholarship
- Effects and risks of endocrine disrupting chemicals
- Adrenal and Paraganglionic Tumors
- Phytase and its Applications
- Botany and Plant Ecology Studies
- Blood Pressure and Hypertension Studies
- Advanced Data Storage Technologies
- Renal function and acid-base balance
- Protein Hydrolysis and Bioactive Peptides
- Values and Moral Education
- Carbohydrate Chemistry and Synthesis
- Nitric Oxide and Endothelin Effects
- Osteoarthritis Treatment and Mechanisms
Charles University
2010-2023
Czech Academy of Sciences, Institute of Macromolecular Chemistry
2021-2023
Na Homolce Hospital
2000-2018
College of Polytechnics Jihlava
2017
BioVendor (Czechia)
2017
Masaryk University
2017
Contipro (Czechia)
2008-2015
Czech Academy of Sciences
1997-2014
Czech Academy of Sciences, Institute of Microbiology
1989-2014
University of South Bohemia in České Budějovice
2013
Homozygous familial hypercholesterolemia (HoFH) is a rare genetic condition characterized by extremely increased low-density lipoprotein (LDL) cholesterol levels and premature atherosclerotic cardiovascular disease (ASCVD). Heterozygous (HeFH) more common than HoFH, women with HeFH are diagnosed later undertreated compared to men; it unknown whether these sex differences also apply HoFH.
Nanomaterials are promising in the development of innovative therapeutic options that include tissue and organ replacement, as well bone repair regeneration. The expansion new nanoscaled biomaterials is based on progress field nanotechnologies, material sciences, biomedicine. In recent decades, nanomaterial systems have bridged line between synthetic natural worlds, leading to emergence a science called design for biological applications. replicating properties providing unique functions...
Hintergrund Tinnitus zählt zu den gesundheitlichen Beeinträchtigungen mit häufiger psychiatrischer Komorbidität, zur Symptomerfassung stehen dennoch nur wenige Selbstbeurteilungsinstrumente in deutscher Sprache Verfügung. Methoden Die vorliegende Validierung des ins Deutsche übersetzten Handicap Inventory (THI) wurde an 74 Patienten chronischem durchgeführt. Als Referenzskala diente der Tinnitusfragebogen von Goebel u. Hiller. Ergebnisse und Diskussion Durchschnittliche Item-Trennschärfe...
Bone marrow is an important source of mesenchymal stem cells (MSCs), and a promising tool for cytotherapy. MSC utilization limited by low cell yields obtained under standard isolation protocols. Herein, used bone collection sets were evaluated as valuable MSCs. Adherent washed from the examined widely accepted criteria defining Significant numbers (median 9million per set in passage 1) with colony-forming activity high proliferative potential at seeding densities obtained. These positive...
This study aimed to develop polyvinyl alcohol (PVA) -based scaffold enriched with hyaluronic acid (HA) and hydroxyapatite (HAp) using physical crosslinking by freezing–thawing method. We accomplished biological evaluation of scaffolds, swelling degree, bioactivity assessment, hemolytic test. The results showed that all types scaffolds should be safe for use in the human body. culturing osteoblast-like cells MG-63 their proliferation better adhesion due presence HA confirmed depending on...
Skin exposure to ultraviolet (UV) light evokes a complex stress response in keratinocytes. Keratin filament organization provides structural stability and mechanical integrity of Involucrin is transglutaminase substrate protein contributing the formation insoluble cornified envelopes. However, more role for keratins involucrin has been proposed, including regulation cell response. The aim was evaluate modulations keratin 1, 10 expression HaCaT these cells UV-B radiation, effects on c-Jun...
Abstract Hyaluronan‐based tissue substitutes are promising materials in cartilage reconstruction surgery. Herein, the chondrogenesis of human mesenchymal stem cells (MSC) a hydrogel based on tyramine derivative hyaluronan crosslinked by hydrogen peroxidase (HA‐TA) was evaluated. Human MSC seeded scaffold were incubated standard chondrogenic medium and enriched with bone morphogenetic protein‐6 (BMP6). Cell viability, gene expression selected markers (collagen type II, aggrecan, SOX9,...
Bone tissue engineering tries to simulate natural behavior of hard tissues. This study aimed produce scaffolds based on polyvinyl alcohol (PVA) and hyaluronic acid (HA) with hydroxyapatite (HAp) incorporated in two different ways, by situ synthesis physical mixing pre-prepared HAp. In resulted calcium deficient form HAp lower crystallinity. The proliferation human osteoblast-like cells MG-63 proved be better the synthesized compared those physically mixed For PVA/HA/HAp ratio 3:1:2, there...
Obesity and physical inactivity had already reached epidemic, becoming one of the leading causes death disability worldwide. The objective this study was to investigate current level a nearly three decades' trend muscular fitness (MF) nutritional state Czech children.In 2013, cross-sectional epidemiological survey conducted in schoolchildren with examination anthropometric characteristics measured MF using UNIFIT test, which normative for categories given as results national monitoring data...
Radioimmunoassay of plasma arginine-vasopressin (AVP) in regularly dialyzed patients with chronic renal insufficiency revealed a parallel increase AVP and osmolality (POsm) before dialysis (4.16 +/- 0.36 pg/ml 312.6 1.80 mOsm/1) their declin to the normal range (1.93 0.27 292.0 1.27 during dialysis. Plasma correlated POsm after (r = 0.611 0.453, p less than 0.01 0.05 respectively). The was lower would correspond rise that recorded healthy subjects dehydration. Statistical correlation between...
An XML transformation, commonly specified in XSLT, is an important step during XML-based data migration. Since common XSLT processors always parse input into DOM-like structure, processing of large sets to be migrated represents a significant problem; all available memory can exhausted, the trans-formation takes unacceptable long time, or even fail. In this survey we explore current state-of-the-art transformation on and present performance comparison DOM-based as well streaming STX...