Sandeep S. Davé
A5088101785- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Viral-associated cancers and disorders
- Ubiquitin and proteasome pathways
- Immune Cell Function and Interaction
- T-cell and Retrovirus Studies
- Cancer-related molecular mechanisms research
- HER2/EGFR in Cancer Research
- Monoclonal and Polyclonal Antibodies Research
- Metabolism and Genetic Disorders
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- CAR-T cell therapy research
- Erythrocyte Function and Pathophysiology
- Cancer-related gene regulation
- Immunodeficiency and Autoimmune Disorders
- Lipoproteins and Cardiovascular Health
- interferon and immune responses
- Genetic factors in colorectal cancer
- Parathyroid Disorders and Treatments
- Bone health and treatments
- Cancer, Lipids, and Metabolism
- Hemoglobinopathies and Related Disorders
- Biomedical Research and Pathophysiology
- Liver Disease Diagnosis and Treatment
Texas A&M University
2025
Duke University
2015-2024
Duke Medical Center
2013-2024
University College London
2024
Monroe Carell Jr. Children's Hospital
2024
Duke University Hospital
2013-2023
Children's Mercy Hospital
2023
The University of Texas Southwestern Medical Center
2021
Duke Cancer Institute
2013-2020
Cancer Genetics (United States)
2018
The addition of rituximab to combination chemotherapy with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP), or R-CHOP, has significantly improved the survival patients diffuse large-B-cell lymphoma. Whether gene-expression signatures correlate after treatment lymphoma is unclear.We profiled gene expression in pretreatment biopsy specimens from 181 who received CHOP 233 this disease R-CHOP. A multivariate gene-expression-based survival-predictor model derived a training...
Patients with follicular lymphoma may survive for periods of less than 1 year to more 20 years after diagnosis. We used gene-expression profiles tumor-biopsy specimens obtained at diagnosis develop a molecular predictor the length survival.Gene-expression profiling was performed on 191 biopsy from patients untreated lymphoma. Supervised methods were discover expression patterns associated survival in training set 95 specimens. A constructed these genes and validated an independent test 96...
Ibrutinib is an irreversible inhibitor of Bruton's tyrosine kinase (BTK) and effective in chronic lymphocytic leukemia (CLL). Resistance to inhibitors resistance associated with BTK inhibition have not been characterized. Although only a small proportion patients had relapse during ibrutinib therapy, understanding mechanisms important. We evaluated relapsed disease identify mutations that may mediate resistance.
Gene-expression profiling has been used to define 3 molecular subtypes of diffuse large B-cell lymphoma (DLBCL), termed germinal center B-cell-like (GCB) DLBCL, activated (ABC) and primary mediastinal (PMBL). To investigate whether these DLBCL arise by distinct pathogenetic mechanisms, we analyzed 203 biopsy samples high-resolution, genome-wide copy number analysis coupled with gene-expression profiling. Of 272 recurrent chromosomal aberrations that were associated alterations, 30...
The distinction between Burkitt's lymphoma and diffuse large-B-cell is crucial because these two types of require different treatments. We examined whether gene-expression profiling could reliably distinguish from lymphoma.Tumor-biopsy specimens 303 patients with aggressive lymphomas were profiled for gene expression also classified according to morphology, immunohistochemistry, detection the t(8;14) c-myc translocation.A classifier based on correctly identified all 25 pathologically...
Diffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma. In least curable (ABC) subtype DLBCL, survival malignant cells dependent on constitutive activation nuclear factor-kappaB (NF-kappaB) signaling pathway. normal cells, antigen receptor-induced NF-kappaB requires CARD11, a cytoplasmic scaffolding protein. To determine whether CARD11 contributes to tumorigenesis, we sequenced gene in human DLBCL tumors. We detected missense mutations 7 73 ABC biopsies...
Diffuse large B-cell lymphoma (DLBCL) is the most common form of in adults. The disease exhibits a striking heterogeneity gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome exome sequencing, we characterized diversity DLBCL. In all, sequenced 73 DLBCL primary tumors (34 with matched normal DNA). Separately, exomes 21 cell lines. We identified 322 cancer genes that were recurrently mutated DLBCLs. recurrent mutations...
Background Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form have not been well defined. Overexpression the transcription factor SOX11 has observed in conventional lymphoma. aim study was determine whether gene expressed cyclin its detection may be useful identify these tumors.Design Methods microarray database 238 mature neoplasms re-examined. protein expression...
Abstract Hepatosplenic T-cell lymphoma (HSTL) is a rare and lethal lymphoma; the genetic drivers of this disease are unknown. Through whole-exome sequencing 68 HSTLs, we define recurrently mutated driver genes copy-number alterations in disease. Chromatin-modifying genes, including SETD2, INO80, ARID1B, were commonly HSTL, affecting 62% cases. HSTLs manifest frequent mutations STAT5B (31%), STAT3 (9%), PIK3CD for which there currently exist potential targeted therapies. In addition, noted...
Epstein-Barr virus (EBV), an oncogenic herpesvirus that causes human malignancies, infects and immortalizes primary B cells in vitro into indefinitely proliferating lymphoblastoid cell lines, which represent a model for EBV-induced tumorigenesis. The immortalization efficiency is very low, suggesting innate tumor suppressor mechanism operative. We identify the DNA damage response (DDR) as major component of underlying mechanism. DDR activation was not due to lytic viral replication, nor did...
To elucidate the mechanisms underlying chromosomal translocations in diffuse large B cell lymphoma (DLBCL), we investigated nature and extent of immunoglobulin class switch recombination (CSR) these tumors. We used Southern blotting to detect legitimate illegitimate CSR events tumor samples activated cell–like (ABC), germinal center (GCB), primary mediastinal (PMBL) subgroups DLBCL. The frequency was lower ABC DLBCL than GCB PMBL. In contrast, had a higher internal deletions within μ (Sμ)...