Francesco Bertoni
A5066518317- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Sarcoma Diagnosis and Treatment
- Cutaneous lymphoproliferative disorders research
- Viral-associated cancers and disorders
- Bone Tumor Diagnosis and Treatments
- Protein Degradation and Inhibitors
- Monoclonal and Polyclonal Antibodies Research
- CAR-T cell therapy research
- PI3K/AKT/mTOR signaling in cancer
- Multiple Myeloma Research and Treatments
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- Ubiquitin and proteasome pathways
- HER2/EGFR in Cancer Research
- Glycosylation and Glycoproteins Research
- CNS Lymphoma Diagnosis and Treatment
- Immune Cell Function and Interaction
- Genetic factors in colorectal cancer
- Acute Lymphoblastic Leukemia research
- Histone Deacetylase Inhibitors Research
- Oral and Maxillofacial Pathology
- Cancer Genomics and Diagnostics
- Cancer-related molecular mechanisms research
- Genomic variations and chromosomal abnormalities
Institute of Oncology Research
2016-2025
Ente Ospedaliero Cantonale
1997-2025
Università della Svizzera italiana
2011-2025
Fred Hutch Cancer Center
2023
International Extranodal Lymphoma Study Group
2022
Ospedale San Giovanni Bellinzona
2007-2020
Institute of Biomedical Science
2020
European Institute of Oncology
2005-2019
GTx (United States)
2019
Istituti di Ricovero e Cura a Carattere Scientifico
2007-2019
The pathogenesis of chronic lymphocytic leukemia (CLL), the most common in adults, is still largely unknown. full spectrum genetic lesions that are present CLL genome, and therefore number identity dysregulated cellular pathways, have not been identified. By combining next-generation sequencing copy analysis, we show here typical coding genome contains <20 clonally represented gene alterations/case, including predominantly nonsilent mutations, fewer aberrations. These analyses led to...
Splenic marginal zone lymphoma (SMZL) is a B cell malignancy of unknown pathogenesis, and thus an orphan targeted therapies. By integrating whole-exome sequencing copy-number analysis, we show that the SMZL exome carries at least 30 nonsilent gene alterations. Mutations in NOTCH2, required for marginal-zone (MZ) development, represent most frequent lesion SMZL, accounting ∼20% cases. All NOTCH2 mutations are predicted to cause impaired degradation protein by eliminating C-terminal PEST...
In cancer cells, the epigenome is often deregulated, and inhibition of bromodomain extra-terminal (BET) family bromodomain-containing proteins a novel epigenetic therapeutic approach. Preliminary results an ongoing phase I trial have reported promising activity tolerability with new BET inhibitor OTX015.We assessed preclinical OTX015 as single agent in combination mature B-cell lymphoma models performed vitro vivo experiments to identify mechanism action genetic features associated...
BackgroundPlatinum-based chemoradiation (CCRT) is the standard treatment for Locally Advanced Head and Neck Squamous-Cell Carcinoma (LAHNSCC). Cetuximab/RT (CET/RT) an alternative option to CCRT. The efficacy of induction chemotherapy (IC) followed by compared alone has not been demonstrated in randomized clinical trials. goals this phase II-III trial were assess: (i) overall survival (OS) IC versus no-induction (no-IC) (ii) Grade 3–4 in-field mucosal toxicity CCRT CET/RT. present paper...
Coastal countries have traditionally relied on the existing marine resources (e.g., fishing, food, transport, recreation, and tourism) as well tried to support new economic endeavors (ocean energy, desalination for water supply, seabed mining). Modern societies lifestyle resulted in an increased demand dietary diversity, better health well-being, biomedicines, natural cosmeceuticals, environmental conservation, sustainable energy sources. These societal needs stimulated interest of...
Purpose Preliminary results using rituximab in extranodal marginal zone (MALT) non-Hodgkin's lymphoma (NHL) patients seem to indicate a relevant clinical activity. Aim of the present study is investigate efficacy conventional weekly treatment gastric MALT NHL resistant/refractory or not suitable for eradication treatment, and evaluate relevance t(11; 18)(q21; q21) translocation its possible role as predictive criteria response. Patients Methods Twenty-seven presenting with at any stage,...
PURPOSE This study was performed to assess the prognostic value of proposed histopathologic method evaluate response primary tumor preoperative chemotherapy in Ewing's sarcoma. PATIENTS AND METHODS The evaluated from specimens 118 sarcoma patients, who were preoperatively treated by alone. Responses graded I III (macroscopic viable tumor, microscopic and no cells, respectively). Follow-up data available for all with a mean follow-up duration 86 months (range, 30 158). RESULTS A statistically...
Several lines of evidence suggest a link between chronic gastritis due to Helicobacter pylori and mucosa-associated lymphoid-tissue (MALT) lymphoma the stomach.1,2 A close epidemiologic association has been reported.3–5 The microorganism can be found in gastric mucosa nearly all cases, regression low-grade MALT demonstrated after eradication H. pylori. 6,7 suggested progression from pylori–associated overt lymphoma8 not formally demonstrated, although if it exists, such mechanism may have...