A5051804183- Obstructive Sleep Apnea Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Neuroscience of respiration and sleep
- Immunodeficiency and Autoimmune Disorders
- Cleft Lip and Palate Research
- Tracheal and airway disorders
- Acupuncture Treatment Research Studies
- Glaucoma and retinal disorders
- Viral-associated cancers and disorders
- Healthcare and Venom Research
- Retinal Diseases and Treatments
- Vestibular and auditory disorders
- Voice and Speech Disorders
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Respiratory Support and Mechanisms
- Glycosylation and Glycoproteins Research
- Hearing, Cochlea, Tinnitus, Genetics
- Sleep and Wakefulness Research
- Immune Cell Function and Interaction
- Multiple and Secondary Primary Cancers
- Reinforcement Learning in Robotics
- Nuclear Receptors and Signaling
Affiliated Hospital of Nantong University
2013-2025
Nantong University
2013-2025
Beijing Tsinghua Chang Gung Hospital
2018-2025
Tsinghua University
2019-2025
State Grid Corporation of China (China)
2025
Tianjin Medical University
2025
Nanjing Medical University
2008-2024
Shengli Oilfield Central Hospital
2021-2024
Chengdu University of Traditional Chinese Medicine
2021-2024
Huazhong University of Science and Technology
2015-2024
CD5 is a pan-T-cell surface marker and rarely expressed in diffuse large B-cell lymphoma (DLBCL). Large-scale studies of de novo CD5+ DLBCL are lacking Western countries. In this study by the Rituximab-CHOP Consortium, was 5.5% 879 patients from associated with higher frequencies >1 ECOG performance status, bone marrow involvement, central nervous system relapse, activated B-cell-like subtype, Bcl-2 overexpression, STAT3 NF-κB activation, whereas single-stranded DNA-binding protein 2...
PTEN loss has been associated with poorer prognosis in many solid tumors. However, such investigation lymphomas is limited. In this study, cytoplasmic and nuclear expression, gene deletion, mutations were evaluated two independent cohorts of diffuse large B-cell lymphoma (DLBCL). Cytoplasmic expression was found approximately 67% total 747 DLBCL cases, more frequently the activated B-cell–like subtype. Nuclear less frequent at lower levels, which significantly correlated higher mRNA...
To test whether the integration of both anatomical and nonanatomical parameters (ventilatory control, arousal threshold, muscle responsiveness) in a physiology-based model will improve ability to predict outcomes after upper airway surgery for obstructive sleep apnea (OSA).In 31 patients who underwent OSA, loop gain threshold were calculated from preoperative polysomnography (PSG). Three models compared: (1) multiple regression based on an extensive list PSG alone; (2) multivariate using...
Deep brain stimulation (DBS) is an established treatment for patients with Parkinson's disease (PD). Sleep disorders are common complications of PD and affected by subthalamic DBS treatment. To achieve more precise neuromodulation, chronicsleepmonitoringand closed-loop toward sleep–wake cycles could potentially be utilized. Local field potential (LFP) signals that sensed the electrode processed as primary feedback signals. This first study to systematically investigate sleep-stage...
Lymphoplasmacytic lymphoma secreting IgG or IgA (non-IgM LPL) is rarely seen. Systematic studies of the clinical features and treatment outcomes are lacking in these patients. This study evaluated 17 patients with non-IgM LPL. The paraprotein secreted by tumors was (n = 8; 47%) 9; 53%). median serum level 2,475 mg/dl (range 747–5260) for 2580 1900–7100) IgG. IgA-LPL group more likely to present B symptoms, a high beta2-microglobulin extramedullary involvement. Compared Waldenström...
Abstract Objective To investigate machine learning‐based regression models to predict the postoperative apnea‐hypopnea index (AHI) for evaluating outcome of velopharyngeal surgery in adult obstructive sleep apnea (OSA) subjects. Study Design A single‐center, retrospective, cohort study. Setting Sleep medical center. Methods All subjects with OSA who underwent followed 3 6 months were enrolled this Demographic, polysomnographic, and anatomical variables analyzed. Compared traditional stepwise...
Controversy exists as to whether elevated loop gain is a cause or consequence of obstructive sleep apnea (OSA). Upper airway surgery commonly performed in Asian patients with OSA who have failed positive pressure therapy and are thought anatomical predisposition OSA. We hypothesized that high would decrease following surgical treatment due reduced severity.Polysomnography was preoperatively postoperatively assess severity 30 Chinese participants underwent upper surgery. Loop calculated using...
Interleukin (IL)-17A, a proinflammatory cytokine produced by T-helper (Th)17 cells, has been associated with autoimmune diseases. Type 1 diabetes (T1D) is caused either due to mutation of insulin gene or developed as an disease. Studies have shown that IL-17A expression upregulated in the pancreas T1D patients and animal models. However, role importance pathogenesis needs elucidation. Particularly, evidence for direct injury pancreatic β cells through activating IL-17 receptor A (IL-17RA)...
To explore whether the variables resulting from anatomical and physiological examinations can be combined to predict outcomes of velopharyngeal surgery for obstructive sleep apnea (OSA).Prospective design with a retrospective review.A total 119 patients OSA received surgery, including revised uvulopalatopharyngoplasty uvula preservation transpalatal advancement pharyngoplasty. The preoperative these patients, polysomnography (PSG), physical examination, three-dimensional computer tomography...
Background Inflammatory cytokines play an important role in the pathogenesis of heart failure. We have recently found cytokine TWEAK (tumor necrosis factor (TNF)-like weak inducer apoptosis), a member TNF superfamily, to be increased patients with cardiomyopathy and result development failure when overexpressed mice. The molecular mechanisms underlying TWEAK-induced cardiac pathology, however, remain unknown. Methodology Critical Finding Using mouse models elevated circulating levels,...
// Ana Batlle-López 1 , Sonia González de Villambrosía Mazorra Francisco Sefora Malatxeberria Anabel Sáez 2 Carlos Montalban 3 Lydia Sánchez 4 Juan F. Garcia 5 Eva González-Barca 6 Andrés López-Hernández 7 MC Ruiz-Marcellan Manuela Mollejo 8 Grande 9 Kristy L. Richards 10 Eric D. Hsi 11 Alexandar Tzankov 12 Carlo Visco 13 Zijun Y. Xu-Monette 14 Xin Cao Ken H. Young Miguel Ángel Piris Eulogio Conde Santiago Montes-Moreno Departments of Haematology and Pathology, Hospital Marques Valdecilla,...
Ascending thoracic aortic aneurysm (ATAA) is driven by angiotensin II (AngII) and contributes to the development of left ventricular (LV) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments AngII-induced abdominal aneurysms in apolipoprotein E-deficient mice. hypothesized synthesized mediates ATAA.Following demonstration synthesis samples human ATAA associated with different etiologies, we modeled situ expression mice applying exogenous...
The prognostic importance of extramedullary involvement in patients with Waldenström macroglobulinemia (WM) at diagnosis and treatment options for these has not been well evaluated. In this study, we investigated the clinical manifestations, biological features, effect first-line therapy on outcome WM diagnosed (EMWM) vs those only bone marrow (BMWM). We analyzed data 312 EMWM (n = 106) BMWM 206) University Texas MD Anderson Cancer Center from 1994 to 2014. was confirmed by biopsy, positron...
Electroacupuncture (EA) at the Neiguan acupoint (PC6) has shown significant cardioprotective effects. Sympathetic nerves play an important role in maintaining cardiac function after myocardial infarction (MI). Previous studies have found that EA treatment may improve by modulating sympathetic remodeling MI. However, mechanism how affects and improves remains unclear. The aim of this study is to investigate ischemic injury improving promoting macrophage M2 polarization. We established a mouse...
Rationale: After cardiac injury, progenitor cells are acutely reduced and replenished in part by regulated self-renewal proliferation, which occurs through symmetric asymmetric cellular division. Understanding the molecular cues controlling cell lineage commitment is critical for harnessing these therapeutic regeneration. We previously have found that surface ATP-binding cassette G-subfamily transporter 2 (Abcg2) influences proliferation of side population (CSP) cells, but unclear...