A5074244429- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Cutaneous lymphoproliferative disorders research
- CNS Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Sarcoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Monoclonal and Polyclonal Antibodies Research
- NF-κB Signaling Pathways
- Glycosylation and Glycoproteins Research
- Ubiquitin and proteasome pathways
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Acute Lymphoblastic Leukemia research
- Eosinophilic Disorders and Syndromes
- Galectins and Cancer Biology
- Histiocytic Disorders and Treatments
- Protein Degradation and Inhibitors
- MicroRNA in disease regulation
- RNA modifications and cancer
Instituto de Investigación Marqués de Valdecilla
2016-2025
Marqués de Valdecilla University Hospital
2016-2025
Fundación Marques de Valdecilla
2011-2024
Universidad de Cantabria
2011-2024
Centro de Investigación Biomédica en Red de Cáncer
2018-2023
Instituto de Salud Carlos III
2010-2022
Centre for Biomedical Network Research on Rare Diseases
2022
The University of Texas MD Anderson Cancer Center
2013-2018
Paulsson (United States)
2015
Asociación Española Contra el Cáncer
2015
Cutaneous CD4 small/medium-sized pleomorphic T-cell lymphoma (CSTCL) is a cutaneous defined by predominance of small-to-medium-sized T cells, with favorable clinical course. Cases are also characterized the presence rich infiltrate reactive B cells. Recently, it has been reported that follicular helper cells (TFH cells) display distinct gene expression profile, positive for PD-1, CXCL13, and BCL-6. We report first time PD-1 other TFH cell markers in CSTCLs discuss its biologic significance....
The microenvironment influences outcome in follicular lymphoma. Our hypothesis was that several immune cell subsets are important for disease and their individual prognostic importance should be demonstrable the same analysis competition with clinical factors.Seventy lymphoma patients extreme ("poor" "good" cases) were selected a population-based cohort of 197. None 37 good-outcome died from lymphoma, whereas all 33 poor-outcome succumbed <or=5 years. Furthermore, followed long time needed...
Diffuse large B-cell lymphoma can be classified by gene expression profiling into germinal center and activated subtypes with different prognoses after rituximab-CHOP. The importance of previously recognized prognostic markers, such as Bcl-2 protein BCL2 abnormalities, has been questioned in the new therapeutic era. We analyzed expression, MYC abnormalities interphase fluorescence situ hybridization 327 patients de novo disease treated Isolated rearrangements were not predictive outcome our...
Background Plasmablastic lymphoma has recently come to be considered a distinct entity among mature B cell neoplasms, although the limits with diffuse large B-cell (DLBCL) need more accurately defined.Design and Methods Here we show results of an immunohistochemical study 35 cases plasmablastic compared set 111 conventional DLBCLs.Results Our demonstrate that use limited combination markers (PAX5&CD20, PRDM1/BLIMP1 XBP1s) enables identification immunophenotype highly characteristic...
Abstract Purpose: Epstein–Barr virus–positive (EBV+) diffuse large B-cell lymphoma (DLBCL) of the elderly is a variant DLBCL with worse outcome that occurs most often in East-Asian countries and uncommon Western hemisphere. We studied largest cohort EBV+ DLBCL, independent age, treated rituximab combined CHOP (R-CHOP) developed countries. Experimental design: A (n = 732) patients R-CHOP chemotherapy included from multicenter consortium. This study group has been for expression different...
Primary cutaneous γδ T-cell lymphomas (PCGD-TCLs) are considered a subgroup of aggressive cytotoxic (CTCLs). We have taken advantage new, commercially available antibody that recognizes the receptor-γ (TCR-γ) subunit TCR in paraffin-embedded tissue. analyzed series 146 primary received for consultation or second opinion CNIO Pathology Department. Cases were classified according to World Health Organization 2008 classification as mycosis fungoides (MF; n=96), PCGD-TCLs (n=5), pagetoid...
Double-hit B-cell lymphoma is a common designation for group of tumors characterized by concurrent translocations MYC and BCL2, BCL6, or other genes. The prognosis BCL6 not well known. In this study, we assessed rearrangements expression MYC, BCL2 in 898 patients with de novo diffuse large treated standard chemotherapy (cyclophosphamide, doxorubicin, vincristine, prednisone plus rituximab). Neither translocation alone (more frequent activated like lymphoma) nor combination (observed 2.0%...
The nodularity and presence of T-cell rosettes surrounding the neoplastic cells has been described as a defining feature nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). We have explored potential diagnostic value new marker (NAT105) that recognizes antigen PD-1 in series 152 cases diagnosed sclerosis lymphoma, mixed cellularity lymphocyte-rich classic NLPHL, T-cell/histiocyte-rich B-cell (T/HRBCL). All were immunostained with panel antibodies against CD10, bcl-6, CXCL13, CD57,...
Peripheral T-cell lymphomas (PTCLs) in western countries are uncommon tumors with unfavorable prognosis. They may be subclassified as anaplastic large-cell (ALCLs), angioimmunoblastic-T-cell (AITLs), or unspecified peripheral (PTCLs-U). It has recently been demonstrated that AITLs originate from germinal center follicular helper T cells (TFH), whereas the normal counterparts of other PTCLs remain essentially unknown. The aim this study was to establish whether PTCL subgroups also express TFH...
In Brief We have reviewed clinically, morphologically, and immunophenotypically a series of 14 Epstein-Bar virus (EBV)+ cutaneous natural killer cell (NK)/T-cell lymphoma from Peru. Most (11 out 14) these cases fit well into the category Hydroa vacciniforme-like (HVLL), but 3 different clinical presentation, without facial involvement. all cases, skin lesions present in both sun-exposed nonexposed areas exhibited slowly progressive relapsing course, changing edema, to blistering, ulceration,...
Accurate lymphoma diagnosis, prognosis and therapy still require additional markers. We explore the potential relevance of microRNA (miRNA) expression in a large series that included all major B-cell non-Hodgkin (NHL) types. The data generated were also used to identify miRNAs differentially expressed Burkitt (BL) diffuse (DLBCL) samples. A 147 NHL samples 15 controls hybridized on human miRNA one-color platform containing probes for 470 miRNAs. Each type was compared against entire set...
MYD88 L265P is a somatic mutation that has been identified in about 90% of Waldenström macroglobulinemia/lymphoplasmacytic lymphomas (LPLs). It also detected subset marginal zone lymphoma (MZL) cases, but the frequency and clinical histologic features these mutated MZL cases only partially characterized. We have developed customized TaqMan allele-specific polymerase chain reaction for sensitive detection this paraffin-embedded tissue. analyzed samples from 19 patients with LPL, 88 splenic...