A5063529902- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Neuroscience and Neuropharmacology Research
- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
- Hippo pathway signaling and YAP/TAZ
- Signaling Pathways in Disease
- Nuclear Receptors and Signaling
- Genetic Neurodegenerative Diseases
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Neuroendocrine regulation and behavior
- Receptor Mechanisms and Signaling
- Cell Adhesion Molecules Research
- Ubiquitin and proteasome pathways
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Pancreatic function and diabetes
- Photoreceptor and optogenetics research
- Protein Tyrosine Phosphatases
- Stress Responses and Cortisol
- Apelin-related biomedical research
- Cellular transport and secretion
- Adipose Tissue and Metabolism
Max Planck Institute for Biological Intelligence
2022-2024
Max Planck Institute of Biochemistry
2022-2024
Max Planck Institute for Intelligent Systems
2023
Max Planck Institute of Neurobiology
2013-2022
Munich Cluster for Systems Neurology
2013-2019
RELX Group (United States)
2016
Max Planck Society
2005-2014
Toxicologie, Pharmacologie et Signalisation Cellulaire
2014
Medizinische Hochschule Hannover
2010-2011
University of Bonn
2009
Insulin receptors (IRs) and insulin signaling proteins are widely distributed throughout the central nervous system (CNS). To study physiological role of in brain, we created mice with a neuron-specific disruption IR gene (NIRKO mice). Inactivation had no impact on brain development or neuronal survival. However, female NIRKO showed increased food intake, both male developed diet-sensitive obesity increases body fat plasma leptin levels, mild resistance, elevated hypertriglyceridemia. also...
Ralf H. Adams, George A. Wilkinson, Cornelia Weiss, Francesca Diella, Nicholas W. Gale, Urban Deutsch, Werner Risau, and Rüdiger Klein European Molecular Biology Laboratory, D-69117 Heidelberg, Germany; Max-Planck-Institute for Physiological Clinical Research, W.G. Kerckhoff Institute, 61231 Bad Nauheim, Regeneron Pharmaceuticals, Inc., Tarrytown, New York 10591 USA
The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of embryonic blood vascular morphogenesis. However, the molecular mechanisms required for transduced cellular signaling in vivo have not been characterized. To address this question, we generated two sets knock-in mice: Δ V mice expressed lacking C-terminal PDZ interaction site, 5F which five conserved residues were replaced by phenylalanine to disrupt phosphotyrosine-dependent events....