A5073738404- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- Cardiovascular Disease and Adiposity
- Cerebrovascular and Carotid Artery Diseases
- Atherosclerosis and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Pluripotent Stem Cells Research
- Estrogen and related hormone effects
- Hormonal and reproductive studies
- Sperm and Testicular Function
- HIV Research and Treatment
- CRISPR and Genetic Engineering
- Blood groups and transfusion
- Viral Infections and Immunology Research
- RNA Research and Splicing
- Glaucoma and retinal disorders
- Plant-based Medicinal Research
- Transplantation: Methods and Outcomes
- Ocular Infections and Treatments
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Heat shock proteins research
- RNA modifications and cancer
- Ultrasound and Hyperthermia Applications
- Lung Cancer Treatments and Mutations
Brigham and Women's Hospital
2020-2023
Harvard University
2020-2023
Northeastern University
2021
Mayo Clinic in Arizona
2020
Université de Moncton
2017
Atlantic Cancer Research Institute
2017
University of Ottawa
1996-1998
Ottawa Regional Cancer Foundation
1996-1998
Ottawa Hospital
1997
To assess dried plasma spots (DPSs) as a source of material for virus quantification, human immunodeficiency type 1 (HIV-1) RNA levels were quantified in matched DPS and liquid samples from 73 infected patients, including 5 neonates 4 adult patients with acute HIV-1 infection. Quantifications performed by commercially available assays (NASBA [nucleic acid sequence-based amplification] or Amplicor, both). There was strong correlation between DPSs. More importantly, there no decline DPSs...
The complexity of human tissue fluid precludes timely identification cancer biomarkers by immunoassay or mass spectrometry. An increasingly attractive strategy is to primarily enrich extracellular vesicles (EVs) released from cells in an accelerated manner compared normal cells. Vn96 peptide was herein employed recover a subset EVs into the media cellular models breast cancer. has affinity for heat shock proteins (HSPs) decorating surface EVs. Reflecting their origin, displayed discrete...
Introduction: Plaque natural history is related to local shear stress, and stress has been shown be heterogeneously distributed along the length of individual plaques. We investigated longitudinal spatial heterogeneity plaque progression/regression/quiescence in human coronary arteries. Methods: 591 arteries from 302 patients with disease who presented an acute syndrome PREDICTION study were for patterns non-culprit plaques after 6-10 month FU. Arterial geometry was derived...
Objective: Accelerated atherosclerosis in diabetes constitutes an ongoing challenge despite optimal medical therapies. This study aimed to identify evolutionarily conserved lesion-based regulatory signaling networks diabetic versus nondiabetic conditions during the development of initial translational effort provide insights for targets. Approach and Results: Serial 3-mm coronary artery segments hypercholesterolemic Yorkshire swine diabetic-hypercholesterolemic were characterized as mild,...
Introduction: Risk-stratification of individual coronary plaques is an important goal to detect high-risk likely progress/destabilize, which could inform preemptive intervention prevent adverse cardiac events. IVUS imaging, the current gold standard assess plaque risk, has shown that biomechanical variables, particularly local ESS, contributes critical synergistic prognostic insight when combined with anatomic features. Non-invasive risk assessment CCTA would be invaluable enable broad...
Abstract Background Patterns of local endothelial shear stress (ESS) are heterogeneous along the course individual coronary artery plaques. It is unknown how this heterogeneity affects natural history plaque burden (PB) over time. Objectives To determine effect ESS patterns plaques at baseline on subsequent PB progression, regression, and quiescence in human arteries its link to clinical events. Methods 302 patients from PREDICTION study were included study. The was an anatomic followup...
ALX40-4C is an antiretrovirus agent that has been found to have some inhibitory properties against human immunodeficiency virus (HIV) replication in vitro. The compound was designed as a competitor of the HIV Tat protein for TAR binding. In addition its anti-HIV properties, it demonstrated ability inhibit vitro herpes simplex types 1 and 2 well cytomegalovirus. Subsequently, vivo pharmacokinetic evaluation necessitated establishment detection system measurement subject serum. For this...
Introduction: The role of endothelial shear stress (ESS) in the natural history plaque growth and TCFA formation/destabilization has been studied, but erosion is unknown. High ESS gradient (ESSG) hypothesized to promote erosion, no studies have included matched “control” stable plaques with same minimal luminal area (MLA) reference (RLA) adverse coronary event. Hypothesis: To compare ESSG between that developed similar morphology remain stable. Methods: We studied a subset patients from both...
Abstract Background Atherosclerosis manifests itself differently in women compared to men. Since the pathophysiology of atherosclerotic plaques is known be related endothelial shear stress (ESS), it was hypothesized that female male coronary arteries demonstrate a different i) ESS and ii) plaque progression. Methods 1183 (male/female:944/239) from PREDICTION trial were studied for differences vessel geometry (plaque area (PA) lumen (LA)), hemodynamic parameters (flow, minimal over 90 degree...
Abstract Background The natural history of plaque growth is, among other systemic risk factors, related to the blood flow induced local shear stress. Especially at regions low stress plaques are initiated. Upon encroachment into lumen, will be exposed high Interestingly, it has been observed that individual very heterogeneous regarding exposure and remodeling patterns along length. However no information is available on spatial heterogeneity temporal changes in burden. We studied...