A5022929974- Lymphoma Diagnosis and Treatment
- T-cell and Retrovirus Studies
- Chronic Lymphocytic Leukemia Research
- Cancer-related gene regulation
- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- NF-κB Signaling Pathways
- Genomic variations and chromosomal abnormalities
- Ubiquitin and proteasome pathways
- Viral-associated cancers and disorders
- RNA Research and Splicing
- Monoclonal and Polyclonal Antibodies Research
- Genetics and Neurodevelopmental Disorders
- Galectins and Cancer Biology
- Immunodeficiency and Autoimmune Disorders
- CRISPR and Genetic Engineering
- Chronic Myeloid Leukemia Treatments
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Acute Lymphoblastic Leukemia research
City Of Hope National Medical Center
2015-2024
City of Hope
2015
University of Nebraska Medical Center
2005-2014
Guangdong General Hospital
2014
Guangdong Academy of Medical Sciences
2014
Air Force Medical University
2014
Shandong University
2014
Tianjin Medical University Cancer Institute and Hospital
2013
Sichuan University
2013
Nebraska Medical Center
2004-2011
Like other cell-surface receptors with intrinsic or associated protein-tyrosine kinase activity, the T-cell receptor complex undergoes a number of modifications, including tyrosine phosphorylation steps, after ligand binding but before transmitting signal. The requirement for these modifications introduces temporal lag between and signaling. A model is proposed in which this feature greatly enhances receptor's ability to discriminate foreign antigen self-antigens only moderately lower...
Lymphomas arising from NK or γδ-T cells are very aggressive diseases and little is known regarding their pathogenesis. Here we report frequent activating mutations of STAT3 STAT5B in NK/T-cell lymphomas (n=51), γδ-T-cell (n=43) cell lines (n=9) through next generation and/or Sanger sequencing. N642H particularly all forms lymphomas. associated with increased phosphorylated protein a growth advantage to transduced normal cells. Growth-promoting activity the mutants can be partially inhibited...
Chromosomal translocations involving chromosome 3, band q27, are among the most common rearrangements in B-cell non-Hodgkin lymphoma. From a bacteriophage lambda library prepared from lymphoma characterized by t(3;14)(q27;q32), genomic clones were isolated using probe immunoglobulin heavy chain locus (IGH) joining region. In addition to containing an apparently normal IGH rearrangement, others found contain one of translocation breakpoint junctions. Normal 3 sequences and reciprocal junction...
The inducible pleiotropic transcription factor NF-kappa B is composed of two subunits, p50 and p65. subunit encoded on the N-terminal half a 105-kDa open reading frame contains rel-like domain. To date, no function has been described for C-terminal portion. We show here that p105, when expressed as separate molecule, binds to can rapidly disrupt protein-DNA complexes or native B. Deletion analysis this precursor-derived inhibitor activity indicated domain containing ankyrin-like repeats...
Ten patients with strongly Ki-1(CD30)-positive non-Hodgkin's lymphoma (NHL) were identified at our institution during the past 5 years. Based on morphology, lymphomas of five these classified as anaplastic large-cell (ALCL); four lacked morphologic features ALCL (non-ALCL); and one patient was unclassifiable. Significant clinical cytogenetic differences observed between those non-ALCL. The tended to be young time diagnosis. They presented peripheral lymphadenopathy, two had skin involvement....
The aberrant expression of microRNA-155 (miR-155), which has emerged as having a significant impact on the biological characteristics lymphocytes, plays important roles in B-cell malignancies, such diffuse large lymphoma (DLBCL). DLBCL is most common non–Hodgkin's adult population, accounting for approximately 40% newly diagnosed cases globally. To determine specific function miR-155, quantitative proteomics approach was applied to examine inhibitory effects miR-155 protein synthesis cells....
We previously reported that constitutive STAT3 activation is a prominent feature of the activated B-cell subtype diffuse large lymphomas (ABC-DLBCL). In this study, we investigated whether can risk stratify patients with DLBCL.By an immunohistochemical method, phosphotyrosine (PY-STAT3) expression from 185 DLBCL treated R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone). Cell line-based siRNA experiments were also performed to generate 11-gene, PY-STAT3...
Natural killer cell lymphoma (NKCL) constitutes a rare and aggressive form of non-Hodgkin lymphoma, there is little insight into its pathogenesis. Here we show that PRDM1 tumor suppressor gene in NKCLs inactivated by combination monoallelic deletion promoter CpG island hypermethylation. We observed loci 8 18 (44%) NKCL cases. The other allele showed significant methylation 12 17 (71%) In support role as gene, the reconstitution PRDM1-null NK lines led to G2/M cycle arrest, increased...
To identify tumor suppressor genes epigenetically silenced by promoter hypermethylation in extranodal natural killer cell lymphoma (NKCL).Promoter methylation was analyzed with global and locus-specific assays NKCL cases NK lines. Gene expression profiles were used to for which aberrant associated transcriptional silencing. Selected DNA methylations validated RRBS, pyrosequencing, or q-MSP. Decitabine treatment performed evaluate reactivation of methylated genes. The effect evaluated...
The SKW-3 cell line, which was established from the malignant cells of a patient with T-cell chronic lymphocytic leukemia, is characterized by translocation involving chromosome 8 (band q24) and 14 q11) [t(8;14)(q24;q11)]. To determine position gene encoding alpha chain receptor human protooncogene myc (c-myc) in relation to breakpoint junctions evaluate their possible role pathogenesis neoplasia, we applied techniques situ chromosomal hybridization Southern blot analysis cells. Our results...
Our laboratory has reported that t(14;19)(q32; q13.1) is a recurring translocation in the neoplastic cells of patients with chronic lymphocytic leukemia. In present study, we have analyzed leukemic from one such patient probes immunoglobulin heavy-chain locus, which on band q32 chromosome 14. Using probe for alpha constant-region gene segments, detected rearranged by Southern blot analysis. This was cloned and mapped. A subclone free repetitive sequences shown to be 19 analysis human-mouse...
Abstract Six patients with an aggressive leukemia/lymphoma disorder had a t(14;18) as well either t(8;14) (three patients) or t(8;22) patients). Leukemia cells from all three the mature B cell phenotype (Smlg + and TdT − ), whereas two of pre‐B were Smlg . None prior history follicular lymphoma, lymphoma. The clinical, cytogenetic, morphologic characteristics these six along eight previously reported cases both t(14;18), t(8;14), t(2;8) are discussed.