A5043742793- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Cardiac Arrhythmias and Treatments
- Pain Management and Treatment
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Heart rate and cardiovascular health
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Biosensors and Analytical Detection
- Sociology and Norbert Elias
- Hereditary Neurological Disorders
- Cerebrovascular and Carotid Artery Diseases
- Renal and Vascular Pathologies
- Phonocardiography and Auscultation Techniques
- Cardiac Ischemia and Reperfusion
- Peripheral Artery Disease Management
- Cardiac and Coronary Surgery Techniques
- Central Venous Catheters and Hemodialysis
- Cardiomyopathy and Myosin Studies
Regionalspital Emmental
2022
University Hospital of Bern
2013-2021
University of Bern
1985-2021
Swiss Continence Foundation
2013
University of Basel
1985
<h3>Objective</h3> To evaluate the effect of heart rate reduction by ivabradine on coronary collateral function in patients with chronic stable artery disease (CAD). <h3>Methods</h3> This was a prospective randomised placebo-controlled monocentre trial university hospital setting. 46 CAD received placebo (n=23) or for duration 6 months. The main outcome measure flow index (CFI) as obtained during 1 min balloon occlusion at study inclusion (baseline) and 6-month follow-up examination. CFI is...
In this study we aimed to test the hypothesis that left ventricular (LV) afterload reduction in severe aortic valve stenosis (AS) by transcatheter implantation (TAVI) acutely improves coronary haemodynamics.This was a prospective, pathophysiologic 40 patients with AS undergoing TAVI. Endpoints were determined invasively immediately before and after TAVI without altering stenotic lesions if present. Myocardial hyperaemia induced intravenous adenosine. The primary endpoints flow reserve...
<h3>Objective</h3> To expand the limited information on prognostic impact of quantitatively obtained collateral function in patients with coronary artery disease (CAD) and to estimate causality such a relation. <h3>Design</h3> Prospective cohort study long-term observation clinical outcome. <h3>Setting</h3> University Hospital. <h3>Patients</h3> One thousand one hundred eighty-one chronic stable CAD undergoing 1771 quantitative, pressure-derived flow index measurements, as during 1-min...
Background— Despite the fact that numerous studies have pursued strategy of improving collateral function in patients with peripheral artery disease, there is currently no method available to quantify arterial lower limb. Methods and Results— Pressure-derived flow index (CFIp, calculated as (occlusive pressure−central venous pressure)/(aortic pressure); pressure values mm Hg) left superficial femoral was obtained undergoing elective coronary angiography using a combined pressure/Doppler wire...
The function of naturally existing internal mammary (IMA)-to-coronary artery bypasses and their quantitative effect on myocardial ischemia are unknown.The primary end point this study was collateral flow index (CFI) obtained during two 1-minute coronary balloon occlusions, the first with second without simultaneous distal IMA occlusion. secondary quantitatively determined intracoronary ECG ST-segment elevation. CFI is ratio simultaneously recorded mean occlusive pressure divided by aortic...
Background— The objective of this study is to test the effect permanent right internal mammary artery device closure on coronary collateral function and myocardial ischemia. Methods Results— This was a prospective, open-label clinical trial in 50 patients with disease. primary end point flow index as obtained during 1-minute proximal (RCA) left balloon occlusion at baseline before follow-up examination 6 weeks after distal closure. Collateral ratio between simultaneously recorded mean...
Abstract Background In hospitalized patients with skin and soft tissue infections (SSTIs), intravenous (IV) empiric antibiotic treatment is initiated. The best time point for switching from IV to oral unknown. We used an algorithm-based decision tree the switch antibiotics within 48 hours aimed investigate outcome of this concept. Methods a nonrandomized trial, we prospectively enrolled 128 SSTI July 2019 May 2021 at 3 institutions. Clinical biochemical response data during first week...
<h3>Objective</h3> This study tested the hypotheses that intermittent coronary sinus occlusion (iCSO) reduces myocardial ischaemia, and amount of ischaemia reduction is related to collateral function. <h3>Design</h3> Prospective case-control with intraindividual comparison during two 2-min artery balloon occlusions without simultaneous iCSO by a balloon-tipped catheter. <h3>Setting</h3> University Hospital. <h3>Patients</h3> 35 patients chronic stable disease. <h3>Intervention</h3> iCSO....
Background: The present study aimed to quantitatively measure the pressure-derived function of palmar arch and forearm arterial collateral circulation during transradial access. Methods Results: Palmar was determined using radial artery pressure signals in nonobstructed vessel brief manual occlusions more proximal plus ulnar arteries. Collateral flow index (CFI), ratio mean occlusive divided by nonocclusive blood pressure, both subtracted central venous for CFI occlusion (CFI rad )...
Natural, nonsurgical internal mammary artery (IMA) bypasses to the coronary circulation have been shown function as extracardiac sources of myocardial blood supply. The goal this randomized, placebo-controlled, double-blind trial was test efficacy permanent right IMA (RIMA) device occlusion on (RCA) occlusive supply and clinical electrocardiographic (ECG) signs ischemia.This a prospective superiority in 100 patients with chronic disease randomly allocated (1:1) RIMA vascular (verum group) or...
A 45-year-old sedentary office worker (187 cm, 117 kg, body mass index 34) gradually developed intolerance to physical exercise and suffered from general fatigue. He bought an electric bicycle commute work covered a total distance of 80 km per day five times week. In the next months, …
Our aim was to compare functional assessment of coronary stenosis severity by fractional flow reserve (FFR) measurement, as induced systemic adenosine, and regional reactive myocardial hyperaemia.The primary study endpoints were pressure-derived FFR values in response intravenous adenosine infusion (140 µg/min/kg), a one-minute proximal artery balloon occlusion (reactive hyperaemia) for the same interest. The secondary endpoint collateral index (CFI) during occlusion. CFI is ratio between...
Background: There is limited information on the prognostic impact of collateral circulation in patients with coronary artery disease (CAD). Apart from lack data relation between collaterals and survival, this due to complete unawareness whether such an association would be causal. Methods results: 1'181 stable CAD followed-up March 1996 April 2011 underwent a total 1'771 quantitative, pressure-derived flow index (CFI) measurements. 152 had been included randomized trials longitudinal effect...
Introduction In patients with chronic coronary syndrome, percutaneous intervention targets haemodynamically significant stenoses, that is, those thought to cause ischaemia. Intracoronary ECG (icECG) detects ischaemia directly where it occurs. Thus, the goal of this study was test accuracy icECG during pharmacological inotropic stress determine functional lesion severity in comparison structural parameter quantitative angiographic per cent diameter stenosis (%S), as well haemodynamic indices...
Arterial waves are seen as possible independent mediators of cardiovascular risks, and the wave intensity analysis (WIA) has therefore been proposed a method for patient selection ventricular assist device (VAD) implantation. Interpreting measured (WI) is challenging, complexity increased by implantation VAD. The generated VAD interact with native heart, this interaction varies changing settings. Eight sheep were implanted pulsatile (PVAD) through ventriculoaortic cannulation. start PVAD...
Abstract Objective To test the effect of long‐term pegfilgrastim on collateral function and myocardial ischaemia in patients with chronic stable coronary artery disease ( CAD ). Methods This was a prospective clinical trial randomized 2:1 allocation to or placebo for 6 months. The primary study endpoint flow index CFI ) as obtained during 1‐minute ostial balloon occlusion. is ratio mean occlusive divided by aortic pressure both subtracted central venous (mm Hg/mm Hg). Secondary endpoints...
namically significant PDA.Aortic stiffness index (ASI) was calculated from the following equation: ASI = (Systolic blood pressure/diastolic pressure)/((AoSD-AoDD)/AoDD) ×100 Results: Before PDA closure, significantly higher in children subgroup B than A (p value 0.001) and both subgroups (A B) controls, p <0.001.subgroup before after c P † Subgroup (n=23) Variables After closure <0.05 6.3±2.4 9.4±2.7 3.8±1.46.7±2.8Mean ± SD 58±2.5 52.6±2.2 66±4.2 59.4±5.3Mean LVEF,% 3.7±0.934.1±0.983±0.82...
This study tested the hypothesis that global physical activity and performance parameters are directly related to invasively obtained left superficial femoral artery (SFA) collateral flow index (CFI).So far, association between different measures of exercise quantitative lower limb function has not been investigated.The primary end point was pressure-derived CFI as during a 3 min SFA balloon occlusion. is ratio simultaneously recorded mean distal occlusive pressure divided by aortic...