A5102873527- Economic and Financial Impacts of Cancer
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Health Systems, Economic Evaluations, Quality of Life
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Patient-Provider Communication in Healthcare
- Childhood Cancer Survivors' Quality of Life
- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Patient Dignity and Privacy
- COVID-19 and healthcare impacts
- Ethics in Clinical Research
- Cancer-related cognitive impairment studies
- Cancer Genomics and Diagnostics
- BRCA gene mutations in cancer
- Telemedicine and Telehealth Implementation
- Advances in Oncology and Radiotherapy
- Health Literacy and Information Accessibility
- Clinical practice guidelines implementation
- Frailty in Older Adults
- Mobile Health and mHealth Applications
- Chronic Lymphocytic Leukemia Research
- Multiple and Secondary Primary Cancers
- HER2/EGFR in Cancer Research
University of Alabama at Birmingham
2016-2025
American Cancer Society
2025
O'Neal Comprehensive Cancer Center
2019-2025
University of North Carolina at Chapel Hill
2023
St. Vincent's Birmingham
2018-2023
Institut Curie
2023
University of Alabama
2015-2022
John Wiley & Sons (United States)
2020
Bayer (United States)
2020
Astellas Pharma (United Kingdom)
2020
The blockbuster chemotherapy drug paclitaxel is widely presumed to cause cell death in tumors as a consequence of mitotic arrest, it does at concentrations routinely used culture. However, we determine here that levels primary breast are well below those required elicit sustained arrest. Instead, cells these lower proceed through mitosis without substantial delay and divide their chromosomes on multipolar spindles, resulting chromosome missegregation death. Consistent with culture data, most...
Abstract Breast cancer is the most commonly diagnosed worldwide and one of leading causes death. The incidence, pathological features, clinical outcomes in breast differ by geographical distribution across racial ethnic populations. Importantly, diversity trials lacking, with both Blacks Hispanics underrepresented. In this forum article, researchers from globe discuss factors contributing to disparities highlight specific implications precision oncology approaches for equitable provision...
Abstract Background In qualitative work, patients report that seemingly short trips to clinic (eg, a supposed 10-minute blood draw) often turn into “all-day affairs.” We sought quantify the time with cancer spend attending ambulatory appointments. Methods conducted retrospective study of scheduled for oncology-related care labs, imaging, procedures, infusions, and clinician visits) at an academic center over 1 week. The primary exposure was service type(s) visit only, labs infusion, etc.)....
Lay navigators in the Patient Care Connect Program support patients with cancer from diagnosis through survivorship to end of life. They empower engage their health care and navigate them increasingly complex system. Navigation programs can improve access care, enhance coordination overcome barriers timely, high-quality care. However, few data exist regarding financial implications implementing a lay navigation program.To examine influence on spending resource use among geriatric within The...
Shortly before I was elected President of ASCO, attended the 65th birthday party a current patient. She had been diagnosed 10 years earlier with metastatic breast cancer and hadn't sure she wanted to move forward further treatment. With encouragement, participate in clinical trial an investigational drug that is now widely used treat cancer. Happily, here we were, celebrating her now-married daughters, their husbands, three beautiful grandchildren, ages 2, 4, 8. Such importance trials...
Despite advances in the care of patients with cancer over last 10 years, remains second leading cause death United States. Many receive aggressive, in-hospital end-of-life at high cost. There are few data on outcomes after unplanned hospitalization metastatic cancer.In 2000 and 2010, were collected admissions, interventions, survival for admitted to an academic inpatient medical oncology service.The survey included 191 admissions 151 unique patients. The 2010 assessed 149 119 Lung, GI,...
BACKGROUND To the authors' knowledge, few studies to date have evaluated effects of survivorship care planning on transition process from specialty cancer self‐management and primary care, patient experience, or health outcomes. The P atient‐ o wned S urvivorship T ransition C are for A ctivated, E mpowe re d survivors (POSTCARE) is a single coaching encounter based Chronic Care Model that uses motivational interviewing techniques engage breast cancer. current study examined POSTCARE...
Abstract Background Adequate social support for older adults is necessary to maintain quality of life and reduce mortality morbidity. However, little known regarding the needs with cancer. The objective current study was examine needs, specifically unmet among Methods Medicare beneficiaries (those aged ≥65 years) cancer were identified from University Alabama at Birmingham Health System Cancer Community Network. Social assessed using a modified version Medical Outcomes Study Support Survey....
Many community cancer clinics closed between 2008 and 2016, with additional closings potentially expected. Limited data exist on the impact of travel time health care costs resource use.This retrospective cohort study (2012 to 2015) evaluated site for Medicare beneficiaries age 65 years or older in southeastern United States. The primary outcome was spending by phase (ie, initial, survivorship, end life). Secondary outcomes included patient cost responsibility use measured hospitalization...
Aims Numerous healthcare decisions are faced by persons with advanced cancer from diagnosis to end-of-life. The family caregiver role in these has focused on being a surrogate decision-maker, however, little is known about the caregiver's supporting upstream patient decision-making. We aimed describe roles of caregivers assisting community-dwelling patients decision-making across settings and contexts. Methods Qualitative study using one-on-one, semi-structured interviews metastatic (n = 18)...
Despite evidence of clinical benefits, widespread implementation remote symptom monitoring has been limited. We describe a process adapting intervention developed in research setting to real-world at two cancer centers.
Symptoms are common in patients receiving systemic treatment for metastatic cancer. Monitoring with electronic patient-reported outcomes (ePROs) detects severe and worsening symptoms early, enabling care teams to intervene prevent downstream complications thereby improving outcomes. The Centers Medicare & Medicaid Services will require outcome (PRO) monitoring the upcoming Enhancing Oncology Model, many practices likely attempt implement PROs patient first time.To assist design...
Importance Patients with stage IV non–small cell lung cancer (NSCLC) experience substantial morbidity and mortality. Contact days (ie, the number of health care contact outside home) measure how much a person’s life is consumed by care, yet little known about patterns for patients NSCLC. Objective To describe trajectories in NSCLC vary receipt cancer-directed treatment routine practice. Design, Setting, Participants A retrospective, population-based decedent cohort study was conducted...
Health care contact days-days spent receiving health outside the home-represent an intuitive, practical, and person-centered measure of time consumed by care.
The Patient Care Connect Program (PCCP) is a lay patient navigation program, implemented by the University of Alabama at Birmingham Health System Cancer Community Network. PCCP’s goal to provide better health and care, as well lower overall expenditures. program focuses on enhancing patients, with emphasis empowerment promoting proactive participation in care. Navigator training emphasizes palliative care principles includes development skills facilitate advance planning conversations. Lay...
Metastatic breast cancer (MBC) is an ideal environment for shared decision-making because of the large number guideline-based treatment options with similar efficacy but different toxicity profiles. This qualitative analysis describes patient and provider factors that influence in MBC.Patients community oncologists completed in-person interviews. Academic medical participated focus groups. Interviews groups were audio-recorded, transcribed, analyzed using NVivo. Using a priori model based on...
Given the high risk of COVID-19 mortality, patients with cancer may be vulnerable to fear COVID-19, adverse psychological outcomes, and health care delays.This longitudinal study surveyed pandemic's impact on (N= 1529) receiving Patient Advocate Foundation services during early later pandemic. Generalized estimating equation repeated measures was conducted assess effect distress. Logistic regression used any delays in accessing (e.g., specialty doctors, laboratory, or diagnostic testing,...
Frequent visits to health care facilities can be time intensive and all-consuming for people with cancer. We measured contact days (days healthcare outside the home) among decedents advanced GI cancer examined sources of days, their associations demographic clinical factors, temporal patterns over course illness.