A5036114839- Cell Adhesion Molecules Research
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Immunotherapy and Immune Responses
- Wnt/β-catenin signaling in development and cancer
- Monoclonal and Polyclonal Antibodies Research
- Muscle Physiology and Disorders
- Kruppel-like factors research
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- Cell death mechanisms and regulation
- Virus-based gene therapy research
- T-cell and B-cell Immunology
- Ubiquitin and proteasome pathways
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- Poxvirus research and outbreaks
- Protein Degradation and Inhibitors
- interferon and immune responses
- Cancer Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Platelet Disorders and Treatments
- Telomeres, Telomerase, and Senescence
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2015-2025
Instituto de Salud Carlos III
2015-2025
The Francis Crick Institute
2017-2025
Institució Catalana de Recerca i Estudis Avançats
2010-2023
University of Louisville
2011-2023
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas
2013-2023
Target (United States)
2016-2023
James Graham Brown Foundation
2011-2023
Universitat de Barcelona
2021-2023
Centro de Investigación Biomédica en Red
2023
In most carcinomas, invasion of malignant cells into surrounding tissues involves their molecular reprogramming as part an epithelial-to-mesenchymal transition (EMT). Mutation the APC gene in colorectal carcinomas (CRCs) contributes to nuclear translocation oncoprotein β-catenin that upon binding T-cell and lymphoid enhancer (TCF-LEF) factors triggers EMT a proinvasive expression profile. A key inducer is ZEB1 transcription factor whose promotes tumorigenesis metastasis carcinomas. As...
ZEB is an active transcriptional repressor that regulates lymphocyte and muscle differentiation in vertebrates. Its homologue Drosophila ( zfh-1 ) also essential for of somatic cardiac muscle. Here, we demonstrate interact with the corepressor CtBP to repress transcription. , both contain sequence PLDLS same region domain, this binds CtBP-1 -2. In vertebrate species, contains two additional CtBP-like binding sites (variations sequence) bind proteins are required full activity. The three have...
The VLA-4 (CD49d/CD29) integrin is a cell surface receptor involved in the interaction of lymphoid cells with both extracellular matrix (ECM) and endothelial cells. We have investigated expression function fibronectin (FN) receptors on T localized inflammed synovium patients rheumatoid arthritis (RA). A high proportion synovial membrane (SM) fluid (SF) expressed activation antigens AIM (CD69) gp95/85 (Ea2) as well an increased number alpha beta 1 adhesion molecules, compared peripheral blood...
Zeb1-induced immune checkpoints promote M2 macrophages and protect invading lung cancer cells from inflammatory cells.
Abstract Acute inflammation can either resolve through immunosuppression or persist, leading to chronic inflammation. These transitions are driven by distinct molecular and metabolic reprogramming of immune cells. The anti-diabetic drug Metformin inhibits acute mechanisms still not fully understood. Here, we report that the anti-inflammatory reactive-oxygen-species-inhibiting effects depend on expression plasticity factor ZEB1 in macrophages. Using mice lacking Zeb1 their myeloid cells human...
Vaccinia virus, known for its clinical safety has a tropism primary and metastatic tumours as well ovarian tissue. Consequently, oncolytic approaches with recombinant vaccinia viruses have emerged attractive agents against cancer. Unfortunately, monotherapies are yet to live up their potential promise. Given this, there is need identify combination that improve the effectiveness of in cancer treatment. We screened 9,000 compounds drugs enhance ability virus lacking VGF F1 (ΔVF) induce death...
zfh-1 is a zinc finger/homeodomain transcriptional repressor in Drosophila that regulates differentiation of muscle and gonadal cells also expressed the central nervous system (CNS). Binding sites for overlap with those snail, like snail , it recruits corepressor CtBP-1. The protein ZEB-1 appears to be vertebrate homologue several tissues including muscle, CNS, T lymphocytes, during skeletal differentiation. Mutation gene led severe cell phenotype defects but, interestingly, no were evident...
Cell-cell and cell-extracellular matrix interactions are mediated by a wide array of cell surface molecules known as adhesion receptors, including the integrin family that comprises numerous alpha beta heterodimers. A new group, 7 subfamily, has been recently defined. Its two members, 4 H 7, involved in lymphocyte migration to Peyer's patches intestinal mucosa, respectively. We have analyzed expression on B cells from different cellular compartments at activation states. Resting peripheral...
Host innate immune responses to DNA viruses involve members of the nucleotide-binding domain, leucine-rich repeat and pyrin domain containing protein (NLRP) family, which form “inflammasomes” that activate caspase-1, resulting in proteolytic activation cytokines interleukin (IL)-1β IL-18. We hypothesized would target inflammasomes overcome host defense. A Vaccinia virus (VACV) B-cell CLL/lymphoma 2 (Bcl-2) homolog, F1L, was demonstrated bind inhibit NLR family member NLRP1 vitro. Moreover,...
Epithelial cells are dependent upon adhesion to extracellular matrix for survival. We show that loss of μ1 integrin receptor contact with signals the inhibition G1 cyclin-dependent kinase activity. This activity leads accumulation hypophosphorylated (active) form retinoblastoma tumor suppressor protein (Rb). present evidence in epithelial deprived contact, growth suppression signal elicited by Rb opposes stimulatory from serum factors, leading a cell cycle conflict triggers apoptosis....