A5008134033- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Digital Radiography and Breast Imaging
- AI in cancer detection
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- BRCA gene mutations in cancer
- Dementia and Cognitive Impairment Research
- Economic and Financial Impacts of Cancer
- Advanced Causal Inference Techniques
- Statistical Methods in Clinical Trials
- Radiomics and Machine Learning in Medical Imaging
- Health Systems, Economic Evaluations, Quality of Life
- Statistical Methods and Inference
- Health disparities and outcomes
- Machine Learning in Healthcare
- Bladder and Urothelial Cancer Treatments
- Chemotherapy-induced cardiotoxicity and mitigation
- Healthcare Policy and Management
- Artificial Intelligence in Healthcare
- Chronic Disease Management Strategies
- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
Kaiser Permanente Washington Health Research Institute
2010-2025
Dartmouth Institute for Health Policy and Clinical Practice
2014-2025
University of Washington
2008-2025
University of California, Davis
2012-2025
Fred Hutch Cancer Center
2011-2025
Huntsman Cancer Institute
2025
University of Vermont
2012-2025
Dartmouth College
2025
University of Illinois Chicago
2025
Brown University
2024-2025
Many medications have anticholinergic effects.In general, anticholinergicinduced cognitive impairment is considered reversible on discontinuation of therapy.However, a few studies suggest that anticholinergics may be associated with an increased risk for dementia.OBJECTIVE To examine whether cumulative use higher incident dementia. DESIGN, SETTING, AND PARTICIPANTSProspective population-based cohort study using data from the Adult Changes in Thought Group Health, integrated health care...
Background: False-positive mammography results are common. Biennial screening may decrease the cumulative probability of false-positive across many years repeated but could also delay cancer diagnosis. Objective: To compare and stage distribution incident breast after 10 annual or biennial mammography. Design: Prospective cohort study. Setting: 7 registries in National Cancer Institute–funded Breast Surveillance Consortium. Participants: 169 456 women who underwent first at age 40 to 59...
<b>Objective</b> To determine whether higher cumulative use of benzodiazepines is associated with a risk dementia or more rapid cognitive decline. <b>Design</b> Prospective population based cohort. <b>Setting</b> Integrated healthcare delivery system, Seattle, Washington. <b>Participants</b> 3434 participants aged ≥65 without at study entry. There were two rounds recruitment (1994-96 and 2000-03) followed by continuous enrollment beginning in 2004. <b>Main outcomes...
Controversy exists about the frequency women should undergo screening mammography and whether interval vary according to risk factors beyond age.To compare benefits harms of frequencies age, breast density, postmenopausal hormone therapy (HT) use.Prospective cohort.Data collected January 1994 December 2008 from facilities in community practice that participate Breast Cancer Surveillance Consortium (BCSC) registries.Data were prospectively on 11,474 with cancer 922,624 without who underwent...
We sought to examine whether frailty is associated with dementia, Alzheimer's disease (AD), and non-AD dementia risk. This a prospective population-based cohort derived from an integrated health maintenance organization. The sample consisted of 2,619 participants aged 65 older without at baseline followed 1994 2010. Frailty was defined as having least 3 the following criteria: weakness (grip strength), slowness (walking speed), weight loss, low physical activity, self-reported exhaustion....
We estimated dementia incidence rates, life expectancies with and without dementia, percentage of total expectancy dementia.We studied 3605 members Group Health (Seattle, WA) aged 65 years or older who did not have at enrollment to the Adult Changes in Thought study between 1994 2008. rates Alzheimer's disease as well defined average number one is expected live dementia.Dementia increased through ages 85 89 (74.2 cases per 1000 person-years) 90 (105 person-years). Life decreased age. was...
Background: Estimates of risk for radiation-induced breast cancer from mammography screening have not considered variation in dose exposure or diagnostic work-up after abnormal results. Objective: To estimate distributions incidence and mortality digital while considering among women. Design: 2 simulation-modeling approaches. Setting: U.S. population. Patients: Women aged 40 to 74 years. Intervention: Annual biennial age 40, 45, 50 years until Measurements: Lifetime deaths averted (benefits)...
Whether co-occurring neuropathologies interact or independently affect clinical disease progression is uncertain. We estimated rates of and tested whether associations between Alzheimer's neuropathology (ADNP) were modified by Lewy body (LBD) vascular brain injury (VBI).Linear mixed effects models evaluated longitudinal trends in the Clinical Dementia Rating Scale Sum Boxes on 2046 autopsied participants seen at a U.S. Disease Center.Annual was slightly faster for ADNP + LBD compared with...
Compared with film, digital mammography has superior sensitivity but lower specificity for women aged 40 to 49 years and dense breasts. Digital replaced film in virtually all US facilities, overall population health cost from use of this technology are unclear. Using five independent models, we compared screening strategies starting at age or 50 applied annually, biennially, based on density biennial ages 74 no screening. Common data elements included cancer incidence test performance, both...
Background We examined the longitudinal associations between changes in cardiovascular biomarkers and cancer therapy–related cardiac dysfunction ( CTRCD ) patients with breast treated cardotoxic therapy. Methods Results Repeated measures of high‐sensitivity troponin T (hs‐ cTnT ), NT ‐pro BNP (N‐terminal pro‐B‐type natriuretic peptide), myeloperoxidase, placental growth factor, differentiation factor 15 were assessed longitudinally a prospective cohort 323 anthracyclines and/or trastuzumab...
Background: Psoriasis is a chronic inflammatory disease associated with dyslipidemia, cardiovascular events, and mortality. We aimed to assess compare the effect of treatment moderate-to-severe psoriasis adalimumab or phototherapy on vascular inflammation biomarkers. Methods Results: Randomized, double-blind, trial adalimumab, phototherapy, placebo (1:1:1) for 12 weeks, crossover 52 weeks total. Outcomes included by 18 F-fluorodeoxyglucose positron emission tomography/computed tomography...
Patients with cirrhosis are at increased risk of postoperative mortality. Currently available tools to predict suboptimally calibrated and do not account for surgery type. Our objective was use population-level data derive internally validate surgical models.
<h3>Importance</h3> Transportation barriers contribute to missed primary care appointments for patients with Medicaid. Rideshare services have been proposed as alternatives nonemergency medical transportation programs because of convenience and lower costs. <h3>Objective</h3> To evaluate the association between rideshare-based among Medicaid patients. <h3>Design, Setting, Participants</h3> In a prospective clinical trial, 786 beneficiaries who resided in West Philadelphia were established at...
Objectives To determine whether prescription opioid use is associated with higher dementia risk or greater cognitive decline. Design Prospective cohort study. Setting Group Health, an integrated healthcare delivery system. Participants Community‐dwelling individuals aged 65 and older without at least 10 years of Health enrollment baseline (N = 3,434; median age 74). Measurements The Cognitive Abilities Screening Instrument (CASI) was administered every 2 years. Low scores triggered detailed...
Background Limited data exist beyond prevalence rounds of digital breast tomosynthesis (DBT) screening. Purpose To compare DBT outcomes over multiple years and to mammography (DM) Materials Methods Retrospective analysis included 1 year DM 5 screening (September 2011 September 2016); 67 350 examinations were performed in 29 310 women. Recall rate (RR) percentage, cancer detection (CDR) per 1000 women screened, false-negative positive predictive value recall (PPV1) biopsies sensitivity,...
Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a spectrum of severe mucocutaneous drug reaction associated with significant morbidity and mortality. A previously developed SJS/TEN-specific severity-of-illness model (Score Toxic Epidermal Necrolysis [SCORTEN]) has been reported to overestimate underestimate SJS/TEN-related in-hospital mortality in various populations.To derive risk prediction for among patients SJS/TEN compare prognostic accuracy the SCORTEN...
The coronavirus disease-2019 (COVID-19) pandemic has caused abrupt shifts in US health care delivery.1Murthy S. et al.JAMA. 2020; 323: 1499-1500Crossref PubMed Scopus (530) Google Scholar To preserve inpatient resources and minimize COVID-19 transmission, many systems have expanded telemedicine, limited hospital transfers, established stringent hospitalization criteria for non–COVID-19-related conditions. States also enacted, on varying timelines, shelter-in-place (SIP) or equivalent orders...
<h3>Importance</h3> Cardiovascular disease is a leading cause of mortality in patients with prostate cancer, and androgen deprivation therapy (ADT) may worsen cardiovascular risk. Adherence to guideline-recommended assessment management risk factors (CVRFs) initiating ADT unknown. <h3>Objective</h3> To describe CVRF men cancer overall. <h3>Design, Setting, Participants</h3> A cross-sectional analysis 90 494 treated within the US Veterans Health Administration diagnosed between January 1,...
The electronic health record (EHR) has become increasingly ubiquitous. At the same time, professionals have been turning to this resource for access data that is needed delivery of care and clinical research. There little doubt EHR made both these functions easier than earlier days when we relied on paper-based records. Coupled with modern database warehouse systems, high-speed networks, ability share others are large number challenges arguably limit optimal use OBJECTIVES: Our goal was...
Importance The incidence of arterial thromboembolism and venous in persons with COVID-19 remains unclear. Objective To measure the 90-day risk patients hospitalized before or during vaccine availability vs influenza. Design, Setting, Participants Retrospective cohort study 41 443 (April-November 2020), 44 194 (December 2020-May 2021), 8269 influenza (October 2018-April 2019) US Food Drug Administration Sentinel System (data from 2 national health insurers 4 regional integrated systems)....
Breast cancer screening with digital breast tomosynthesis may decrease false-positive results compared mammography.To estimate the probability of receiving at least 1 result after 10 years vs mammography in US.An observational comparative effectiveness study data collected prospectively for examinations was performed between January 1, 2005, and December 31, 2018, 126 radiology facilities Cancer Surveillance Consortium. Analysis included 903 495 individuals aged 40 to 79 years. Data analysis...
Importance Guidelines recommend shared decision-making prior to initiating lung cancer screening (LCS). However, evidence is lacking on how best implement in clinical practice. Objective To evaluate the impact of an LCS Decision Tool (LCSDecTool) quality and uptake. Design, Setting, Participants This randomized trial enrolled participants at Veteran Affairs Medical Centers Philadelphia, Pennsylvania; Milwaukee, Wisconsin; West Haven, Connecticut, from March 18, 2019, September 29, 2021, with...