A5011647323- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Cardiac tumors and thrombi
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- ECG Monitoring and Analysis
- Cardiovascular Syncope and Autonomic Disorders
- Pharmacogenetics and Drug Metabolism
- Infective Endocarditis Diagnosis and Management
- Venous Thromboembolism Diagnosis and Management
- Ion channel regulation and function
- Cardiac, Anesthesia and Surgical Outcomes
- Lipoproteins and Cardiovascular Health
- Cardiomyopathy and Myosin Studies
- Contact Dermatitis and Allergies
- Health Systems, Economic Evaluations, Quality of Life
- Neurological disorders and treatments
- Antimicrobial Resistance in Staphylococcus
- Vascular anomalies and interventions
- Social Work Education and Practice
- Heart Rate Variability and Autonomic Control
Université Laval
2016-2025
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2015-2024
Royal Ottawa Mental Health Centre
2024
Montreal Heart Institute
2007-2023
Laboratoire Lorrain de Recherche en Informatique et ses Applications
2023
University of British Columbia
2023
University of Zurich
2023
Lung Institute
2021
Cegep de Sainte Foy
2003-2018
McGill University Health Centre
2016
It is common practice to restore and maintain sinus rhythm in patients with atrial fibrillation heart failure. This approach based part on data indicating that a predictor of death failure suggesting the suppression may favorably affect outcome. However, benefits risks this have not been adequately studied.We conducted multicenter, randomized trial comparing maintenance (rhythm control) control ventricular rate (rate left ejection fraction 35% or less, symptoms congestive failure, history...
Background: Atrial fibrillation (AF) and heart failure (HF) frequently coexist can be challenging to treat. Pharmacologically based rhythm control of AF has not proven superior rate control. Ablation-based was compared with evaluate if clinical outcomes in patients HF could improved. Methods: This a multicenter, open-label trial blinded outcome evaluation using central adjudication committee. Patients high-burden paroxysmal (>4 episodes 6 months) or persistent (duration <3 years) AF,...
Background— Postoperative atrial fibrillation (POAF) is a highly prevalent complication after cardiac surgery with substantial effects on outcomes. Previous studies have reported that obesity risk factor for POAF surgery. However, it unknown whether the metabolic syndrome (MS) also increases of postoperative fibrillation. Methods and Results— We retrospectively analyzed association between MS incidence new-onset in total 5085 patients who underwent isolated coronary artery bypass grafting no...
Diagnosis of arrhythmic disorders is challenging because their short-lasting, intermittent character. Conventional technologies noninvasive ambulatory rhythm monitoring are limited by modest sensitivity. We present a novel form wearable electrocardiogram (ECG) sensors providing an alternative tool for long-term with the potential increased sensitivity to detect or subclinical arrhythmia. The objective was assess signal quality and R-R coverage ECG sensor system compared standard 3-lead...
Background: Left atrial appendage closure is an established therapy in patients with fibrillation. Although device-related thrombosis (DRT) relatively rare, it potentially linked to adverse events. As data on DRT characteristics, outcome, and treatment regimen are scarce, we aimed assess these questions a multicenter approach. Methods: One hundred fifty-six the diagnosis of after left were included multinational EUROC-DRT registry. Baseline characteristics clinical echocardiographic data....
Growing evidence has demonstrated the clinical benefit of percutaneous left atrial appendage closure (LAAC) in patients with fibrillation. Although procedural complication rates have declined increasing experience, post-procedural device-related complications persist, impacting prognosis and reducing long-term benefits procedure. Given potential impact these complications, surveillance imaging after LAAC is mandatory. Currently, different modalities offer unique advantages to manage which...
We recently demonstrated that metabolic syndrome (MetS) is an independent risk factor for postoperative atrial fibrillation (POAF) following coronary artery bypass grafting (CABG). In the present work, we sought to determine which feature of MetS associated with POAF. retrospectively analysed association between features and incidence new-onset POAF in a total 2214 male patients <65 years who underwent first isolated CABG. Anthropometric data including waist circumference (WC) complete...
Background —Several cases of unexpected death have been reported with sildenafil in patients predisposed to ischemic cardiac events. Although acute episodes ischemia could account for some these deaths, we hypothesized that may unsuspected electrophysiological effects predisposing proarrhythmia. Methods and Results —Studies were undertaken 10 isolated guinea pig hearts demonstrated prolongation repolarization a reverse use-dependent manner by 30 μmol/L. Action potential duration increased...
CYP2D6 is involved in the O-demethylation metabolic pathway of venlafaxine humans. In this study, we investigated whether isozyme stereoselective. Plasma samples from seven extensive metabolizers (EMs) and five poor (PMs), collected during a period without with coadministration quinidine, were analysed. Subjects administered hydrochloride 18.75 mg orally every 12 h for 48 on two occasions (1 week apart); once alone concomitant administration quinidine sulphate h. Blood urine under...
CYP2D6 is the major enzyme involved in metabolism of venlafaxine. Subjects with a low activity have increased plasma concentrations venlafaxine that may predispose them to cardiovascular side effects. In vitro and vivo studies showed diphenhydramine, nonprescription antihistamine, can inhibit activity. Therefore, authors investigated this study potential drug interaction between diphenhydramine Fifteen male volunteers, nine extensive metabolizer (EM) six poor (PM) phenotype CYP2D6, received...