A5081360658- Cardiovascular Health and Risk Factors
- Mobile Health and mHealth Applications
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Stress Responses and Cortisol
- Urban Transport and Accessibility
- Nutritional Studies and Diet
- Tryptophan and brain disorders
- Cardiovascular Disease and Adiposity
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Health disparities and outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Atherosclerosis and Cardiovascular Diseases
- Adipose Tissue and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Hormonal Regulation and Hypertension
- Appendicitis Diagnosis and Management
- Cardiac Health and Mental Health
- Sperm and Testicular Function
- Diagnosis and Treatment of Venous Diseases
- Impact of Technology on Adolescents
- Food Security and Health in Diverse Populations
- Birth, Development, and Health
- Minimally Invasive Surgical Techniques
National Heart Lung and Blood Institute
2016-2024
National Institutes of Health
2016-2024
Office of Extramural Research
2022
Vanderbilt University
2011
Cornell University
2010
University of Córdoba
2010
Université de Lille
2008
Centre Hospitalier Universitaire de Lille
2006-2008
Hôpital Albert Calmette
2004-2008
Hôpital de la Conception
2006
Little is known about the spatial clustering of neighborhood deprivation across United States (US). Using data from 2010 US Census Bureau, we created a index (NDI: higher NDI indicates deprivation/ lower socioeconomic status) for each county within County level scores were loaded into ArcGIS 10.5.1 where they mapped and analyzed using Moran's I Anselin Local I. Ultimately, varies spatially US. The highest found in Southeastern Southwestern states, inland regions Southern California. This...
Wearable mobile health (mHealth) technologies offer approaches for targeting physical activity (PA) in resource-limited, community-based interventions. We sought to explore user characteristics of PA tracking, wearable technology among a population within and needs assessment. In 2014–2015, we conducted the Washington, D.C., Cardiovascular Health Needs Assessment predominantly African-American churches communities with higher obesity rates lower household incomes. Participants received...
Chronic stress is associated with cardiovascular disease (CVD) risk and elevated amygdala activity. Previous research suggests a plausible connection between activity, hematopoietic tissue events; however, the underlying biological mechanisms linking these relationships are incompletely understood. thought to modulate epigenomic modifications. Our investigation focused on associations activity (left (L), right (R), maximum (M), average (Av) AmygA), splenic (SpleenA), bone marrow (BMA) as...
Background: Resource-limited communities in Washington, D.C. have high rates of obesity-related cardiovascular disease addition to inadequate physical activity (PA) facilities and limited Internet access. Engaging community members the design implementation studies address these health disparities is essential success community-based PA interventions. Objective: The objective study was use qualitative quantitative methods evaluate feasibility acceptability PA-monitoring wristbands Web-based...
Community-based participatory research is an effective tool for improving health outcomes in minority communities. Few community-based studies have evaluated methods of optimizing smartphone apps technology-enabled interventions African Americans.This study aimed to utilize focus groups (FGs) gathering qualitative data inform the development app that promotes physical activity (PA) among American women Washington, DC.We recruited a convenience sample (N=16, age range 51-74 years) from...
Little is known about recruitment methods for racial/ethnic minority populations from resource-limited areas community-based health and needs assessments, particularly assessments that incorporate mobile (mHealth) technology characterizing physical activity dietary intake. We examined whether the Communication, Awareness, Relationships Empowerment (C.A.R.E.) model could reduce challenges recruiting retaining participants faith-based organizations in predominantly African American Washington,...
Despite the widespread prevalence of cases associated with coronavirus disease 2019 (COVID-19) pandemic, little is known about spatial clustering COVID-19 in United States. Data on were used to identify U.S. counties that have both high and low incident proportions clusters. Our results suggest there are a variety sociodemographic variables severity county-level proportions. As pandemic evolved, communities color disproportionately impacted. Subsequently, it shifted from metropolitan areas...
Introduction A mixed-method, co-design approach to studying the adoption of mobile health (mHealth) technology among African-American (AA) women has not been fully explored. Qualitative data may contextualise existing knowledge surrounding perceptions mHealth AA as part formative work for designing a physical activity application (app). Methods convenience sample 16 completed an informatics survey prior participating in focus groups exploring their use and apps. Survey responses provided...
Background: Psychosocial stress correlates with cardiovascular (CV) events; however, associations between physiologic measures of stressors and CVD remain incompletely understood, especially in racial/ethnic minority populations resource-limited neighborhoods. We examined chronic stress-related neural activity, measured by amygdalar 18 Fluorodeoxyglucose ( FDG) uptake, aortic vascular FDG uptake (arterial inflammation measure) a community-based cohort. Methods: Forty participants from the...
Optimization of existing measurement tools is necessary to explore links between aspects the neighborhood built environment and health behaviors or outcomes. We evaluate a scoring method for virtual audits utilizing Active Neighborhood Checklist (the Checklist), audit measure, assess street segment representativeness in low-income neighborhoods. Eighty-two home neighborhoods Washington, D.C. Cardiovascular Health/Needs Assessment (NCT01927783) participants were audited using Google Street...
Objectives Little is understood about associations between neighborhood characteristics and depression, a cardiovascular disease (CVD) risk factor, in diverse populations. We examined relationships perceived/objective characteristics, CVD markers within the Washington, DC CV Health/Needs Assessment, an evaluation among predominantly African-American (AA) adults resource-limited communities.Method Factor analysis of overall environment perception (NEP) identified three NEP sub-scores:1)...
Neighborhoods and the microbiome are linked to cardiovascular disease (CVD), yet investigations identify microbiome-related factors at neighborhood levels have not been widely investigated. We sought explore relationships between deprivation index (NDI) microbial metabolite, trimethylamine-N-oxide. hypothesized that inflammatory markers dietary intake would be mediators of relationship.
Familial male-limited precocious puberty is a dominant autosomal genetic disease caused by activating LH receptor gene mutations, clinically expressed only in males. In preliminary studies, addition to the expected testosterone increase, we found high inhibin B levels before age of normal puberty.The objective study was assess cellular origin serum thanks testis section immunostaining.Serum testosterone, gonadotropin, B, pan-alphaC-inhibin, and anti-Mullerian hormone were measured....
Abstract Background Cardiovascular disease (CVD) is the leading cause of death in world. Given role immune cells atherosclerosis development and progression, effective methods for characterizing cell populations are needed, particularly among disproportionately at risk CVD. Results By using a variety antibodies combined one staining protocol, we were able to identify granulocyte, lymphocyte, monocyte sub-populations by CD-antigen expression from 500 µl whole blood, enabling more extensive...
A pressing need exists to understand and optimize the use of dietary assessment tools that can be used in community-based participatory research (CBPR) interventions. digital food record, which uses a mobile device capture intake through text photography inputs, is particularly promising method. However, little understood about acceptability feasibility records CBPR how best tailor needs community.
There is no established method for processing data from commercially available physical activity trackers. This study aims to develop a standardized approach defining valid wear time use in future interventions and analyses. Sixteen African American women (mean age = 62.1 years mean body mass index 35.5 kg/m2) wore the Fitbit Charge 2 20 days. Method 1 defined day as ≥10-hr with heart rate data. removed minutes without data, ≤ - SDs below ≤2 steps, nighttime. Linear regression modeled steps...
Context McCune–Albright syndrome (MAS) is a disorder caused by post-zygotic gain-of-function mutation in the gene encoding Gs-α protein. Sexual precocity, common girls, has been reported only 15% of boys, and little known on long-term evolution MAS males. Objective In boy with MAS, we studied spermatogenesis, testis histology, immunohistochemistry aim to shed light seminiferous tubule activity. Design A who presented at age 2.9 years sexual monolateral macroorchidism, increased testosterone...
Background: Cooking is an identified dietary strategy that positively associated with optimal diet quality. Prior to initiating cooking interventions, evaluating the prospective acceptability of intervention among community members living within low food access areas and understanding geospatial shopping locations may aid in designing community-tailored interventions. Methods: A sequential mixed methods study was conducted determine a planned community-located African American adults area at...
Neighborhood socioeconomic deprivation is associated with increased cardiovascular risk factors, including inflammation. Inflammation plays an important role in modifying the cardioprotective function of high-density lipoprotein (HDL). Moreover, recent studies suggest that very high HDL adverse disease (CVD) outcomes. Thus, we sought to explore relationships between neighborhood as a marker chronic stress, inflammation, proprotein convertase subtilisin/kexin type 9 (PCSK9) (a core component...
We have investigated the physiological role of marked increase in plasma epinephrine that occurs fasted exercising rats. Fasted adrenodemedullated (ADM) rats show a reduction endurance run times compared with sham-operated (SO) controls. After running for 30 min at 21 m/min up 10% grade, ADM rats' blood glucose was 2.9 +/- 0.1 mM vs. 4.3 0.2 SO At same time, lactate 3.0 1.0 Glycogenolysis impaired fast-twitch white region quadriceps, lateral gastrocnemius, and soleus muscles but not red...
Introduction Although physical activity (PA) reduces cardiovascular disease (CVD) risk, inactivity remains a pressing public health concern, especially among African American (AA) women in the USA. PA interventions focused on AA living resource-limited communities with scarce infrastructure are needed. Mobile (mHealth) technology can increase access to interventions. We describe development of clinical protocol for multilevel, community-based, mHealth intervention women. Methods and analysis...
Sedentary time (ST) and neighborhood environment (NE) are predictors of cardiovascular (CV) health. However, little is known about ST's relationship with NE. We examined associations perceived objective NE ST in the predominantly African American faith-based population Washington, D.C. CV Health Needs Assessment. After using community-based research principles, participants reported perceptions, including sidewalks, recreational areas, crime presence. Factor analysis was conducted to explore...
Identifying mechanisms to maintain CBPR studies during an infectious disease pandemic is vital. The current paper describes the changes in methods and processes conducted within a mixed-methods study virtual setting novel coronavirus (COVID-19) pandemic.The DC Community Organizing for Optimal Culinary Knowledge with Heart (DC COOKS Heart) was designed assess feasibility of dietary behavior intervention among African-American adults that are at risk cardiovascular (CVD). under umbrella...