A5055228344- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- ECG Monitoring and Analysis
- Cardiac pacing and defibrillation studies
- Cardiac Arrhythmias and Treatments
- Innovative Energy Harvesting Technologies
- Atrial Fibrillation Management and Outcomes
- Ultrasound and Hyperthermia Applications
- Wireless Power Transfer Systems
- Cardiac electrophysiology and arrhythmias
- Energy Harvesting in Wireless Networks
- Ion channel regulation and function
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Acute Myocardial Infarction Research
- Infective Endocarditis Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Connexins and lens biology
- Mechanical Circulatory Support Devices
- Aortic aneurysm repair treatments
- Cardiac and Coronary Surgery Techniques
- Hemodynamic Monitoring and Therapy
- Nicotinic Acetylcholine Receptors Study
- Analog and Mixed-Signal Circuit Design
Solothurner Spitäler
2013-2024
Fistula Foundation
2020
University Hospital of Bern
2005-2019
University of Bern
2006-2017
Bern University of Applied Sciences
2012
Institute of Social and Preventive Medicine
2009-2011
Triemli Hospital
2011
University Hospital of Zurich
2011
World Health Organization
2009
CVPath Institute
2009
Stent thrombosis may occur late after drug-eluting stent (DES) implantation, and its cause remains unknown. The present study investigated differences of the stented segment between patients with without very use intravascular ultrasound.Since January 2004, presenting (> 1 year) DES implantation underwent ultrasound. Findings in were compared ultrasound routinely obtained 8 months 144 control patients, who did not experience for > or = 2 years. Very was encountered 13 at a mean 630+/-166...
Intravascular ultrasound of drug-eluting stent (DES) thrombosis (ST) reveals a high incidence incomplete apposition (ISA) and vessel remodeling. Autopsy specimens DES ST show delayed healing hypersensitivity reactions. The present study sought to correlate histopathology thrombus aspirates with intravascular findings in patients very late ST.The population consisted 54 (28 26 controls). Of 28 ST, 10 (1020+/-283 days after implantation) 11 segments (5 sirolimus-eluting stents, 5...
Background— The prognostic relevance of the collateral circulation is still controversial. goal this study was to assess impact on survival quantitatively obtained, recruitable coronary flow in patients with stable artery disease during 10 years follow-up. Methods and Results— Eight-hundred forty-five individuals (age, 62±11 years), 106 without 739 chronic disease, underwent a total 1053 quantitative, pressure–derived measurements between March 1996 April 2006. All were prospectively...
Long-term comparative data of first-generation drug-eluting stents are scarce. We investigated clinical and angiographic outcomes sirolimus-eluting (SES) paclitaxel-eluting (PES) at 5 years as part the Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization (SIRTAX) LATE study.A total 1012 patients were randomly assigned to SES or PES. Repeat angiography was completed in 444 (43.8%) years. Major adverse cardiac events occurred 19.7% SES- 21.4% PES-treated (hazard...
Late acquired incomplete stent apposition (ISA) is more common after drug-eluting (DES) than bare metal (BMS) implantation and has been associated with vascular hypersensitivity thrombosis (ST). We investigated the impact of incidentally discovered ISA as assessed by intravascular ultrasound (IVUS) 8 months DES on long-term clinical outcome. A total 194 patients 221 lesions were prospectively followed through 5 years. At months, IVUS showed evidence among 37 39 (18%) (mean ISAmax 4.7 ± 5.0...
BACKGROUND Contemporary pacemakers (PMs) are powered by primary batteries with a limited energy-storing capacity.PM replacements because of battery depletion common and unpleasant bear the risk complications.Batteryless PMs that harvest energy inside body may overcome these limitations.OBJECTIVE The goal this study was to develop batteryless PM solar module converts transcutaneous light into electrical energy.METHODS Ex vivo measurements were performed modules placed under pig skin flaps...
<h3>Background</h3> The efficacy of external counterpulsation (ECP) on coronary collateral growth has not been investigated in a randomised controlled study. <h3>Objective</h3> To test the hypothesis that ECP augments function during 1 min balloon occlusion. <h3>Patients and methods</h3> Twenty patients with chronic stable artery disease were studied. Before after 30 h randomly allocated (20 90 sessions over 4 weeks at 300 mm Hg inflation pressure) or sham (same setting 80 pressure),...
Today's cardiac pacemakers are powered by batteries with limited energy capacity. As the battery's lifetime ends, pacemaker needs to be replaced. This surgical re-intervention is costly and bears risk of complications. Thus, a without primary desirable. The goal this study was test whether transcutaneous solar light could power pacemaker.We used three-step approach investigate feasibility sunlight-powered pacing. First, harvestable estimated. Theoretically, subcutaneously implanted 1 cm(2)...
A new pseudo asynchronous level crossing analogue-to-digital converter (adc) architecture targeted for low-power, implantable, long-term biomedical sensing applications is presented. In contrast to most of the existing adc designs, proposed design has no digital-to-analogue (dac) and continuous time comparators. Instead, uses an analogue memory cell dynamic The retains signal activity dependent sampling operation by generating events only when input changing. offers advantages smaller chip...
The efficacy of granulocyte colony-stimulating factor (G-CSF) for coronary collateral growth promotion and thus impending myocardial salvage has not been studied so far, to our best knowledge.In 52 patients with chronic stable artery disease, age 62+/-11 years, the effect on a marker infarct size (ECG ST segment elevation) quantitative function during 1-minute balloon occlusion was tested in randomized, placebo-controlled, double-blind fashion. study protocol before intervention consisted...
<h3>Objective</h3> To evaluate the effect of heart rate reduction by ivabradine on coronary collateral function in patients with chronic stable artery disease (CAD). <h3>Methods</h3> This was a prospective randomised placebo-controlled monocentre trial university hospital setting. 46 CAD received placebo (n=23) or for duration 6 months. The main outcome measure flow index (CFI) as obtained during 1 min balloon occlusion at study inclusion (baseline) and 6-month follow-up examination. CFI is...
Active electronic implants are powered by primary batteries, which induces the necessity of implant replacement after battery depletion. This causes repeated interventions in a patients' life, bears risk complications and is costly. By using energy harvesting devices to power implant, device replacements may be avoided size reduced dramatically. Recently, several groups presented prototypes subcutaneous solar cells. However, data about expected real-life output subcutaneously implanted cells...
cardiac pacemakers require regular medical follow-ups to ensure proper functioning. However, device replacements due battery depletion are common and account for ∼25% of all implantation procedures. Furthermore, conventional pacemaker leads which prone fractures, dislocations or isolation defects. The ensuing surgical interventions increase risks the patients costs that need be avoided.in this study, we present a method harvest energy from endocardial heart motions. We developed novel...
Energy harvesting devices are widely discussed as an alternative power source for todays active implantable medical devices. Repeated battery replacement procedures can be avoided by extending the implants life span, which is goal of energy concepts. This reduces risk complications patient and may even reduce device size. The continuous powerful contractions a human heart ideally qualify substitute. In particular, in close proximity to such pacemakers, defibrillators or bio signal (ECG)...
1 Human HeLa cells expressing mouse connexin30 (Cx30) were used to study the electrical properties of Cx30 gap junction channels. Experiments performed on cell pairs with dual voltage-clamp method. 2 The conductance (gj) at steady state showed a bell-shaped dependence junctional voltage (Vj; Boltzmann fit: Vj,0= 27 mV, gj,min= 0.15, z= 4). instantaneous gj decreased slightly increasing Vj. 3 currents (Ij) declined time following single exponential. constants Ij inactivation (τi) 4 Single...