A5079396922- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Lymphatic System and Diseases
- Circadian rhythm and melatonin
- Angiogenesis and VEGF in Cancer
- Acute Myocardial Infarction Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Systemic Sclerosis and Related Diseases
- Dietary Effects on Health
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Disease and Adiposity
- Garlic and Onion Studies
- Cancer-related Molecular Pathways
- Cardiac Ischemia and Reperfusion
- Congenital heart defects research
- Sleep and Wakefulness Research
- Cardiovascular Health and Disease Prevention
- Transplantation: Methods and Outcomes
- Ubiquitin and proteasome pathways
- Medical and Biological Ozone Research
- RNA Research and Splicing
Nagoya University
2020-2024
Harbin Medical University
2016-2021
Brigham and Women's Hospital
2020-2021
Second Affiliated Hospital of Harbin Medical University
2016-2021
Harvard University
2020
Mayo Clinic in Arizona
2020
MiRNA expression was determined in both proliferating and differentiated cardiac stem cells (CSCs) through a comprehensive miRNA microarray analysis. We selected miR218 for functional follow-up studies to examine its significance CSCs. First, we observed that the of altered CSCs during differentiation into cardiomyocytes, transfection an mimic or inhibitor affected myocardial Furthermore, negative regulator Wnt signaling, sFRP2, direct target miR218, protein levels sFRP2 were increased...
Background Circadian rhythm disorders, often seen in modern lifestyles, are a major social health concern. The aim of this study was to examine whether circadian disorders would influence angiogenesis and blood perfusion recovery mouse model hind limb ischemia. Methods Results A jet-lag established C57BL/6J mice using light-controlled isolation box. Control were kept at light/dark 12:12 (12-hour light 12-hour dark) condition. Concentrations plasma vascular endothelial growth factor...
Emerging evidence has documented that circadian rhythm disorders could be related to cardiovascular diseases. However, there is limited knowledge on the direct adverse effects of misalignment heart. This study aimed investigate effect chronic disorder heart homeostasis in a mouse model consistent jetlag. The jetlag was induced mice by serial 8-h phase advance light cycle using light-controlled isolation box every 4 days for up 3 months. Herein, we demonstrated first time established lead...
Although cardiac lymphatic vessels have received increasing attention in recent years, there is still a knowledge gap between lymphatics and heart homeostasis normal heart. In the present study, we established mouse model of insufficiency ablating collector to reveal crucial role maintaining impact on function both physiological pathologic settings. Furthermore, therapeutic lymphangiogenesis improved adverse effect morphologic changes functions. These findings suggest that system would be...
MicroRNAs (miRNAs) have emerged as crucial factors that regulate proliferation and apoptosis of cardiac c-kit+ cells. Although much is known about their role in maintaining cell pluripotency, the mechanisms by which they affect fate decisions are an essential part repair heart failure remain poorly understood. Cardiac cells were obtained from Balb/c mice cultured vitro. Lentiviral vectors miR199a-3p, its corresponding anti-miRNA, or short hairpin RNA against Cables1 transfected into The was...
Background Accumulating evidence suggests that hydrogen sulfide ( H2S ), an endogenously produced gaseous molecule, plays a critical role in the regulation of cardiovascular homeostasis. However, little is known about its lymphangiogenesis. Thus, current study aimed to investigate involvement lymphatic vessel growth and lymphedema resolution using murine model assess underlying mechanisms. Methods Results A tail was created both wild-type mice cystathionine γ-lyase-knockout mice, evaluate up...
Objective: Lymphatic vessels are distributed throughout the body and tightly collaborate with blood to maintain tissue homeostasis. However, functional roles of lymphangiogenesis in process reparative angiogenesis ischemic tissues largely unknown. Accordingly, we investigated potential using a mouse model ischemia-induced angiogenesis. Approach Results: Male C57BL/6J mice were subjected unilateral hindlimb ischemia, which not only but also was induced. Next, excessive prolonged edema...
Therapeutic angiogenesis with autologous stem/progenitor cells is a promising novel strategy for treatment of severe ischemic diseases. Human clinical trials utilizing adipose-derived regenerative (ADRCs) have not reported treatment-related critical adverse effects thus far. However, there still large knowledge gap regarding whether diseases angiogenic therapy using ADRCs would promote unfavorable associated tumors in vivo. Herein, we addressed this question mouse hindlimb ischemia (HLI) and...
Cables1 (Cdk5 and Abl enzyme substrate 1) is a vital cell cycle regulator candidate tumor suppressor that negatively regulates growth by inhibiting cyclin-dependent kinases. Here, we report on the critical role of Cables1/p21 pathway, which inhibits proliferation induces senescence in human umbilical vein endothelial cells. Moreover, confirmed silencing promoted as well increased resistance to angiotensin II-induced senescence, at least part, altering activation. We further demonstrated...
Coronary angiography (CAG) is widely used to assess lumen dimensions, and optical coherence tomography (OCT) evaluate the characteristics of atherosclerotic plaque. This study was aimed compare coronary dimensions using CAG plaque OCT their changes during statin therapy. We identified 97 lipid-rich plaques from 69 statin-naïve patients, who received therapy in following 12 months. examinations were conducted at baseline 12-month follow-up period. Lesion length, as measured by CAG, closely...
An amendment to this paper has been published and can be accessed via a link at the top of paper.
Introduction: Risk-stratification of individual coronary plaques is an important goal to detect high-risk likely progress/destabilize, which could inform preemptive intervention prevent adverse cardiac events. IVUS imaging, the current gold standard assess plaque risk, has shown that biomechanical variables, particularly local ESS, contributes critical synergistic prognostic insight when combined with anatomic features. Non-invasive risk assessment CCTA would be invaluable enable broad...
Introduction: The role of endothelial shear stress (ESS) in the development coronary plaque erosion is unknown. High ESS gradient (ESSG) has been hypothesized to promote erosion, but no studies have included matched control stable plaques with same minimal and reference lumen area (MLA, RLA, respectively). No examined location (proximal vs distal MLA culprit plaque) related max magnitude upslope downslope obstruction. Aims: (1) compare ESSG between similar that remained stable; (2) among...
Background: Ischemia and reperfusion (I/R) injury induces intracellular calcium overload generation of reactive oxygen species, which trigger mitochondrial damage, resulting in cardiomyocyte apoptosis. Freshly prepared autologous mitochondria improved damaged cardiac function, however, little is known whether allogenic organelle complex -Q (MRC-Q) can be replenished the heart to achieve cardioprotective effects against I/R injury. Purpose: The aim this study was investigate exogenous...
Background: Although clock genes generate oscillations in about 10 % of all gene expressions as a 24-hour cycle the cellular level cooperating with central clock, little is known role angiogenesis. Objective: The aim this study was to determine if peripheral would modulate angiogenesis hind limb ischemia (HLI) model. Methods and Results: First, we surgically induced HLI model C57BL/6J (wild type; WT) mice (N=6 for each time point) checked mRNA local ischemic tissue by PCR array setting blood...
Introduction: The role of endothelial shear stress (ESS) in the natural history plaque growth and TCFA formation/destabilization has been studied, but erosion is unknown. High ESS gradient (ESSG) hypothesized to promote erosion, no studies have included matched “control” stable plaques with same minimal luminal area (MLA) reference (RLA) adverse coronary event. Hypothesis: To compare ESSG between that developed similar morphology remain stable. Methods: We studied a subset patients from both...