A5041084808- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Acute Myocardial Infarction Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac Structural Anomalies and Repair
- Mechanical Circulatory Support Devices
- Cardiac pacing and defibrillation studies
- Aortic aneurysm repair treatments
- Peripheral Artery Disease Management
- Coronary Artery Anomalies
- Cerebrovascular and Carotid Artery Diseases
- Nitric Oxide and Endothelin Effects
- Infective Endocarditis Diagnosis and Management
- Tissue Engineering and Regenerative Medicine
- Venous Thromboembolism Diagnosis and Management
- Cardiac Fibrosis and Remodeling
- Cardiac Arrest and Resuscitation
- Vascular Procedures and Complications
- Heart Rate Variability and Autonomic Control
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Hemodynamic Monitoring and Therapy
University of Fribourg
2016-2025
Hirslanden Clinique Cecil
2008-2025
Fribourg Development Agency
2010-2023
University of Lausanne
2001-2023
Hôpital Nestlé
2012-2023
Réseau Fribourgeois de Santé Mentale
2022
Klinik Hirslanden
2022
University Medical Center
2020
HFR Freiburg Kantonsspital
2020
University Hospital of Bern
2004-2019
Stent thrombosis may occur late after drug-eluting stent (DES) implantation, and its cause remains unknown. The present study investigated differences of the stented segment between patients with without very use intravascular ultrasound.Since January 2004, presenting (> 1 year) DES implantation underwent ultrasound. Findings in were compared ultrasound routinely obtained 8 months 144 control patients, who did not experience for > or = 2 years. Very was encountered 13 at a mean 630+/-166...
Background Insulin resistance and arterial hypertension are related, but the underlying mechanism is unknown. Endothelial nitric oxide synthase (eNOS) expressed in skeletal muscle, where it may govern metabolic processes, vascular endothelium, regulates pressure. Methods Results To study role of eNOS control action insulin, we assessed insulin sensitivity conscious mice with disruption gene encoding for eNOS. −/− were hypertensive had fasting hyperinsulinemia, hyperlipidemia, a 40% lower...
Intravascular ultrasound of drug-eluting stent (DES) thrombosis (ST) reveals a high incidence incomplete apposition (ISA) and vessel remodeling. Autopsy specimens DES ST show delayed healing hypersensitivity reactions. The present study sought to correlate histopathology thrombus aspirates with intravascular findings in patients very late ST.The population consisted 54 (28 26 controls). Of 28 ST, 10 (1020+/-283 days after implantation) 11 segments (5 sirolimus-eluting stents, 5...
Pulmonary edema results from a persistent imbalance between forces that drive water into the air space and physiologic mechanisms remove it. Among latter, absorption of liquid driven by active alveolar transepithelial sodium transport has an important role; defect this mechanism may predispose patients to pulmonary edema. Beta-adrenergic agonists up-regulate clearance fluid attenuate in animal models.
Acute cardiogenic shock after myocardial infarction is associated with high in-hospital mortality attributable to persisting low-cardiac output. The Impella-EUROSHOCK-registry evaluates the safety and efficacy of Impella-2.5-percutaneous left-ventricular assist device in patients acute infarction.This multicenter registry retrospectively included 120 (63.6±12.2 years; 81.7% male) from receiving temporary circulatory support device. primary end point evaluated at 30 days. secondary analyzed...
Background— The prognostic relevance of the collateral circulation is still controversial. goal this study was to assess impact on survival quantitatively obtained, recruitable coronary flow in patients with stable artery disease during 10 years follow-up. Methods and Results— Eight-hundred forty-five individuals (age, 62±11 years), 106 without 739 chronic disease, underwent a total 1053 quantitative, pressure–derived measurements between March 1996 April 2006. All were prospectively...
Background— The pathomechanisms underlying very late stent thrombosis (VLST) after implantation of drug-eluting stents (DES) are incompletely understood. Using optical coherence tomography, we investigated potential causes this adverse event. Methods and Results— Between August 2010 December 2014, 64 patients were at the time point VLST as part an international tomography registry. Optical pullbacks performed restoration flow analyzed 0.4 mm. A total 38 early- 20 newer-generation suitable...
Biodegradable polymers for release of antiproliferative drugs from drug-eluting stents aim to improve vascular healing. We assessed noninferiority a novel ultrathin strut stent releasing sirolimus biodegradable polymer (Orsiro, O-SES) compared with the durable Xience Prime everolimus-eluting (X-EES) in terms primary end point in-stent late lumen loss at 9 months.A total 452 patients were randomly assigned 2:1 treatment O-SES (298 patients, 332 lesions) or X-EES (154 173 multicenter, trial....
Long-term comparative data of first-generation drug-eluting stents are scarce. We investigated clinical and angiographic outcomes sirolimus-eluting (SES) paclitaxel-eluting (PES) at 5 years as part the Sirolimus-Eluting Versus Paclitaxel-Eluting Stents for Coronary Revascularization (SIRTAX) LATE study.A total 1012 patients were randomly assigned to SES or PES. Repeat angiography was completed in 444 (43.8%) years. Major adverse cardiac events occurred 19.7% SES- 21.4% PES-treated (hazard...
Abstract Objective To show that limiting dual antiplatelet therapy (DAPT) to six months in patients with event-free ST-elevation myocardial infarction (STEMI) results a non-inferior clinical outcome versus DAPT for 12 months. Design Prospective, randomised, multicentre, non-inferiority trial. Setting Patients STEMI treated primary percutaneous coronary intervention (PCI) and second generation zotarolimus-eluting stent. Participants aged 18 85 underwent PCI the implantation of drug-eluting...
Background: Long-term trends of the incidence and outcome cardiogenic shock (CS) patients are scarce. We analyze for first time in CS during a 20-year period Switzerland. Methods Results: The AMIS (Acute Myocardial Infarction Switzerland) Plus Registry enrolls with acute myocardial infarction from 83 hospitals analyzed incidence, treatment, in-hospital mortality enrolled between 1997 2017. impact revascularization strategy on was assessed 2005 to Among 52 808 enrolled, 963 were excluded...
The metabolic syndrome comprises a clustering of cardiovascular risk factors but the underlying mechanism is not known. Mice with targeted disruption endothelial nitric oxide synthase (eNOS) are hypertensive and insulin resistant. We wondered, whether eNOS deficiency in mice associated phenotype mimicking human syndrome.In addition to arterial pressure sensitivity (euglycaemic hyperinsulinaemic clamp), we measured plasma concentration leptin, insulin, cholesterol, triglycerides, free fatty...
Context Individuals susceptible to high-altitude pulmonary edema (HAPE) are characterized by exaggerated hypertension and arterial hypoxemia at high altitude, but the underlying mechanism is incompletely understood.Anecdotal evidence suggests that shunting across a patent foramen ovale (PFO) may exacerbate in HAPE.Objective We hypothesized PFO more frequent HAPE-susceptible individuals contribute severe altitude.Design, Setting, Participants Case-control study of 16 participants 19...
Nitric oxide (NO) plays a major role in the regulation of cardiovascular and metabolic homeostasis, as evidenced by insulin resistance arterial hypertension endothelial NO synthase (eNOS) null mice. Extrapolation these findings to humans is difficult, however, because eNOS gene deficiency has not been reported. polymorphism impaired synthesis, have reported several disease states could predispose resistance. High-fat diet induces normal To test whether partial facilitates development during...