A5078539679- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Aortic aneurysm repair treatments
- Cerebrovascular and Carotid Artery Diseases
- Acute Myocardial Infarction Research
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Cardiovascular Health and Disease Prevention
- Peripheral Artery Disease Management
- Cardiac Valve Diseases and Treatments
- Elasticity and Material Modeling
- Optical Coherence Tomography Applications
- Vascular Procedures and Complications
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced X-ray and CT Imaging
- Hemodynamic Monitoring and Therapy
- Aortic Thrombus and Embolism
- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Textile materials and evaluations
- Non-Destructive Testing Techniques
- Brain Tumor Detection and Classification
- Infrared Thermography in Medicine
- Ion channel regulation and function
- Retinal Imaging and Analysis
Emory University
2013-2023
Southeast Georgia Health System
2022-2023
Northeast Georgia Medical Center
2021-2023
Gainesville Obstetrics & Gynecology
2023
Emory University Hospital
2020-2022
Monash University
2021
The Wallace H. Coulter Department of Biomedical Engineering
2013-2019
Georgia Institute of Technology
2012-2019
Southeast University
2017
Worcester Polytechnic Institute
2017
Although experimental studies suggest that low and oscillatory wall shear stress (WSS) promotes plaque transformation to a more vulnerable phenotype, this relationship has not been examined in human atherosclerosis progression. Thus, the aim of investigation was examine association between WSS, combination with WSS magnitude, coronary We hypothesized regions will demonstrate progression towards lesions, while exposed non-oscillatory exhibit stable lesions. Patients ( n = 20)...
Abstract Aims The focal distribution of atherosclerotic plaques suggests that local biomechanical factors may influence plaque development. Methods and results We studied 40 patients at baseline over 12 months by virtual-histology intravascular ultrasound bi-plane coronary angiography. calculated structural stress (PSS), defined as the mean maximum principal peri-luminal region, wall shear (WSS), parallel frictional force exerted blood flow on endothelial surface, in areas undergoing...
Abstract Background Abdominal aortic aneurysms (AAA) are local dilatations of the infrarenal aorta. If left untreated they may rupture and lead to death. One form treatment is minimally invasive insertion a stent-graft into aneurysm. Despite this effective occasionally continue expand eventually result in post-operative Fluid-structure interaction (FSI) particularly useful tool for investigating aneurysm biomechanics as both wall stresses fluid forces can be examined. Methods Pre-op, Post-op...
Aims: Local wall shear stress (WSS) plays an important role in the onset of atherosclerotic plaque formation; however, it does not fully explain progression and destabilisation. We aimed to investigate for first time influence multidirectional WSS features on composition changes human coronary arteries. Methods results: Coronary artery imaging using biplane angiography virtual histology intravascular ultrasound (VH-IVUS) was performed twenty patients with disease at baseline after six-month...
To compare the function of 2 stent-graft designs for endovascular abdominal aortic aneurysm repair.Computational fluid dynamics was used to investigate performance a conventional versus one with novel tapered configuration (equal area ratios at inlet and bifurcation). Idealized geometries (uniplanar) were formed first both devices. mimic clinical setting pulsatile blood flow, realistic model (multiplanar) created based on computed tomography scans from 3 patients different geometries. A...
Background We hypothesized that nebivolol, a β‐blocker with nitric oxide–mediated activity, compared atenolol, without such would decrease oxidative stress and improve the effects of endothelial dysfunction wall shear ( WSS ), thereby reducing atherosclerosis progression vulnerability in patients nonobstructive coronary artery disease. Methods Results In this pilot double‐blinded randomized controlled trial, 24 treated for 1 year nebivolol 10 mg versus atenolol 100 plus standard medical...
Accurate cap thickness and stress/strain quantifications are of fundamental importance for vulnerable plaque research. Virtual histology intravascular ultrasound (VH-IVUS) sets to zero when is under resolution limit IVUS does not see it. An innovative modeling approach combining optical coherence tomography (OCT) introduced quantification more accurate calculations. In vivo OCT coronary data were acquired with informed consent obtained. images merged form the + set, biplane angiography...
Wall shear stress (WSS) has been associated with sites of plaque localization and changes in composition human coronary arteries. Different values have suggested for categorizing WSS as low, physiologic or high; however, uncertainties flow rates, both across subjects within a given individual, can affect the classification thus influence observed relationships between local hemodynamics over time. This study examines effects rate boundary conditions upon investigates this variability on...
Accurate cap thickness quantification is of fundamental importance for vulnerable plaque detection in cardiovascular research. A segmentation method intracoronary optical coherence tomography (OCT) image based on least squares support vector machine (LS-SVM) was performed to characterize component borders and quantify fibrous thickness. Manual OCT images were by experts combination virtual-histology intravascular ultrasound (VH-IVUS) used as gold standard. The methods LS-SVM provided...
Optical coherence tomography (OCT) is a new intravascular imaging technique with high resolution and could provide accurate morphological information for plaques in coronary arteries. However, its segmentation still co... | Find, read cite all the research you need on Tech Science Press