A5033238465- HIV, Drug Use, Sexual Risk
- HIV/AIDS Research and Interventions
- COVID-19 epidemiological studies
- Hepatitis C virus research
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Sex work and related issues
- Reproductive tract infections research
- Liver Disease Diagnosis and Treatment
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- COVID-19 Pandemic Impacts
- HIV/AIDS Impact and Responses
- Vaccine Coverage and Hesitancy
- Migration, Health and Trauma
- Herpesvirus Infections and Treatments
- Syphilis Diagnosis and Treatment
- Congenital Heart Disease Studies
- SARS-CoV-2 detection and testing
- Adolescent Sexual and Reproductive Health
- Pregnancy and preeclampsia studies
- Prenatal Screening and Diagnostics
- Gestational Diabetes Research and Management
- Iron Metabolism and Disorders
American University of Beirut
2007-2025
Weill Cornell Medical College in Qatar
2011-2021
London School of Hygiene & Tropical Medicine
2014-2018
Infectious Disease Consultants
2014
Cornell University
2011-2013
American University of Beirut Medical Center
2006-2010
Royal Victoria Hospital
1983
University of Ulster
1983
University College Hospital
1982
University College London
1982
This study aims to inform SARS-CoV-2 vaccine development/licensure/decision-making/implementation, using mathematical modeling, by determining key preferred product characteristics and associated population-level impacts of a eliciting long-term protection. A prophylactic with efficacy against acquisition (VES) ≥70% can eliminate the infection. VES <70% may still control infection if it reduces infectiousness or duration among those vaccinated who acquire infection, is supplemented...
Abstract The SARS-CoV-2 pandemic resulted in considerable morbidity and mortality as well severe economic societal disruptions. Despite scientific progress, true infection severity, factoring both diagnosed undiagnosed infections, remains poorly understood. This study aimed to estimate age-stratified overall rates based on analysis of extensive epidemiological data for the pervasive epidemic Qatar, a country where < 9% population are ≥ 50 years. We show that severity fatality demonstrate...
We aimed to estimate, albeit crudely and provisionally, national, regional, global proportions of respective populations that have been infected with SARS-CoV-2 in the first year after introduction this virus into human circulation, assess infection morbidity mortality rates, factoring both documented undocumented infections. The estimates were generated by applying mathematical models 159 countries territories. percentage world's population has as 31 December 2020 was estimated at 12.56%...
The independent effect of consanguinity on the prevalence congenital heart defects (CHDs), all and specific types, was investigated in newborns admitted to nine hospitals located Beirut, Lebanon members National Collaborative Perinatal Neonatal Network (NCPNN). Cases were 173 Intensive Care Units (NICU) participating during 3-year period from January 1, 2000 December 31, 2002 diagnosed their hospital stay as having one or more CHD. with chromosomal abnormalities excluded. than CHD assigned...
Current geographic spread of documented severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections shows heterogeneity. This study explores the role age in potentially driving differentials infection spread, epidemic potential, and rates disease severity mortality across countries. An age-stratified deterministic mathematical model that describes SARS-CoV-2 transmission dynamics was applied to 159 countries territories with a population ≥1 million. Assuming worst-case scenario...
Abstract Lebanon, a middle-income country with ongoing political turmoil, unstable economic situation, and fragmented under-resourced health system, hosts about one million Syrian refugees since 2011. While the is currently experiencing substantial COVID-19 epidemic spread, no outbreaks have been reported yet among refugees. However, testing of this population remains limited exposure levels are high given dire living conditions close interaction host community. Here, we use quantitative...
A novel coronavirus strain, severe acute respiratory syndrome 2 (SARS-CoV-2), emerged in China. This study aims to characterize key attributes of SARS-CoV-2 epidemiology as the infection An age-stratified mathematical model was constructed describe transmission dynamics and estimate age-specific differences biological susceptibility infection, age-assortativeness mixing, transition rate infectious contacts (and reproduction number R0) following introduction mass interventions. The estimated...
Abstract Introduction Emerging HIV epidemics have been documented among people who inject drugs (PWID) in the Middle East and North Africa (MENA). This study estimates incidence PWID due to sharing needles/syringes MENA. It also delineates injecting drug use role as a driver of epidemic population, impact interventions. Methods A mathematical model transmission was applied seven MENA countries with sufficient recent epidemiological data prevalence ≥1% PWID. Estimations incident and/or...
Abstract Background Several SARS-CoV-2 vaccine candidates are currently in the pipeline. This study aims to inform development, licensure, decision-making, and implementation by determining key preferred product characteristics associated population-level impact. Methods Vaccination impact was assessed at various efficacies using an age-structured mathematical model describing transmission disease progression, with application for China. Results A prophylactic efficacy against acquisition (...
Popliteal pterygium syndrome (PPS) is a rare autosomal dominant disorder, thought to occur with an incidence of approximately 1 in 300 000 live births. The main clinical manifestations are popliteal webbing, cleft lip, palate, lower lip pits, syndactyly, and genital nail anomalies. This report describes the features two families PPS one isolated case, showing range anomalies found both within between families. has some common Van der Woude (VWS), also inherited as condition, lip/palate and,...
Background: Postpartum hemorrhage (PPH) is a leading cause of maternal morbidity and mortality, particularly in cesarean deliveries where uterine atony remains significant risk factor. Effective prophylactic interventions are essential to reduce excessive blood loss improve outcomes. Misoprostol, prostaglandin E1 analogue, widely used for PPH prevention due its potent uterotonic properties, cost-effectiveness, stability. However, the optimal route administration subject debate, sections...