A5077764635- Glycosylation and Glycoproteins Research
- Metabolomics and Mass Spectrometry Studies
- Carbohydrate Chemistry and Synthesis
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Bee Products Chemical Analysis
- Phytochemicals and Antioxidant Activities
- Insect and Pesticide Research
- Synthesis and Biological Evaluation
- Estrogen and related hormone effects
- Synthesis and biological activity
- Sperm and Testicular Function
- Sphingolipid Metabolism and Signaling
- Hormonal and reproductive studies
- Plant biochemistry and biosynthesis
- Chemical Synthesis and Analysis
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- Biochemical Acid Research Studies
- Sirtuins and Resveratrol in Medicine
- Antioxidant Activity and Oxidative Stress
- Genomics, phytochemicals, and oxidative stress
- Chemistry and Chemical Engineering
Université de Moncton
2016-2025
Tunis University
2021
Institut Universitaire de Cardiologie et de Pneumologie de Québec
2018
Université du Québec à Montréal
2006-2017
Moncton Hospital
2016
Département de Chimie Moléculaire
2015-2016
Université Paris Cité
2005-2007
Délégation Paris 7
2007
Laboratoire d'Electrochimie Moléculaire
2005-2007
Pentaerythritol and bis-pentaerythritol scaffolds were used for the preparation of first generation glycodendrimers bearing aryl alpha-D-mannopyranoside residues assembled using single-step Sonogashira click chemistry. The carbohydrate precursors built with either para-iodophenyl, propargyl, or 2-azidoethyl aglycones whereas pentaerythritol moieties terminal azide propargyl groups, respectively. Cross-linking abilities this series evaluated lectin from Canavalia ensiformis (Concanavalin A)....
Uropathogenic Escherichia coli (UPEC) are the major causative agents of urinary tract infections. During infection, UPEC adhere to mannosylated glycoreceptors on urothelium via FimH adhesin located at tip type 1 pili. Synthetic antiadhesives such as alkyl and phenyl α-D-mannopyranosides thus ideal candidates for chemical interception this crucial step in pathogenesis. The crystal structures lectin domain its ligand-free form complexes with eight medium- high-affinity mannopyranoside...
Background 5-lipoxygenase (5-LO) catalyses the transformation of arachidonic acid (AA) into leukotrienes (LTs), which are important lipid mediators inflammation. LTs have been directly implicated in inflammatory diseases like asthma, atherosclerosis and rheumatoid arthritis; therefore inhibition LT biosynthesis is a strategy for treatment these chronic diseases. Methodology/Principal Findings Analogues caffeic acid, including naturally-occurring phenethyl ester (CAPE), were synthesized...
Autotaxin (ATX) is an adipokine that generates the bioactive lipid, lysophosphatidic acid (LPA). ATX-LPA signaling has been implicated in diet-induced obesity and systemic insulin resistance. However, it remains unclear whether pathway influences function energy metabolism target tissues, particularly skeletal muscle, major site of insulin-stimulated glucose disposal. The objective this study was to test impacts tissue mitochondrial muscle during obesity. Male mice with heterozygous ATX...
Caffeic acid phenethyl ester (CAPE) is a bioactive component isolated from propolis. A series of CAPE analogues was synthesized and their antiradical/antioxidant effects analyzed. The effect the presence double bond conjugated system on antioxidant evaluated with obtained 3-(3,4-dihydroxyphenyl) propanoic acid. Those 2-(3,4-dihydroxyphenyl) acetic 3,4-dihydroxybenzoic allow evaluation two carbons between carbonyl aromatic system.
Pinane, obtained by catalytic hydrogenation of α/β-pinenes or turpentine oil, was used as an alternative solvent for the extraction several bioactive compounds.
Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds structure-activity optimization Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation genes involved oxidative stress response downregulation DNA replication leading to G2/M arrest subsequent apoptosis induction. In accordance with this,...
Anaplastic Large Cell Lymphoma (ALCL) is an aggressive T-cell lymphoma affecting children and young adults. About 30% of patients develop therapy resistance therefore new precision medicine drugs are highly warranted. Multiple rounds structure-activity optimization Caffeic Acid Phenethyl Ester have resulted in CM14. CM14 causes upregulation genes involved oxidative stress response downregulation DNA replication leading to G2/M arrest subsequent apoptosis induction. In accordance with this,...
Several oligomannoside clusters having a hundred-fold increase in affinities toward E. coli were synthesized by Cu(I)-catalyzed [1,3]-dipolar cycloadditions using pentaerythritol scaffolds bearing either alkyne or azide functionalities.
A short and efficient strategy for the first synthesis of "Majoral-Type" multivalent glycodendrimers bearing covalently bound alpha-D-mannopyranosides onto a cyclotriphosphazene scaffold assembled using single-step Sonogashira click chemistry is reported. New glycoclusters with valencies ranging from 6 to 18 different epitope spatial arrangements were obtained. Cross-linking abilities this series evaluated model lectin Canavalia ensiformis (Concanavalin A). The decameric mannoside 23, built...
Antagonists of the FimH adhesin, a protein almost universally present at extremity type-1 fimbriae expressed by Escherichia coli, have been abundantly in spotlight as alternative treatments urinary tract infections. The antagonists function bacterial antiadhesives through highly specific α-d-mannose binding charged and polar pocket tip lectin domain stacking alkyl or aromatic moieties substituted on mannose with two tyrosine residues (Tyr48 Tyr137) entrance mannose-binding pocket. Using...
Solvent-free catalytic hydrogenation of pinene over Pd on carbon, alumina, and silica supports were compared. Despite the absence solvent, catalyst all three yields to a quantitative conversion pinanes higher selectivity for cis isomer (72–89%). The temperature affected similarly reaction catalysts in favor cis-pinane isomer. However, recycling tested varied greatly. If Pd/C Pd/alumina successfully recycled 13 14 times, respectively, Pd/silica could be used only once convert pinenes into...
Androgen production primarily occurs in Leydig cells located the interstitial compartment of testis. In aging males, testosterone is crucial for maintaining muscle mass and strength, bone density, sexual function, metabolic health, energy levels, cognitive as well overall well-being. As men age, by testes begins to decline at a rate approximately 1% per year starting from their 30s. This review highlights recent findings concerning use natural polyphenolics compounds, such flavonoids,...