A5048050232- Coronary Interventions and Diagnostics
- Acute Myocardial Infarction Research
- Telomeres, Telomerase, and Senescence
- Cardiac Valve Diseases and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac Imaging and Diagnostics
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac Arrhythmias and Treatments
- Genetics, Aging, and Longevity in Model Organisms
- Heart Failure Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Renal cell carcinoma treatment
- Venous Thromboembolism Diagnosis and Management
- Bladder and Urothelial Cancer Treatments
- Cardiac Structural Anomalies and Repair
- Cardiac pacing and defibrillation studies
- Birth, Development, and Health
- Pericarditis and Cardiac Tamponade
- Cardiomyopathy and Myosin Studies
- Cardiac Health and Mental Health
- Vascular Procedures and Complications
- Lipoproteins and Cardiovascular Health
- Mesenchymal stem cell research
- Cardiac tumors and thrombi
- Takotsubo Cardiomyopathy and Associated Phenomena
Triemli Hospital
2015-2024
Stadtspital Waid
2020
Klinikum Stuttgart
2019
Advanced Memory Research Institute of New Jersey
2019
Fox Chase Cancer Center
2015
University Hospital of Basel
2005-2014
University of Zurich
2003-2014
University Hospital Innsbruck
2014
Elisabeth-Krankenhaus Essen
2014
Philadelphia University
2013
Senescence-associated (beta)-galactosidase is widely used as a biomarker of replicative senescence. However, it remains unknown whether this distinct enzyme active at pH 6, and differentially expressed in senescence, or manifestation an increase the classic acid lysosomal (beta)-galactosidase. Here we have investigated origin senescence-associated-(beta)-galactosidase activity by modifying intracellular young senescent human umbilical vein endothelial cells examining effect these...
Replicative senescence and oxidative stress have been implicated in ageing, endothelial dysfunction atherosclerosis. is determined primarily by telomere integrity. In cells the glutathione redox-cycle plays a predominant role detoxification of peroxides. The aim this study was to elucidate glutathione-dependent antioxidant system on replicative capacity dynamics cultured cells. Human umbilical vein were serially passaged while exposed regular treatment with 0.1 microM tert-butyl...
Abstract —The hypothesis that increased cellular proliferation in the vasculature may lead to replicative senescence has been tested a model of neointima formation. We have used biomarker senescence, senescence-associated β-galactosidase (SA-β-gal), detect rabbit carotid arteries subjected single and double balloon denudations. found an accumulation senescent cells media all injured vessels, contrast near absence such control vessels. The relative area occupied by SA-β-gal–positive was...
Background— Biodegradable-polymer drug-eluting stents (BP-DES) were developed to be as effective second-generation durable-polymer (DP-DES) and safe >1 year bare-metal (BMS). Thus, very late stent thrombosis (VLST) attributable durable polymers should no longer appear. Methods Results— To address these early aspects, 2291 patients presenting with acute or stable coronary disease needing ≥3.0 mm in diameter between April 2010 May 2012 randomly assigned biolimus-A9–eluting BP-DES,...
The aim of this study was to investigate the safety and efficacy biodegradable-polymer sirolimus-eluting stents (BP-SES) compared with durable-polymer everolimus-eluting (DP-EES) in patients ST-segment elevation myocardial infarction (STEMI). Primary percutaneous coronary intervention (PCI) is an effective treatment for STEMI, long-term outcomes are determined by profile newest generation drug-eluting stents. BIOSTEMI (A Comparison Ultrathin Strut Biodegradable Polymer Sirolimus-Eluting...
Local strategies directed against vascular smooth muscle cell (VSMC) proliferation such as drug-eluting stents reduce the occurrence of restenosis. However, these approaches may also inhibit endothelial (EC) and, thus, impair reendothelialization. We compared effects tacrolimus on human VSMC and EC migration to sirolimus, a compound with similar molecular structure. Thymidine incorporation was determined in growth factor-stimulated EC. The drug concentration at which maximal inhibited by 50%...
The mechanisms responsible for the age-related increase in incidence of calcific aortic valve stenosis (CAS) are unclear but may include telomere-driven cellular senescence. Because telomere length varies widely among individuals same age, we hypothesized that patients with shorter telomeres would be prone to develop CAS late life.Mean was measured leukocytes from a cohort 193 > or =70 years age and without CAS. Pilot experiments performed 30 controls pair-matched sex, presence absence...
Background No data are available on the long‐term performance of ultrathin strut biodegradable polymer sirolimus‐eluting stents ( BP ‐ SES ). We reported 2‐year clinical outcomes BIOSCIENCE (Ultrathin Strut Biodegradable Polymer Sirolimus‐Eluting Stent Versus Durable Everolimus‐Eluting for Percutaneous Coronary Revascularisation) trial, which compared with durable‐polymer everolimus‐eluting DP EES ) in patients undergoing percutaneous coronary intervention. Methods and Results A total 2119...
Women with ST-segment elevation myocardial infarction (STEMI) experience greater delays for percutaneous coronary intervention-facilitated reperfusion than men. Whether women and men benefit equally from current strategies to reduce ischaemic time whether there are gender differences in factors determining is unclear.Patient delay (symptom onset first medical contact) system (first contact reperfusion) were compared between ( n=967) n=3393) a Swiss STEMI treatment network. Trends 2000 2016...
Objective— Telomerase plays a major role in the control of replicative capacity, critical property for successful angiogenesis and maintenance endothelial integrity. In this study, we examined relationship between telomerase activity cell proliferation as well regulation enzyme by fibroblast growth factor-2 (FGF-2) vascular factor-A (VEGF). Methods Results— was repressed cells freshly derived from intact endothelium, whereas present during logarithmic culture. cultured human umbilical vein...
About 30% of patients develop AF after open heart surgery. Biatrial synchronous pacing (BSP) has been shown to promote sinus rhythm in with paroxysmal refractory drug therapy. We conducted a prospective, randomized study test the effect BSP via epicardial electrodes on incidence surgery, as compared conventional To apply BSP, we attached two right and one left atrium. Immediately following was initiated AAI‐Mode at rate 10 beats/min above underlying (maximum 110 beats/min) continued for 3...
Cardiac hypertrophic stimuli induce both adaptive and maladaptive growth response pathways in heart. Here we show that mice lacking junD develop less hypertrophy heart after mechanical pressure overload, while cardiomyocyte-specific expression of results spontaneous ventricular dilation decreased contractility. In contrast, fra-1 conditional knock-out have a normal response, whereas hearts from transgenic decompensate prematurely. Moreover, simultaneously reveal dilated cardiomyopathy...
<h3>Background:</h3> Early risk stratification is important in the management of patients with acute coronary syndromes (ACS). <h3>Objective:</h3> To develop a rapidly available tool for use all ACS. <h3>Design and methods:</h3> Application modern data mining machine learning algorithms to derivation cohort 7520 ACS included AMIS (Acute Myocardial Infarction Switzerland)-Plus registry between 2001 2005; prospective model testing two validation cohorts. <h3>Results:</h3> The most accurate...
Aims Large randomized trials comparing DDD with VVI pacing have shown no differences in mortality, but conflicting evidence exists regard to heart failure endpoints. Here we evaluated the effect of mode on serum levels brain natriuretic peptide (BNP) and amino-terminal-proBNP (NT-proBNP).
The British National Institute of Clinical Excellence (NICE) guidelines recommend to use drug-eluting stents (DES) instead bare-metal (BMS) only in lesions >15 mm length or vessels <3 diameter. We analyzed the impact stent and diameter on in-stent restenosis (ISR) BASKET-PROVE study population evaluated cost-effectiveness DES compared BMS.The trial vs BMS large coronary arteries (≥3 mm). calculated incremental ratios (ICERs) acceptability curves with regard quality-adjusted life years...
A bstract : In cultured human umbilical vein endothelial cells (HUVECs), fibroblast growth factor‐2 (FGF‐2), but not vascular factor‐A (VEGF‐A), upregulates telomerase activity. Here, we examined the functional significance of this differential regulation on replicative life span HUVECs. HUVECs were serially passaged until senescence under four different conditions: (1) EGM‐2, a medium containing both VEGF‐A and FGF‐2; (2) basal (BM), consisting EGM‐2 devoid FGF‐2 VEGF‐A; (3) BM supplemented...
The purpose of this study was to investigate outcomes patients treated with prasugrel or clopidogrel after percutaneous coronary intervention (PCI) in a nationwide acute syndrome (ACS) registry. Prasugrel found be superior randomized trial ACS undergoing PCI. However, little is known about its efficacy everyday practice. All enrolled the Acute Myocardial Infarction Switzerland (AMIS)-Plus registry PCI and being thienopyridine P2Y12 inhibitor between January 2010–December 2013 were included...