A5003836938- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Cardiac tumors and thrombi
- Cardiac pacing and defibrillation studies
- Aortic Disease and Treatment Approaches
- Cardiovascular Function and Risk Factors
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular and Diving-Related Complications
- Heart rate and cardiovascular health
- Acute Myocardial Infarction Research
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Mechanical Circulatory Support Devices
- Cardiac, Anesthesia and Surgical Outcomes
- Viral Infections and Immunology Research
- Angiogenesis and VEGF in Cancer
- Transplantation: Methods and Outcomes
- Cardiac Structural Anomalies and Repair
- Cardiovascular Disease and Adiposity
- Coronary Artery Anomalies
University Hospital of Bern
2015-2024
Medical University of Vienna
2024
University of Bern
2012-2020
Schwarzwald-Baar Klinikum
2013-2020
University of Kansas Medical Center
2018
Inserm
2016
Arcispedale Sant'Anna
2016
Hôpital Européen Georges-Pompidou
2016
Assistance Publique – Hôpitaux de Paris
2016
Université Paris Cité
2016
Background— The prognostic relevance of the collateral circulation is still controversial. goal this study was to assess impact on survival quantitatively obtained, recruitable coronary flow in patients with stable artery disease during 10 years follow-up. Methods and Results— Eight-hundred forty-five individuals (age, 62±11 years), 106 without 739 chronic disease, underwent a total 1053 quantitative, pressure–derived measurements between March 1996 April 2006. All were prospectively...
Coronary artery disease (CAD) is frequently present in patients with severe aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI). While revascularisation affects peri-operative outcome surgical replacement, the impact of percutaneous coronary intervention (PCI) TAVI not well established.Consecutive AS were prospectively included into Bern registry. In CAD, myocardium at risk was assessed using DUKE myocardial jeopardy score. Revascularisation performed by means PCI either...
The aim of this study was to evaluate whether coronary artery disease (CAD) severity exerts a gradient risk in patients with aortic stenosis (AS) undergoing transcatheter valve implantation (TAVI). A total 445 severe AS TAVI were included into prospective registry between 2007 and 2012. preoperative SYNTAX score (SS) determined from baseline angiograms. In case revascularization prior TAVI, residual SS (rSS) also determined. Clinical outcomes compared without CAD (n = 158), low (0–22, n...
Transcatheter aortic valve implantation (TAVI) is an established treatment alternative to surgical replacement in high-risk and inoperable patients outcomes among with estimated low or intermediate risk remain be determined. The aim of this study was assess clinical undergoing TAVI.Between August 2007 October 2011, 389 consecutive underwent TAVI were categorized according the Society Thoracic Surgeons (STS) score into (STS < 3%; n = 41, 10.5%), ≥3% ≤8%, 254, 65.3%), > 8%; 94, 24.2%) groups...
To report a 10-year single center experience with Amplatzer devices for left atrial appendage (LAA) occlusion.Intermediate-term outcome data following LAA occlusion are scarce.Short- and intermediate-term outcomes of patients who underwent were assessed. All procedures performed under local aesthesia without transesophageal echocardiography. Patients discharged on acetylsalicylic acid clopidogrel 1-6 months.LAA was attempted in 152 (105 males, age 72 ± 10 years, CHA2 DS2 -Vasc-score 3.4 1.7,...
Atrial fibrillation (AF) is an important risk factor for stroke and common among elderly patients undergoing transcatheter aortic valve implantation. The aim of this study was to assess the impact AF on clinical outcomes implantation.Between August 2007 October 2011, a total 389 high-risk implantation were included into prospective registry. recorded in 131 (33.7%) with mean CHA(2)DS(2)-VASC score 4.5±1.2 paroxysmal 26 (25.0%), persistent 8 (7.7%), permanent 70 (67.3%). Patients without had...
Cerebrovascular accidents (CVA) are considered among the most serious adverse events after transcatheter aortic valve implantation (TAVI). The objective of present study was to evaluate frequency and timing CVA TAVI investigate impact on clinical outcomes within 30 days procedure.Between August 2007 October 2011, 389 high-risk elderly patients with symptomatic severe stenosis underwent via transfemoral, transapical or subclavian access. A total 14 (3.6%) experienced at least one follow-up...
To evaluate the performance of periscope and/or chimney grafts (CPGs) in endovascular treatment pararenal or thoracoabdominal aneurysms using off-the-shelf devices.Between February 2002 and August 2012, 77 consecutive patients (62 men; mean age 73±9 years) suffering from aortic (n=55), (n=16), arch to visceral artery (n=6) were treated with stent-graft implantation requiring maintain side branch perfusion. CPGs planned advance not used as bailout. A standardized follow-up protocol including...
Background: Left atrial appendage closure is an established therapy in patients with fibrillation. Although device-related thrombosis (DRT) relatively rare, it potentially linked to adverse events. As data on DRT characteristics, outcome, and treatment regimen are scarce, we aimed assess these questions a multicenter approach. Methods: One hundred fifty-six the diagnosis of after left were included multinational EUROC-DRT registry. Baseline characteristics clinical echocardiographic data....
The aim of this study was to characterize aortic root dimensions patients with valve stenosis undergoing transcatheter replacement (TAVR) and evaluate sex differences. advent TAVR makes a precise delineation the anatomy mandatory requires profound anatomic understanding. Patients planned undergo underwent screening imaging use 64-slice or dual-source electrocardiogram-gated contrast-enhanced computed tomography. Anatomic were assessed at level left ventricular outflow tract (LVOT), annulus,...
<h3>Background</h3> The efficacy of external counterpulsation (ECP) on coronary collateral growth has not been investigated in a randomised controlled study. <h3>Objective</h3> To test the hypothesis that ECP augments function during 1 min balloon occlusion. <h3>Patients and methods</h3> Twenty patients with chronic stable artery disease were studied. Before after 30 h randomly allocated (20 90 sessions over 4 weeks at 300 mm Hg inflation pressure) or sham (same setting 80 pressure),...
FUNDAMENTO: A oclusão percutânea do apêndice atrial esquerdo (OAAE) surgiu como alternativa à anticoagulação oral (AO) para prevenção acidente vascular cerebral (AVC) em pacientes com fibrilação não-valvular (FANV). OBJETIVO: Relatar os resultados imediatos e o seguimento clínico de submetidos a OAAE Amplatzer Cardiac Plug (ACP) um único centro referência. MÉTODOS: Oitenta seis consecutivos FANV, contra-indicação AO escore CHADS2= 2,6±1,2 foram implante ACP. Realizou-se ecocardiográfico no...
Anemia is frequent among patients with cardiovascular disease and adversely affects prognosis. The objective of this analysis was to assess the impact anemia on long-term clinical outcomes undergoing percutaneous coronary intervention (PCI) unrestricted use drug-eluting stents (DES).Between April 2002 March 2009, 6528 consecutive underwent PCI DES. Among according criteria by World Health Organization (WHO) (hemoglobin <130 g/L for men <120 women, respectively) below 25(th) percentile...
Aims:We sought to analyse local distribution of aortic annulus and left ventricular outflow tract (LVOT) calcification in patients undergoing transcatheter valve replacement (TAVR) its impact on regurgitation (AR) immediately after device placement. Methods results:A group 177 with severe stenosis multislice computed tomography the root followed by TAVR were enrolled this single-centre study.Annular LVOT calcifications assessed per cusp using a semi-quantitative grading system (0: none; 1...
Background Acute complete occlusion of a coronary artery results in progressive ischemia, moving from the endocardium to epicardium (ie, wavefront). Dependent on time reperfusion and collateral flow, myocardial infarction ( MI ) will manifest, with transmural portending poor prognosis. Late gadolinium enhancement cardiac magnetic resonance imaging can detect high diagnostic accuracy. Primary percutaneous intervention is preferred strategy patients ST -segment-elevation <12 hours symptom...
The efficacy of granulocyte colony-stimulating factor (G-CSF) for coronary collateral growth promotion and thus impending myocardial salvage has not been studied so far, to our best knowledge.In 52 patients with chronic stable artery disease, age 62+/-11 years, the effect on a marker infarct size (ECG ST segment elevation) quantitative function during 1-minute balloon occlusion was tested in randomized, placebo-controlled, double-blind fashion. study protocol before intervention consisted...
<h3>Objective</h3> To evaluate the effect of heart rate reduction by ivabradine on coronary collateral function in patients with chronic stable artery disease (CAD). <h3>Methods</h3> This was a prospective randomised placebo-controlled monocentre trial university hospital setting. 46 CAD received placebo (n=23) or for duration 6 months. The main outcome measure flow index (CFI) as obtained during 1 min balloon occlusion at study inclusion (baseline) and 6-month follow-up examination. CFI is...