Brian Clarke
A5052353077- Acute Ischemic Stroke Management
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Heart Failure Treatment and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Imaging and Diagnostics
- Muscle Physiology and Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Cardiac Arrest and Resuscitation
- Renal Transplantation Outcomes and Treatments
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Atrial Fibrillation Management and Outcomes
- Water Systems and Optimization
- Cerebrovascular and Carotid Artery Diseases
- Cardiac pacing and defibrillation studies
- Stroke Rehabilitation and Recovery
- Child Nutrition and Water Access
- Traumatic Brain Injury and Neurovascular Disturbances
- Viral Infections and Immunology Research
- Venous Thromboembolism Diagnosis and Management
- Infrastructure Maintenance and Monitoring
- Cardiac Health and Mental Health
- Ubiquitin and proteasome pathways
University of British Columbia
2023-2024
St. Paul's Hospital
2023-2024
St George’s University Hospitals NHS Foundation Trust
2020-2024
University of Pavia
2023-2024
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
Shore Memorial Hospital
2023
Libin Cardiovascular Institute of Alberta
2016-2022
University of Calgary
2016-2022
New York Proton Center
2022
Skeletal muscle adapts to decreases in activity and load by undergoing atrophy. To identify candidate molecular mediators of atrophy, we performed transcript profiling. Although many genes were up-regulated a single rat model only small subset was universal all atrophy models. Two these encode ubiquitin ligases: Muscle RING Finger 1 ( MuRF1 ), gene designate Atrophy F-box MAFbx the latter being member SCF family E3 ligases. Overexpression myotubes produced whereas mice deficient either or...
Extracellular signals often result in simultaneous activation of both the Raf-MEK-ERK and PI3K-Akt pathways (where ERK is extracellular-regulated kinase, MEK mitogen-activated protein kinase or PI3K phosphatidylinositol 3-kinase). However, these two signaling were shown to exert opposing effects on muscle cell hypertrophy. Furthermore, pathway was inhibit pathway; this cross-regulation depended differentiation state cell: Akt inhibited differentiated myotubes, but not their myoblast...
Molecular mechanisms underlying sarcopenia, the age-related loss of skeletal muscle mass and function, remain unclear. To identify molecular changes that correlated best with sarcopenia might contribute to its pathogenesis, we determined global gene expression profiles in muscles rats aged 6, 12, 18, 21, 24, 27 months. These exhibit beginning at 21 Correlation versus or age changes, functional annotation analysis identified signatures distinct from aging. Specifically, mitochondrial energy...
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist can be challenging to treat. Pharmacologically based rhythm control of AF has not proven superior rate control. Ablation-based was compared with evaluate if clinical outcomes in patients HF could improved. Methods: This a multicenter, open-label trial blinded outcome evaluation using central adjudication committee. Patients high-burden paroxysmal (>4 episodes 6 months) or persistent (duration <3 years) AF,...
Abstract Background and aim Neutrophil-lymphocyte ratio (NLR) lymphocyte-monocyte (LMR) are associated with clinical outcomes in malignancy, cardiovascular disease stroke. Here we investigate their association outcome after acute ischaemic stroke treated by mechanical thrombectomy (MT). Methods Patients were selected using audit data for MT anterior circulation at a UK centre from May 2016–July 2017. Clinical laboratory including neutrophil, lymphocyte monocyte count tested before 24 h...
The mRNA vaccines against COVID-19 infection have been effective in reducing the number of symptomatic cases worldwide. With widespread uptake, case series vaccine-related myocarditis/pericarditis reported, particularly adolescents and young adults. Men tend to be affected with greater frequency, symptom onset is usually within 1 week after vaccination. Clinical course appears mild most cases. On basis available evidence, we highlight a clinical framework guide providers on how assess,...
Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown.
Abstract Introduction There are few randomized clinical trials in vascular cognitive impairment (VCI). This trial tested the hypothesis that PDE5 inhibitor tadalafil, a widely used vasodilator, increases cerebral blood flow (CBF) older people with symptomatic small vessel disease, main cause of VCI. Methods In double‐blind, placebo‐controlled, cross‐over trial, participants received tadalafil (20 mg) and placebo on two visits ≥7 days apart (randomized to order treatment). The primary...
Purpose: Recombinant human interleukin-1 receptor antagonist (anakinra) is an anti-inflammatory with efficacy in animal models of stroke. We tested the effect anakinra on perihaematomal oedema acute intracerebral haemorrhage (ICH) and explored effects inflammatory markers. Methods: conducted a multicentre, randomised, double-blind, placebo-controlled trial patients acute, spontaneous, supratentorial ICH between May 2019 February 2021. Patients were randomised to 100 mg subcutaneous within 8...
A differential scanning calorimetric study was done on raw and parboiled rice to determine the degree of gelatinization. Unparboiled absorbed highest amount endothermic heat, enthalpy change gradually decreasing with increasing hot soaking time. The gelatinization achieved when paddy soaked for 120 min at 80 °C. With gelatinization, yield point in a compression test also increased. During parboiling process internal fissures were healed, resulting higher head during milling.
In diabetes mellitus the morbidity and mortality of cardiovascular disease is increased represents an important independent mechanism by which heart exacerbated. The pathogenesis diabetic cardiomyopathy involves enhanced activation PPAR transcription factors, including PPARα, to a lesser degree PPARβ PPARγ1. How these factors are regulated in largely unknown. Recent studies have described post-translational ubiquitination PPARs as ways activity inhibited cancer. However, specific mechanisms...
Background The overlap between cancer and cardiovascular care continues to expand, with intersections emerging before, during, following therapies. To date, emphasis has been placed on how therapeutics influence downstream cardiac health. However, whether active malignancy itself influences chamber volumes, function, or overall myocardial tissue health remains uncertain. We sought perform a comprehensive magnetic resonance‐based evaluation of in patients chemotherapy‐naïve comparison healthy...
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether DOAC treatment associated with a benefit (NCB). Design, Setting, and Participants This was post hoc analysis the Early Versus Late Initiation Direct Oral Anticoagulants in Post–Ischaemic Stroke Patients With Atrial Fibrillation (ELAN) open-label randomized trial conducted across 103 sites 15...