A5086905123- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Coronary Interventions and Diagnostics
- Congenital heart defects research
- Tissue Engineering and Regenerative Medicine
- Cardiac Fibrosis and Remodeling
- Adipokines, Inflammation, and Metabolic Diseases
- Cardiac electrophysiology and arrhythmias
- Cardiac Structural Anomalies and Repair
- Sarcoidosis and Beryllium Toxicity Research
- Adipose Tissue and Metabolism
- Cardiovascular Disease and Adiposity
- Angiogenesis and VEGF in Cancer
- Cardiac Arrhythmias and Treatments
- Advanced MRI Techniques and Applications
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Advanced X-ray and CT Imaging
- S100 Proteins and Annexins
- Mesenchymal stem cell research
- Hormonal Regulation and Hypertension
- Elasticity and Material Modeling
Nagoya University
2013-2024
Japanese Red Cross Nagoya Daini Hospital
2003-2024
Sakakibara Hospital
2023
Weatherford College
2023
Brigham and Women's Hospital
2012-2019
Harvard University
2012-2019
Nagoya University Hospital
2019
Cardiovascular Institute of the South
2013
Stanford University
2013
University of Crete
2012
In response to injury, the rodent heart is capable of virtually full regeneration via cardiomyocyte proliferation early in life. This regenerative capacity, however, diminished as 1 week postnatal and remains lost adulthood. The mechanisms that dictate postinjury life remain unclear.To delineate role miR-34a, a regulator age-associated physiology, regulating cardiac secondary myocardial infarction (MI) neonatal adult mouse hearts.Cardiac injury was induced hearts through experimental MI...
Rationale: Physical exercise provides benefits for various organ systems, and some of systemic effects are mediated through modulation muscle-derived secreted factors, also known as myokines. Myonectin/C1q (complement component 1q)/TNF (tumor necrosis factor)-related protein 15/erythroferrone is a myokine that upregulated in skeletal muscle blood by exercise. Objective: We investigated the role myonectin myocardial ischemic injury. Methods Results: Ischemia-reperfusion myonectin-knockout...
Multiple progenitors derived from the heart and bone marrow (BM) have been used for cardiac repair. Despite this, not much is known about molecular identity relationship among these progenitors. To develop a robust stem cell therapy heart, it critical to understand of multiple cardiogenic progenitor cells.This study first report high-throughput transcriptional profiling cells carried out on an identical platform.Microarray-based was 3 (ckit(+), Sca1(+), side population) 2 BM (ckit(+)...
Adiponectin plays a protective role in the development of obesity-linked disorders. We demonstrated that adiponectin exerts beneficial actions on acute ischemic injury mice hearts. However, effects treatment large animals and its feasibility clinical practice have not been investigated. This study investigated intracoronary administration myocardial ischemia-reperfusion (I/R) pigs.The left anterior descending coronary artery was occluded pigs for 45 minutes then reperfused 24 hours....
Background Exposure to chronic psychosocial stress is a risk factor for atherosclerosis‐based cardiovascular disease. We previously demonstrated the increased expressions of cathepsin S (CatS) in atherosclerotic lesions. Whether CatS participates directly stress‐related neointimal hyperplasia has been unknown. Methods and Results Male wild‐type CatS‐deficient mice that underwent carotid ligation injury were subjected immobilization morphological biochemical studies at specific times. On day...
Hydrogen sulfide (H2S) exerts beneficial actions against the development of cardiovascular disease. Diallyl trisulfide (DATS) is an organic polysulfide found in garlic oil that liberates H2S under physiological conditions. This study investigated whether DATS modulates endothelial cell function, as well revascularization processes a mouse model hind-limb ischemia.Methods and Results:Wild-type (WT), nitric oxide synthase-deficient (eNOS-KO) Akt1-heterogenic deficient (Akt-Het) mice were...
Abstract Adipose-derived regenerative cell (ADRC) is a promising alternative source of autologous somatic stem cells for the repair damaged tissue. This study aimed to assess safety and feasibility ADRC implantation therapeutic angiogenesis in patients with critical limb ischaemia (CLI). A clinical pilot study—Therapeutic Angiogenesis by Cell Transplantation using ADRCs (TACT-ADRC) study—was initiated Japan. Adipose tissue was obtained ordinary liposuction method. Isolated were injected into...
AimsTo examine the relation between mitochondrial dysfunction and myocardial contractile relaxation reserves in hypertrophic cardiomyopathy (HCM).
The favorable effects of the peroxisome proliferator-activated receptor-gamma ligand pioglitazone on glucose metabolism are associated with an increase in fat-derived hormone adiponectin bloodstream. A recent clinical trial, Prospective Pioglitazone Clinical Trial Macrovascular Events, demonstrated that improved cardiovascular outcomes patients type 2 diabetes mellitus. However, functional role cardioprotection by has not been examined experimentally. Here we investigated effect angiotensin...
Heart failure is a complex syndrome that results from structural or functional impairment of ventricular filling blood ejection. Protein phosphorylation major and essential intracellular mechanism mediates various cellular processes in cardiomyocytes response to extracellular signals. The RHOA-associated protein kinase (ROCK/Rho-kinase), an effector regulated by the small GTPase RHOA, causes pathological proteins, resulting cardiovascular diseases. RHOA also activates N (PKN); however, role...
Heart failure occurs when the heart is unable to effectively pump blood and maintain tissue perfusion. Despite numerous therapeutic advancements over previous decades, prognosis of patients with chronic remains poor, emphasizing need identify additional pathophysiological factors. Here, we show that corticotropin releasing hormone receptor 2 (Crhr2) a G protein-coupled highly expressed in cardiomyocytes continuous infusion Crhr2 agonist, urocortin (Ucn2), reduced left ventricular ejection...
Small animal models of afterload stress have contributed much to our present understanding the progression from hypertension heart failure. High-sensitivity methods for phenotyping cardiac function in vivo, particular setting compensated hypertrophy, may add new information regarding alterations performance that can occur even during earliest stages exposure pressure overload. We developed an echocardiographic analytical method, based on speckle-tracking-based strain analyses, and used this...
Rationale: After cardiac injury, progenitor cells are acutely reduced and replenished in part by regulated self-renewal proliferation, which occurs through symmetric asymmetric cellular division. Understanding the molecular cues controlling cell lineage commitment is critical for harnessing these therapeutic regeneration. We previously have found that surface ATP-binding cassette G-subfamily transporter 2 (Abcg2) influences proliferation of side population (CSP) cells, but unclear...
Objective: To investigate the mechanism responsible for increased cardiac stiffness associated with hypertensive heart failure in Dahl salt-sensitive (DS) rats and effects of treatment combination a calcium channel blocker [azelnidipine (AZE)] angiotensin II type 1 receptor [olmesartan (OLM)]. Methods: DS fed high-salt diet from 7 weeks age were treated (or not) 12 to 19 vasodilator hydralazine, OLM plus AZE, or reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase inhibitor...
The transition from healthy myocardium to hypertensive heart disease is characterized by a series of poorly understood changes in myocardial tissue microstructure. Incremental alterations the orientation and integrity fibers can be assessed using advanced ultrasonic image analysis. We used modified algorithm investigate left ventricular microstructure based on analysis reflection intensity at myocardial-pericardial interface B-mode echocardiographic images. evaluated extent which novel...
The adult mammalian heart has extremely limited cardiac regenerative capacity. Most cardiomyocytes live in a state of permanent cell-cycle arrest and are unable to re-enter the cycle. Cardiomyocytes switch from cell proliferation maturation during neonatal development. Although several signaling pathways involved this transition, molecular mechanisms by which these inputs coordinately regulate cardiomyocyte not fully understood. Retinoic acid (RA) plays pivotal role development,...