A5060129748- Chronic Kidney Disease and Diabetes
- Health disparities and outcomes
- Renal Diseases and Glomerulopathies
- Cardiovascular Health and Risk Factors
- Dialysis and Renal Disease Management
- Mobile Health and mHealth Applications
- Blood Pressure and Hypertension Studies
- Obesity, Physical Activity, Diet
- Physical Activity and Health
- Heart Failure Treatment and Management
- Liver Disease Diagnosis and Treatment
- Urban Transport and Accessibility
- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Acute Kidney Injury Research
- Smoking Behavior and Cessation
- Food Security and Health in Diverse Populations
- Lipoproteins and Cardiovascular Health
- Renal and related cancers
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes Management and Research
- Healthcare Systems and Public Health
- Sodium Intake and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
Boston University
2023-2025
Boston Medical Center
2020-2025
Health First
2024
National Institutes of Health
2018-2022
National Heart Lung and Blood Institute
2018-2022
Wake Forest University
2018-2020
Lung Institute
2019
Sanofi (France)
2013
Collège de France
2001
Inserm
2001
Albuminuria is a major risk factor for chronic kidney disease (CKD) progression, especially when categorized as moderate (30 to 300 mg/g) or severe (>300 mg/g). However, there are limited data on the prognostic value of albuminuria within normoalbuminuric range (<30 in persons with CKD.
Background: It is imperative to critically evaluate the prognostic implications of Cardiovascular-Kidney-Metabolic (CKM) syndrome staging inform clinical practice. The primary aims this paper were define risk mortality associated with each CKM stage and determine corresponding restricted mean survival time over a 15-year period. Methods: This longitudinal study 50,678 community-dwelling U.S. adults aged 20 older baseline data for determination participating in 1999-2018 National Health...
Little is known about the spatial clustering of neighborhood deprivation across United States (US). Using data from 2010 US Census Bureau, we created a index (NDI: higher NDI indicates deprivation/ lower socioeconomic status) for each county within County level scores were loaded into ArcGIS 10.5.1 where they mapped and analyzed using Moran's I Anselin Local I. Ultimately, varies spatially US. The highest found in Southeastern Southwestern states, inland regions Southern California. This...
The aim of this study is to determine whether elevated levels albuminuria within the low range [urinary albumin-to-creatinine ratio (UACR) <30 mg/g] are linked cardiovascular death in adults lacking major risk factors. association between UACR and mortality was investigated among 12 835 participants 1999-2014 National Health Nutrition Examination Survey using Cox proportional hazard models confounder-adjusted survival curves. We excluded with baseline disease, hypertension, diabetes,...
Journal Article Albuminuria References Ranges in Healthy US Adults Get access Sophie E Claudel, Claudel Department of Medicine, Boston Medical Center, Boston, MA, United States https://orcid.org/0000-0002-7695-4674 Search for other works by this author on: Oxford Academic Google Scholar Sushrut S Waikar, Waikar Section Nephrology, University Chobanian and Avedisian School Ashish Verma Address correspondence to at: 14 Evans Biomedical Research & X-521, 650 Albany St., MA 02118, States. E-mail...
Socioeconomically disadvantaged neighborhoods have been associated with poor health outcomes. Little is known about the biological mechanism by which deprived neighborhood conditions exert negative influences on health. Data from 1999-2002 National Health and Nutrition Examination Surveys (NHANES) were used to assess relationship between deprivation index (NDI) log-transformed leukocyte telomere length (LTL) via multilevel modeling control for census tract level clustering. Models...
Community-based participatory research is an effective tool for improving health outcomes in minority communities. Few community-based studies have evaluated methods of optimizing smartphone apps technology-enabled interventions African Americans.This study aimed to utilize focus groups (FGs) gathering qualitative data inform the development app that promotes physical activity (PA) among American women Washington, DC.We recruited a convenience sample (N=16, age range 51-74 years) from...
Hirschsprung's disease (HSCR) is one the most common congenital intestinal disease. It leads to aganglionic megacolon in early childhood. Several susceptibility genes have been identified: RET protooncogene and its ligand, glial cell derived neutrophic factor (GDNF), Sox 10, Endothelin-3 (EDN3) receptor B (EDNRB). EDNRB mutations are found 5% of familial or sporadic HSCR. Only few HSCR explored some them seem be non fonctional variants. The properties three mutant human endothelin (hETB)...
Introduction A mixed-method, co-design approach to studying the adoption of mobile health (mHealth) technology among African-American (AA) women has not been fully explored. Qualitative data may contextualise existing knowledge surrounding perceptions mHealth AA as part formative work for designing a physical activity application (app). Methods convenience sample 16 completed an informatics survey prior participating in focus groups exploring their use and apps. Survey responses provided...
Background: Psychosocial stress correlates with cardiovascular (CV) events; however, associations between physiologic measures of stressors and CVD remain incompletely understood, especially in racial/ethnic minority populations resource-limited neighborhoods. We examined chronic stress-related neural activity, measured by amygdalar 18 Fluorodeoxyglucose ( FDG) uptake, aortic vascular FDG uptake (arterial inflammation measure) a community-based cohort. Methods: Forty participants from the...
Neighborhood socioeconomic disadvantage may contribute to depression. This study examined associations between neighborhood disadvantage, measured as deprivation, and depression severity within a broadly representative sample of the U.S. adult population. The (n = 6308 adults) was from 2011-2014 National Health Nutrition Examination Survey. deprivation calculated using 2010 Census shown in tertile form. Depression responses Patient Questionnaire-9 (PHQ-9) continuous score binary Clinically...
Neighborhood environment perception (NEP) has been associated with health outcomes. However, little is known about how NEP relates to routine healthcare utilization. This study investigated the relationship between and independent subfactors utilization behavior, as measured by self-reported (1) usual source of (2) time since last check-up. We used cross-sectional data from Dallas Heart Study, which features a diverse, probability-based sample County residents ages 18 65. logistic regression...
Patients with end-stage renal disease (ESRD) have a high burden of physical and psychological symptoms. Many remain unrecognized for long periods time, particularly in older adults. The best strategy to monitor patient-reported outcome measures (PROMs) has not been identified.
SAR228810 is a humanized monoclonal antibody (mAb) binding specifically to soluble protofibrillar and fibrillar forms of Aβ peptide. Compared other anti-A β mAb, does not neutralize monomers or low molecular weight complexes. Accordingly, binds congophilic amyloid plaques (present only in Alzheimer's Disease (AD) patients) diffuse deposits most aged cases). was designed with an engineered immunoglobulin G4 framework that reduces risk ARIA. The IgG1 anti-amyloid mAb carries the Fc g...
There is no established method for processing data from commercially available physical activity trackers. This study aims to develop a standardized approach defining valid wear time use in future interventions and analyses. Sixteen African American women (mean age = 62.1 years mean body mass index 35.5 kg/m2) wore the Fitbit Charge 2 20 days. Method 1 defined day as ≥10-hr with heart rate data. removed minutes without data, ≤ - SDs below ≤2 steps, nighttime. Linear regression modeled steps...
Abstract Background To inform public health policies regarding disease management, it is crucial to comprehend the prevalence and mortality rates linked various stages of Cardiovascular-Kidney-Metabolic (CKM) syndrome. Methods A longitudinal study was conducted using National Health Nutrition Examination Survey (NHANES) data (1999-2018) from 50,624 U.S. adults, defining CKM syndrome based on 2023 American Heart Association (AHA) Presidential Advisory Statement. The investigation aimed assess...