A5073763153- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- T-cell and B-cell Immunology
- Asthma and respiratory diseases
- Skin and Cellular Biology Research
- Psoriasis: Treatment and Pathogenesis
- Contact Dermatitis and Allergies
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Skin Protection and Aging
- PI3K/AKT/mTOR signaling in cancer
- Nail Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Wnt/β-catenin signaling in development and cancer
- Cancer-related molecular mechanisms research
- Cutaneous lymphoproliferative disorders research
- Urticaria and Related Conditions
- RNA Research and Splicing
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Plant Reproductive Biology
- Single-cell and spatial transcriptomics
- Medication Adherence and Compliance
- Axon Guidance and Neuronal Signaling
- Research, Science, and Academia
Stanford University
2014-2025
Levanger Hospital
2019
Karolinska Institutet
1988-2016
Karolinska University Hospital
2011-2015
Center for Molecular Medicine and Immunology
2013
BACKGROUND. Alopecia areata (AA) is an autoimmune disease characterized by hair loss mediated CD8+ T cells. There are no reliably effective therapies for AA. Based on recent developments in the understanding of pathomechanism AA, JAK inhibitors appear to be a therapeutic option; however, their efficacy treatment AA has not been systematically examined.
Filaggrin is a key protein involved in maintaining skin barrier function and hydration. Mutations the filaggrin gene (FLG) cause ichthyosis vulgaris (IV) are major predisposing factor for atopic dermatitis (AD) individuals of European Asian descent. It has been proposed that FLG mutations population specific difference spectra between different ancestral groups described. However, it unknown whether African causative genetic IV predispose to AD, or other mechanisms more prominent.The present...
Background Several common genetic and environmental disease mechanisms are important for the pathophysiology behind atopic dermatitis (AD). Filaggrin (FLG) loss-of-function is of great significance barrier impairment in AD ichthyosis vulgaris (IV), which commonly associated with AD. The molecular background is, however, complex various clusters genes altered, including inflammatory epidermal-differentiation genes. Objective objective was to study whether functional alterations IV skin depend...
Interactions between the epidermis and immune system govern epidermal tissue homeostasis. These epidermis-immune interactions are altered in inflammatory disease psoriasis; however, pathways that underlie this aberrant response not well understood. Here, we determined Ras-related C3 botulinum toxin substrate 1 (RAC1) is a key mediator of dysfunction. RAC1 activation was consistently elevated psoriatic primary human keratinocytes (PHKCs) exposed to psoriasis-related stimuli, but skin from...
Inflammation is critical to atherogenesis. Psoriasis a chronic inflammatory skin disease that accelerates atherosclerosis in humans and provides compelling model understand potential pathways linking these diseases. A murine capturing the vascular metabolic diseases psoriasis would accelerate our understanding provide platform test emerging therapies. We aimed characterize new of inflammation (Rac1V12) from cardiovascular standpoint identify novel atherosclerotic signaling modulated...
Compelling evidence suggests that transplantation of neural stem cells (NSCs) from multiple sources ameliorates motor deficits after stroke. However, it is currently unknown to what extent the electrophysiological activity grafted NSC progeny participates in improvement and whether excitatory phenotypes are beneficial or deleterious sensorimotor performances. To address this question, we used optogenetic tools drive outputs NSCs assess impact on local circuitry performance. We genetically...
Epidemiological studies suggest that allergy risk is preferentially transmitted through mothers. This can be due to genomic imprinting, where the phenotype effect of an allele depends on its parental origin, or maternal effects reflecting genome's influence child during prenatal development. Loss-of-function mutations in filaggrin gene (FLG) cause skin barrier deficiency and strongly predispose atopic dermatitis (AD). We investigated 4 most prevalent European FLG (c.2282del4, p.R501X,...
The strong association between epidermal barrier gene variants and Atopic Dermatitis (AD) highlights that impaired skin is a key feature in the pathogenesis of AD. Although filaggrin (FLG) major AD risk European Asian populations, disease-associated remain elusive African populations.A previous study has reported tight junction CLDN1 have been associated with susceptibility disease severity African-Americans. Our aim was therefore to investigate Ethiopian population.To how may be involved...
X-linked recessive ichthyosis (XLRI) is due to deletions or inactivating mutations in the steroid sulfatase (STS) gene. This results an accumulation of cholesterol sulphate affecting packing intercorneocyte lipids. XLRI characterized by dry, scaly skin and increased barrier permeability; patients are often dependent on daily use moisturizers.To examine biophysical molecular changes with compared healthy volunteers, analyse effects moisturizers patients' function.Patients (n=14) controls were...
Abstract Background Loss‐of‐function mutations in FLG (encoding filaggrin) are a predisposing factor for atopic dermatitis ( AD ) and cause ichthyosis vulgaris IV ). Patients with display impaired skin barrier dry skin, altered epidermal expression of genes pro‐inflammatory lipid metabolic pathways often evident. Objectives To evaluate the effect three different moisturizers on function gene patients / relation to mutation status. Methods n = 43) were classified according their status: +/+...
ABSTRACT Chicken erythrocyte histone H5 has been suggested repeatedly to be a general suppressor of transcription and replication. Therefore, the biological functions were investigated compared with those Hl (Hla + Hlb) by microinjection purified proteins into proliferating L6 rat myoblasts. By pulse-labelling injected cells [3H] uridine thymidine it was shown that blocked both replication substantially, chromatin became densely compacted. also suppressed these functions, but much lesser...
Inflammatory skin disease is characterized by a pathologic interplay between cells and immunocytes can result in disfiguring cutaneous lesions systemic inflammation. Immunosuppression commonly used to target the inflammatory component; however, these drugs are often expensive associated with side effects. To identify previously unidentified targets, we carried out nonbiased informatics screen drug compounds an inverse transcriptional signature keratinocyte signals. Using psoriasis,...
Background Atopic dermatitis (AD) is a common chronic inflammatory skin disorder where epidermal barrier dysfunction major factor in the pathogenesis. The identification of AD susceptibility genes related to therefore importance. transglutaminases (TGM1, TGM3 and TGM5) encodes essential cross-linking enzymes epidermis. Objective To determine whether genetic variability contributes susceptibility. Methods Forty-seven single nucleotide polymorphisms (SNPs) TGM1, TGM5 gene region were tested...
Abstract Genetic variants in filaggrin ( FLG ) involving truncating mutations or intragenic copy number variation are strongly associated with the risk of developing atopic dermatitis (AD) European and Asian populations. Few loss‐of‐function have been identified Africans, although an association between AD severity a small African American cohort has proposed. We studied 132 Ethiopians found no number, suggesting that other, still unidentified genetic factors more importance predisposing to .
Abstract Background Atopic dermatitis (AD; OMIM#603165) and psoriasis (OMIM#177900) are two common inflammatory skin disorders. Both genetically complex, multifactorial do not follow a Mendelian pattern of inheritance. diseases share several genetic susceptibility loci such as the epidermal differentiation complex ( EDC ) on chromosome 1q21. Within , mutations in filaggrin FLG gene strongly associated with AD whereas no association has been replicated psoriasis. However, reduced levels have...