A5065666991- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Function and Risk Factors
- Pulmonary Hypertension Research and Treatments
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Advanced MRI Techniques and Applications
- Cardiac Valve Diseases and Treatments
- Viral Infections and Immunology Research
- Cardiovascular and Diving-Related Complications
- Kawasaki Disease and Coronary Complications
- Elasticity and Material Modeling
- SARS-CoV-2 and COVID-19 Research
- Peripheral Artery Disease Management
- Coronary Artery Anomalies
- Cardiac electrophysiology and arrhythmias
- Atherosclerosis and Cardiovascular Diseases
- Renal and Vascular Pathologies
- Medication Adherence and Compliance
- Transplantation: Methods and Outcomes
- Cardiovascular Issues in Pregnancy
Northside Hospital
2021-2024
Emory University
2011-2020
Jacobi Medical Center
2013-2017
University of British Columbia
2017
NewYork–Presbyterian Hospital
2017
Cornell University
2017
Emory University Hospital
2016
Montefiore Medical Center
2014-2016
Emory Clinic
2016
Yonsei University
2016
Background Experimental studies suggest that low wall shear stress (WSS) promotes plaque development and high WSS is associated with destabilization. We hypothesized low-WSS segments in patients coronary artery disease develop progression high-WSS necrotic core fibrous tissue regression. Methods Results Twenty underwent baseline 6-month radiofrequency intravascular ultrasound (virtual histology ultrasound) computational fluid dynamics modeling for calculation. For each virtual segment...
Intravascular ultrasound of drug-eluting stent (DES) thrombosis (ST) reveals a high incidence incomplete apposition (ISA) and vessel remodeling. Autopsy specimens DES ST show delayed healing hypersensitivity reactions. The present study sought to correlate histopathology thrombus aspirates with intravascular findings in patients very late ST.The population consisted 54 (28 26 controls). Of 28 ST, 10 (1020+/-283 days after implantation) 11 segments (5 sirolimus-eluting stents, 5...
In this study, we aimed to characterize the clinical presentation, short-term prognosis, and myocardial tissue changes as noted on cardiovascular magnetic resonance (CMR) or cardiac MRI in pediatric patients with coronavirus disease 2019 vaccination-associated myocarditis (C-VAM).In retrospective multicenter study across 16 US hospitals, <21 years of age a diagnosis C-VAM were included compared cohort multisystem inflammatory syndrome children. Younger children older adolescents.Sixty-three...
Extremes of wall shear stress (WSS) have been associated with plaque progression and transformation, which has raised interest in the clinical assessment WSS. We hypothesized that calculated coronary WSS is predicted only partially by luminal geometry related to composition.Twenty-seven patients artery disease underwent virtual histology intravascular ultrasound Doppler velocity measurement for computational fluid dynamics modeling calculation each segment (N=3581 segments). assessed...
Late acquired incomplete stent apposition (ISA) is more common after drug-eluting (DES) than bare metal (BMS) implantation and has been associated with vascular hypersensitivity thrombosis (ST). We investigated the impact of incidentally discovered ISA as assessed by intravascular ultrasound (IVUS) 8 months DES on long-term clinical outcome. A total 194 patients 221 lesions were prospectively followed through 5 years. At months, IVUS showed evidence among 37 39 (18%) (mean ISAmax 4.7 ± 5.0...
Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this relationship has not been examined in human atherosclerosis progression. Thus, the aim of investigation was examine association between WSS, combination with WSS magnitude, coronary We hypothesized regions will demonstrate progression towards lesions, while exposed non-oscillatory exhibit stable lesions. Patients ( n = 20)...
Background— Patients with obstructive (≥50% stenosis) left main (LM) coronary artery disease (CAD) are at high risk for adverse events; prior studies have also documented worse outcomes among women than men severe multivessel/LM CAD. However, the prognostic significance of nonobstructive (1%–49% LM CAD, including sex-specific differences, has not been previously examined. Methods and Results— In long-term CONFIRM (Coronary CT Angiography Evaluation For Clinical Outcomes: An International...
Aims: Local wall shear stress (WSS) plays an important role in the onset of atherosclerotic plaque formation; however, it does not fully explain progression and destabilisation. We aimed to investigate for first time influence multidirectional WSS features on composition changes human coronary arteries. Methods results: Coronary artery imaging using biplane angiography virtual histology intravascular ultrasound (VH-IVUS) was performed twenty patients with disease at baseline after six-month...