A5084468302- Regulation of Appetite and Obesity
- Adipokines, Inflammation, and Metabolic Diseases
- Adipose Tissue and Metabolism
- Hypothalamic control of reproductive hormones
- Obesity, Physical Activity, Diet
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Growth Hormone and Insulin-like Growth Factors
- Biochemical Analysis and Sensing Techniques
- Plant Reproductive Biology
- Birth, Development, and Health
- Health and Lifestyle Studies
- Child Nutrition and Feeding Issues
- Hormonal and reproductive studies
- Autism Spectrum Disorder Research
- Ovarian function and disorders
- Child Development and Digital Technology
- Sexual Differentiation and Disorders
- Vitamin D Research Studies
- Sleep and related disorders
- Glycogen Storage Diseases and Myoclonus
- Diet and metabolism studies
- Magnetic and Electromagnetic Effects
- Nuclear Structure and Function
- Diabetes and associated disorders
- Genetics and Neurodevelopmental Disorders
Universidad Autónoma de Madrid
2016-2025
Hospital Universitario Fundación Jiménez Díaz
2016-2025
Foundation University
2016
Hospital Infantil Universitario Niño Jesús
2003-2006
Université de Lille
2006
Institut Cochin
2005
Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale
2005
Inserm
2005
Université Paris Cité
2005
Hospital Universitario La Paz
2004
We intend to assess the utility of high-sensitivity C-reactive protein (hs-CRP) as a marker cardiovascular risk in obese children and adolescents.The study included adolescents between 6 18 years age with body mass index (BMI) higher than 2 SDS. All patients had their blood pressure taken hs-CRP, hepatic function, lipid profile uric acid were determined after 12 h fasting. Likewise, an oral glucose tolerance test was performed, determining basal insulin levels, stimulus. considered presence...
Abstract Background Genetic Hypophosphatemic Rickets (HR) is a group of diseases characterized by renal phosphate wasting with inappropriately low or normal 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D) serum levels. The most common form HR X-linked dominant (XLHR) which caused inactivating mutations in the PHEX gene. purpose this study was to perform genetic diagnosis cohort patients clinical HR, genotype-phenotype correlations those and compare our data other studies. Methods Forty three...
Central precocious puberty (CPP) has been associated with loss-of-function mutations in 2 paternally expressed genes (MKRN3 and DLK1). Rare defects the DLk1 were also poor metabolic phenotype at adulthood.Our aim was to investigate genetic biochemical aspects of DLK1 a Spanish cohort children CPP without MKRN3 mutations.A large idiopathic (Spanish PUBERE Registry) studied. Genomic deoxyribonucleic acid obtained from 444 individuals (168 index cases) their close relatives. Automatic...
Abstract Context Loss-of-function mutations of makorin RING finger protein 3 (MKRN3) are the most common monogenic cause familial central precocious puberty (CPP). Objective To describe clinical and hormonal features a large cohort patients with CPP due to MKRN3 compare characteristics different types genetic defects. Methods Multiethnic 716 or idiopathic screened for using Sanger sequencing. A group 156 Brazilian girls (ICPP) was used as control group. Results Seventy-one (45 26 boys from...
Summary Background Higher body mass index ( BMI ) has been associated with earlier pubertal development. Objective The aim of this longitudinal study was to determine menarcheal age in a S panish cohort and assess its association anthropometric variables at birth, childhood adolescence. We also analyse whether the tracking weight between different ages could affect timing menarche. Methods sample population included 195 randomly selected 6–8‐year‐old girls who participated baseline F our P...
Sleep problems are prevalent among individuals with autism spectrum disorder (ASD), and a role has been attributed to melatonin in this multifactorial comorbidity.A cross-sectional study was conducted on 41 autistic children adolescents (9.9 ± 3.02) 24 normal intellectual function (8.42 2.43) were used as controls. Subjects matched for sex, body mass index, pubertal stage, all drug-naive. Circadian sleep parameters studied using an ambulatory circadian monitoring (ACM) device, saliva samples...
To determine the effect of initial metabolic imbalance and its restoration after insulin therapy on adiponectin acylated ghrelin levels in children with type 1 diabetes mellitus (T1DM).Twenty prepubertal newly diagnosed T1DM were prospectively studied at diagnosis 4 months therapy. Body mass index (BMI) serum adiponectin, resistin, total ghrelin, leptin, tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6) determined. The control group comprised 40 healthy children.BMI was decreased...
Idiopathic central precocious puberty (ICPP) is the premature activation of hypothalamic-pituitary-gonadal axis in absence organic disease. Up to now, just gain-of-function mutations KISS1/KISS1R and loss-of-function maternally imprinted gene MKRN3 are known genetic causes ICPP. Our intention evaluate variants present genes related pubertal onset pathway that could act as disease-causing or predisposing variants.We studied clinical exome 20 patients diagnosed with ICPP using Illumina...
Introduction Our objective was to compare high-sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and obesity. Additionally, we aimed analyze the association between hsCRP glycemic control measured by glycohemoglobin A (HbA1c) anthropometric biochemical variables. Research design methods We conducted a non-randomized descriptive study of diabetes matched for sex age group recorded parameters studied variables related blood pressure, lipid...
Familial male-limited precocious puberty is a rare cause of due to activating mutations the LH receptor, leading early onset virilization and short stature. Two therapeutic approaches have been proposed: P450 cytochrome inhibitor ketoconazole or combined treatment with spironolactone testolactone. Results on adult heights not reported date after these two treatments, in this study we present results from five patients treated at median dose 16.2 mg/kg.d for 6.2 yr. Adult height was 173 cm...
Puberty can affect vitamin D levels.The goal of this study was to analyze the relation between deficiency and puberty in obese Spanish children, along with possible interrelation status degree insulin resistance.A cross-sectional carried out, which clinical biochemical data were gathered from 120 50 normal weight children January 2011 2013.Mean levels 19.5 31.6 ng/mL pubertal prepubertal respectively. About 75% subjects 46% had deficiency. Vitamin significantly lower pubescent compared...
Abstract Context Pappalysins (PAPP-A, PAPP-A2) modulate body growth by increasing insulin-like factor I (IGF-I) bioavailability through cleavage of binding proteins (IGFBPs) and are inhibited stanniocalcins (STC1, STC2). Normative data on these novel factors, as well free IGF-I uncleaved fractions IGFBPs, not established. Objective This work aimed to determine serum concentrations PAPP-A, PAPP-A2, STC1, STC2 in relationship with other hormone (GH)-IGF axis parameters during development....
The influence of diet on inflammation in children remains unclear. We aimed to analyze the high-sensitivity C-reactive protein (hs-CRP) levels a pre-pubertal population free other influences that may affect hs-CRP levels. determined 571 six- eight-year-old using an ELISA kit. Information food and nutrient intake was obtained through food-frequency questionnaire. Overall dietary quality assessed Healthy Eating Index (HEI). found girls highest tertile had higher saturated fatty acid, lower...
Familial male-limited precocious puberty is a dominant autosomal genetic disease caused by activating LH receptor gene mutations, clinically expressed only in males. In preliminary studies, addition to the expected testosterone increase, we found high inhibin B levels before age of normal puberty.The objective study was assess cellular origin serum thanks testis section immunostaining.Serum testosterone, gonadotropin, B, pan-alphaC-inhibin, and anti-Mullerian hormone were measured....